hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04031

Confidence: Medium

Genename	Protein Name	Links
MPC1	Mitochondrial pyruvate carrier 1 (Brain protein 44-like protein)	UniProt NCBI
FAM174A	Membrane protein FAM174A (Hepatitis C virus NS5A-transactivated protein 6) (HCV NS5A-transactivated protein 6) (Transmembrane protein 157)	UniProt NCBI
GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15)	UniProt NCBI
HSD17B6	17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.239) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 6)	UniProt NCBI
NRM	Nurim (Nuclear envelope membrane protein) (Nuclear rim protein)	UniProt NCBI
ATP2B4	Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)	UniProt NCBI
DGAT1	Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase)	UniProt NCBI
ATP2B2	Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2)	UniProt NCBI
SLC49A4	Solute carrier family 49 member 4 (Disrupted in renal cancer protein 2) (Disrupted in renal carcinoma protein 2)	UniProt NCBI
ATP2B1	Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1)	UniProt NCBI
MPC2	Mitochondrial pyruvate carrier 2 (Brain protein 44)	UniProt NCBI
LEMD2	LEM domain-containing protein 2 (hLEM2)	UniProt NCBI
MAOB	Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B)	UniProt NCBI
TMEM168	Transmembrane protein 168	UniProt NCBI
SFT2D3	Vesicle transport protein SFT2C (SFT2 domain-containing protein 3)	UniProt NCBI
APOD	Apolipoprotein D (Apo-D) (ApoD)	UniProt NCBI
ATP2B3	Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-418359	1.10853396923e-07	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Reduction of cytosolic Ca++ levels
REAC:R-HSA-418360	4.20800140747e-06	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Platelet calcium homeostasis
KEGG:04978	1.02342681356e-05	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Mineral absorption
GO:0005388	1.2141890105e-05	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	calcium transmembrane transporter activity, phosphorylative mechanism
KEGG:04961	1.44030781751e-05	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Endocrine and other factor-regulated calcium reabsorption
REAC:R-HSA-5578775	4.88746058957e-05	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Ion homeostasis
REAC:R-HSA-936837	5.84270092927e-05	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Ion transport by P-type ATPases
GO:1905056	6.17566316957e-05	0.176470588235	ATP2B2 ATP2B3 ATP2B1	calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
KEGG:04970	7.07622782665e-05	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Salivary secretion
KEGG:04972	0.00010181807124	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Pancreatic secretion
KEGG:04925	0.000142009977892	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Aldosterone synthesis and secretion
REAC:R-HSA-418346	0.000434083104937	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Platelet homeostasis
KEGG:04261	0.000651475533617	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Adrenergic signaling in cardiomyocytes
KEGG:04022	0.000925787571071	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	cGMP-PKG signaling pathway
KEGG:04020	0.00148547678124	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Calcium signaling pathway
GO:0015662	0.00156251956271	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	ion transmembrane transporter activity, phosphorylative mechanism
REAC:R-HSA-5576891	0.00174494816792	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Cardiac conduction
KEGG:04024	0.00193106489876	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	cAMP signaling pathway
REAC:R-HSA-983712	0.00795770465707	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Ion channel transport
REAC:R-HSA-397014	0.0105661647535	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	Muscle contraction
GO:0030165	0.0164292507258	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	PDZ domain binding
GO:0098982	0.0175382456253	0.176470588235	ATP2B2 ATP2B3 ATP2B1	GABA-ergic synapse
GO:0019829	0.0177311814736	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	ATPase-coupled cation transmembrane transporter activity
GO:1903779	0.0221005099466	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	regulation of cardiac conduction
REAC:R-HSA-75109	0.0233692097873	0.117647058824	DGAT1 GPAM	Triglyceride biosynthesis
WP:WP325	0.0234942020722	0.117647058824	DGAT1 GPAM	Triacylglyceride Synthesis
GO:0042625	0.0237209816777	0.235294117647	ATP2B2 ATP2B3 ATP2B4 ATP2B1	ATPase-coupled ion transmembrane transporter activity
WP:WP536	0.0245305403522	0.176470588235	ATP2B2 ATP2B3 ATP2B1	Calcium Regulation in the Cardiac Cell

Edges

Protein 1	Protein 2	Score	Precision	Evidence
SFT2D3	ATP2B2	0.573	0.655	bioplex (ATP2B2) bioplex_WMM
ATP2B3	HSD17B6	0.379	0.549	bioplex (HSD17B6) bioplex_WMM
ATP2B2	MPC1	0.353	0.539	bioplex (ATP2B2) bioplex_WMM
HSD17B6	ATP2B2	0.274	0.487	bioplex (ATP2B2,HSD17B6) bioplex_WMM
ATP2B3	ATP2B2	0.273	0.486	bioplex (ATP2B2) bioplex_WMM
ATP2B2	MAOB	0.222	0.466	bioplex (ATP2B2) bioplex_WMM
ATP2B4	HSD17B6	0.143	0.405	bioplex (HSD17B6) bioplex_WMM
ATP2B2	GPAM	0.133	0.405	bioplex (ATP2B2) bioplex_WMM
NRM	ATP2B2	0.084	0.347	bioplex (ATP2B2) bioplex_WMM
ATP2B1	HSD17B6	0.055	0.309	bioplex (HSD17B6) bioplex_WMM
TMEM168	ATP2B2	0.053	0.298	bioplex (ATP2B2) bioplex_WMM
FAM174A	TMEM168	0.047	0.293	bioplex (FAM174A) bioplex_WMM
ATP2B2	DGAT1	0.043	0.269	bioplex (ATP2B2) bioplex_WMM
ATP2B4	ATP2B2	0.035	0.263	bioplex (ATP2B2) bioplex_WMM
ATP2B2	MPC2	0.035	0.266	bioplex (ATP2B2) bioplex_WMM
ATP2B2	APOD	0.028	0.23	bioplex (ATP2B2) bioplex_WMM
ATP2B2	LEMD2	0.022	0.206	bioplex (ATP2B2) bioplex_WMM
ATP2B2	SLC49A4	0.021	0.191	bioplex (ATP2B2) bioplex_WMM
ATP2B1	ATP2B2	0.017	0.171	bioplex (ATP2B2) bioplex_WMM
ATP2B1	ATP2B3	0.01	0.129	bioplex_WMM gupta_WMM WMM_only
ATP2B4	ATP2B1	0.009	0.112	bioplex_WMM youn_WMM gupta_WMM WMM_only
HSD17B6	MPC1	0.008	0.091	bioplex_WMM WMM_only
SFT2D3	MPC1	0.008	0.091	bioplex_WMM WMM_only
SLC49A4	MPC1	0.008	0.091	bioplex_WMM WMM_only
MAOB	MPC1	0.008	0.091	bioplex_WMM WMM_only
TMEM168	MPC1	0.008	0.087	bioplex_WMM WMM_only
NRM	MPC1	0.008	0.087	bioplex_WMM WMM_only
SFT2D3	HSD17B6	0.008	0.085	bioplex_WMM WMM_only
SFT2D3	MAOB	0.008	0.085	bioplex_WMM WMM_only
SFT2D3	SLC49A4	0.008	0.085	bioplex_WMM WMM_only
HSD17B6	MAOB	0.008	0.085	bioplex_WMM WMM_only
HSD17B6	SLC49A4	0.008	0.085	bioplex_WMM WMM_only
MAOB	SLC49A4	0.008	0.085	bioplex_WMM WMM_only
GPAM	MPC1	0.008	0.085	bioplex_WMM WMM_only
FAM174A	MPC1	0.008	0.082	bioplex_WMM WMM_only
TMEM168	SLC49A4	0.008	0.067	bioplex_WMM WMM_only
NRM	SLC49A4	0.008	0.067	bioplex_WMM WMM_only
TMEM168	MAOB	0.008	0.067	bioplex_WMM WMM_only
HSD17B6	TMEM168	0.008	0.067	bioplex_WMM WMM_only
SFT2D3	NRM	0.008	0.067	bioplex_WMM WMM_only
SFT2D3	TMEM168	0.008	0.067	bioplex_WMM WMM_only
NRM	HSD17B6	0.008	0.067	bioplex_WMM WMM_only
NRM	MAOB	0.008	0.067	bioplex_WMM WMM_only
LEMD2	SLC49A4	0.008	0.067	bioplex_WMM WMM_only
MAOB	GPAM	0.008	0.06	bioplex_WMM WMM_only
GPAM	SLC49A4	0.008	0.06	bioplex_WMM WMM_only
SFT2D3	GPAM	0.008	0.06	bioplex_WMM WMM_only
HSD17B6	GPAM	0.008	0.06	bioplex_WMM WMM_only
DGAT1	MPC1	0.008	0.06	bioplex_WMM WMM_only
NRM	TMEM168	0.008	0.06	bioplex_WMM WMM_only
HSD17B6	FAM174A	0.008	0.046	bioplex_WMM WMM_only
FAM174A	MAOB	0.008	0.046	bioplex_WMM WMM_only
FAM174A	SLC49A4	0.008	0.046	bioplex_WMM WMM_only
SFT2D3	FAM174A	0.008	0.046	bioplex_WMM WMM_only
TMEM168	GPAM	0.008	0.04	bioplex_WMM WMM_only
NRM	GPAM	0.008	0.04	bioplex_WMM WMM_only
ATP2B4	ATP2B3	0.008	0.032	bioplex_WMM WMM_only
ATP2B4	TMEM168	0.008	0.033	bioplex_WMM WMM_only
NRM	FAM174A	0.008	0.028	bioplex_WMM WMM_only
DGAT1	SLC49A4	0.008	0.026	bioplex_WMM WMM_only
MAOB	DGAT1	0.008	0.026	bioplex_WMM WMM_only
HSD17B6	DGAT1	0.008	0.026	bioplex_WMM WMM_only
SFT2D3	DGAT1	0.008	0.026	bioplex_WMM WMM_only
SFT2D3	ATP2B4	0.008	0.025	bioplex_WMM gupta_WMM WMM_only
FAM174A	GPAM	0.008	0.028	bioplex_WMM WMM_only
ATP2B3	DGAT1	0.008	0.013	bioplex_WMM WMM_only
ATP2B3	MPC1	0.008	0.024	bioplex_WMM WMM_only
NRM	DGAT1	0.008	0.011	bioplex_WMM WMM_only
TMEM168	DGAT1	0.008	0.011	bioplex_WMM WMM_only
ATP2B4	MPC1	0.007	0.005	bioplex_WMM WMM_only
MPC2	MPC1	0.007	0.007	bioplex_WMM WMM_only
GPAM	DGAT1	0.007	0.004	bioplex_WMM WMM_only
LEMD2	MPC1	0.007	0.012	bioplex_WMM WMM_only
FAM174A	ATP2B2	0.007	0.003	bioplex (ATP2B2,FAM174A) bioplex_WMM
FAM174A	DGAT1	0.007	0.007	bioplex_WMM WMM_only
SFT2D3	MPC2	0.007	0.009	bioplex_WMM gupta_WMM WMM_only
LEMD2	GPAM	0.007	0.012	bioplex_WMM WMM_only
APOD	MPC1	0.007	0.011	bioplex_WMM WMM_only
ATP2B3	MAOB	0.007	0.009	bioplex_WMM WMM_only
ATP2B3	SLC49A4	0.007	0.009	bioplex_WMM WMM_only
SFT2D3	ATP2B3	0.007	0.009	bioplex_WMM WMM_only
ATP2B4	DGAT1	0.007	0.009	bioplex_WMM WMM_only
ATP2B4	SLC49A4	0.007	0.005	bioplex_WMM WMM_only
ATP2B4	MAOB	0.007	0.005	bioplex_WMM WMM_only
ATP2B1	MPC1	0.007	0.005	bioplex_WMM WMM_only
HSD17B6	MPC2	0.007	0.008	bioplex_WMM WMM_only
SLC49A4	MPC2	0.007	0.008	bioplex_WMM WMM_only
MAOB	MPC2	0.007	0.008	bioplex_WMM WMM_only
ATP2B3	TMEM168	0.007	0.006	bioplex_WMM WMM_only
NRM	ATP2B3	0.007	0.006	bioplex_WMM WMM_only
SFT2D3	LEMD2	0.007	0.01	bioplex_WMM WMM_only
HSD17B6	LEMD2	0.007	0.01	bioplex_WMM WMM_only
MAOB	LEMD2	0.007	0.01	bioplex_WMM WMM_only
ATP2B1	TMEM168	0.007	0.004	bioplex_WMM WMM_only
NRM	ATP2B4	0.007	0.006	bioplex_WMM WMM_only
SFT2D3	APOD	0.007	0.005	bioplex_WMM WMM_only
MAOB	APOD	0.007	0.005	bioplex_WMM WMM_only
HSD17B6	APOD	0.007	0.005	bioplex_WMM WMM_only
APOD	SLC49A4	0.007	0.005	bioplex_WMM WMM_only
ATP2B3	GPAM	0.007	0.005	bioplex_WMM WMM_only
TMEM168	MPC2	0.007	0.001	bioplex_WMM WMM_only
NRM	MPC2	0.007	0.001	bioplex_WMM WMM_only
SFT2D3	ATP2B1	0.007	0.002	bioplex_WMM gupta_WMM WMM_only
TMEM168	LEMD2	0.007	0.005	bioplex_WMM WMM_only
NRM	LEMD2	0.007	0.005	bioplex_WMM WMM_only
ATP2B3	FAM174A	0.007	0.001	bioplex_WMM WMM_only
ATP2B4	GPAM	0.007	0.0	bioplex_WMM WMM_only
ATP2B1	MAOB	0.007	0.0	bioplex_WMM WMM_only
ATP2B1	SLC49A4	0.007	0.0	bioplex_WMM WMM_only
GPAM	MPC2	0.007	0.002	bioplex_WMM WMM_only
TMEM168	APOD	0.007	0.002	bioplex_WMM WMM_only
NRM	APOD	0.007	0.002	bioplex_WMM WMM_only
FAM174A	MPC2	0.007	0.001	bioplex_WMM WMM_only
FAM174A	LEMD2	0.007	0.006	bioplex_WMM WMM_only
GPAM	APOD	0.007	0.003	bioplex_WMM WMM_only
NRM	ATP2B1	0.007	0.002	bioplex_WMM WMM_only
ATP2B1	DGAT1	0.007	0.002	bioplex_WMM gupta_WMM WMM_only
FAM174A	APOD	0.007	0.003	bioplex_WMM WMM_only
LEMD2	DGAT1	0.007	0.003	bioplex_WMM WMM_only
ATP2B1	GPAM	0.007	0.005	bioplex_WMM WMM_only
DGAT1	MPC2	0.007	0.004	bioplex_WMM WMM_only
APOD	DGAT1	0.007	0.004	bioplex_WMM WMM_only
ATP2B4	FAM174A	0.007	0.003	bioplex (FAM174A) bioplex_WMM
ATP2B3	MPC2	0.006	0.005	bioplex_WMM WMM_only
ATP2B4	APOD	0.006	0.006	bioplex_WMM WMM_only
APOD	MPC2	0.006	0.004	bioplex_WMM WMM_only
LEMD2	APOD	0.006	0.005	bioplex_WMM WMM_only
ATP2B4	MPC2	0.006	0.004	bioplex_WMM gupta_WMM WMM_only
ATP2B3	APOD	0.006	0.004	bioplex_WMM WMM_only boldt_WMM
ATP2B1	APOD	0.006	0.006	bioplex_WMM WMM_only
ATP2B3	LEMD2	0.006	0.01	bioplex_WMM WMM_only
LEMD2	MPC2	0.006	0.002	bioplex_WMM WMM_only
ATP2B1	LEMD2	0.006	0.008	bioplex_WMM WMM_only
ATP2B4	LEMD2	0.006	0.006	bioplex_WMM WMM_only
ATP2B1	MPC2	0.005	0.011	bioplex_WMM gupta_WMM WMM_only
ATP2B1	FAM174A	0.005	0.003	bioplex (FAM174A) bioplex_WMM

Images

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Complex HuMAP2_04031 has an average edge precision of 0.075 which is ranked 6968 out of all 6965 complexes.

Related Complexes

Genename	Complexes
MPC1	HuMAP2_04031
FAM174A	HuMAP2_02479 HuMAP2_03515 HuMAP2_04031
GPAM	HuMAP2_04031 HuMAP2_05816 HuMAP2_05846 HuMAP2_06645
HSD17B6	HuMAP2_02462 HuMAP2_04031 HuMAP2_04198
NRM	HuMAP2_00908 HuMAP2_01137 HuMAP2_03983 HuMAP2_04031
ATP2B4	HuMAP2_02462 HuMAP2_04031 HuMAP2_04174
DGAT1	HuMAP2_04031
ATP2B2	HuMAP2_02574 HuMAP2_04031
SLC49A4	HuMAP2_04031 HuMAP2_04291
ATP2B1	HuMAP2_02462 HuMAP2_04031 HuMAP2_04198
MPC2	HuMAP2_04031
LEMD2	HuMAP2_03614 HuMAP2_04031
MAOB	HuMAP2_03264 HuMAP2_04031 HuMAP2_06628
TMEM168	HuMAP2_02479 HuMAP2_03515 HuMAP2_04031
SFT2D3	HuMAP2_00524 HuMAP2_00658 HuMAP2_02574 HuMAP2_04031 HuMAP2_04675
APOD	HuMAP2_04031 HuMAP2_04576
ATP2B3	HuMAP2_02462 HuMAP2_04031 HuMAP2_04198

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04031