hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04038
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KRT1 | Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1) | UniProt NCBI |
| KRT77 | Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39) | UniProt NCBI |
| DSP | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | UniProt NCBI |
| KRT5 | Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6809371 | 3.27597019928e-07 | 1.0 | KRT1 KRT77 DSP KRT5 | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 9.67478990718e-07 | 1.0 | KRT1 KRT77 DSP KRT5 | Keratinization |
| HP:0000972 | 1.11400508422e-05 | 0.75 | KRT1 DSP KRT5 | Palmoplantar hyperkeratosis |
| HP:0010765 | 1.66305025548e-05 | 0.75 | KRT1 DSP KRT5 | Palmar hyperkeratosis |
| HP:0007556 | 2.78482704803e-05 | 0.75 | KRT1 DSP KRT5 | Plantar hyperkeratosis |
| GO:0070268 | 7.12285743241e-05 | 1.0 | KRT1 KRT77 DSP KRT5 | cornification |
| HP:0007475 | 0.000136359131835 | 0.5 | KRT1 DSP | Congenital bullous ichthyosiform erythroderma |
| HP:0100872 | 0.00015941280611 | 0.75 | KRT1 DSP KRT5 | Abnormality of the plantar skin of foot |
| HP:0008066 | 0.000173880942073 | 0.75 | KRT1 DSP KRT5 | Abnormal blistering of the skin |
| GO:0031424 | 0.000228860884329 | 1.0 | KRT1 KRT77 DSP KRT5 | keratinization |
| HP:0010783 | 0.000434130330519 | 0.75 | KRT1 DSP KRT5 | Erythema |
| HP:0008404 | 0.000434130330519 | 0.75 | KRT1 DSP KRT5 | Nail dystrophy |
| GO:0030216 | 0.000800055508379 | 1.0 | KRT1 KRT77 DSP KRT5 | keratinocyte differentiation |
| HP:0000982 | 0.00113630295633 | 0.75 | KRT1 DSP KRT5 | Palmoplantar keratoderma |
| GO:0009913 | 0.0014249330287 | 1.0 | KRT1 KRT77 DSP KRT5 | epidermal cell differentiation |
| HP:0200097 | 0.00149887618857 | 0.5 | DSP KRT5 | Oral mucosal blisters |
| GO:0043588 | 0.00195799214531 | 1.0 | KRT1 KRT77 DSP KRT5 | skin development |
| REAC:R-HSA-1266738 | 0.00270117638515 | 1.0 | KRT1 KRT77 DSP KRT5 | Developmental Biology |
| GO:0008544 | 0.00312639352664 | 1.0 | KRT1 KRT77 DSP KRT5 | epidermis development |
| HP:0040211 | 0.00385156742772 | 0.75 | KRT1 DSP KRT5 | Abnormality of the skin of the palm |
| HP:0000962 | 0.00479641167228 | 0.75 | KRT1 DSP KRT5 | Hyperkeratosis |
| HP:0007431 | 0.00626129254237 | 0.5 | KRT1 DSP | Congenital ichthyosiform erythroderma |
| HP:0100871 | 0.00977028900793 | 0.75 | KRT1 DSP KRT5 | Abnormality of the palm |
| HP:0011356 | 0.0104355624072 | 0.75 | KRT1 DSP KRT5 | Regional abnormality of skin |
| HP:0025092 | 0.0142767163782 | 0.5 | KRT1 DSP | Epidermal acanthosis |
| HP:0011368 | 0.0162522818241 | 0.75 | KRT1 DSP KRT5 | Epidermal thickening |
| HP:0001597 | 0.017658912488 | 0.75 | KRT1 DSP KRT5 | Abnormality of the nail |
| HP:0011122 | 0.0178200083076 | 0.75 | KRT1 DSP KRT5 | Abnormality of skin physiology |
| HP:0001072 | 0.0219842049556 | 0.75 | KRT1 DSP KRT5 | Thickened skin |
| GO:0030855 | 0.0258916606244 | 1.0 | KRT1 KRT77 DSP KRT5 | epithelial cell differentiation |
| HP:0011276 | 0.0326278007787 | 0.75 | KRT1 DSP KRT5 | Vascular skin abnormality |
| HP:0011124 | 0.0360996225593 | 0.5 | KRT1 DSP | Abnormality of epidermal morphology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DSP | KRT1 | 0.645 | 0.687 | youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| DSP | KRT5 | 0.4 | 0.56 | youn_WMM gupta_WMM fraction boldt_WMM |
| KRT77 | KRT1 | 0.04 | 0.268 | youn_WMM fraction boldt_WMM |
| DSP | KRT77 | 0.009 | 0.099 | youn_WMM fraction boldt_WMM |
| KRT77 | KRT5 | 0.0 | 0.007 | youn_WMM fraction boldt_WMM |
| KRT1 | KRT5 | 0.0 | 0.001 | youn_WMM gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_04038 has an average edge precision of 0.27 which is ranked 5019 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| KRT1 | HuMAP2_00172 HuMAP2_00512 HuMAP2_01725 HuMAP2_01970 HuMAP2_04038 |
| KRT77 | HuMAP2_00172 HuMAP2_01970 HuMAP2_04038 |
| DSP | HuMAP2_00172 HuMAP2_00512 HuMAP2_01725 HuMAP2_01970 HuMAP2_03046 HuMAP2_04038 |
| KRT5 | HuMAP2_00172 HuMAP2_00512 HuMAP2_01048 HuMAP2_01970 HuMAP2_04038 |