hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04041
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GRIA3 | Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3) | UniProt NCBI |
| GRIA4 | Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4) | UniProt NCBI |
| HECTD4 | NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-399710 | 1.00555407742e-05 | 1.0 | GRIA4 GRIA3 | Activation of AMPA receptors |
| KEGG:05033 | 7.23651818912e-05 | 1.0 | GRIA4 GRIA3 | Nicotine addiction |
| REAC:R-HSA-416993 | 0.000110610948517 | 1.0 | GRIA4 GRIA3 | Trafficking of GluR2-containing AMPA receptors |
| WP:WP2636 | 0.000261924676198 | 1.0 | GRIA4 GRIA3 | Common Pathways Underlying Drug Addiction |
| KEGG:05031 | 0.00027589225596 | 1.0 | GRIA4 GRIA3 | Amphetamine addiction |
| REAC:R-HSA-438066 | 0.000286582912066 | 1.0 | GRIA4 GRIA3 | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-8849932 | 0.000318425457851 | 1.0 | GRIA4 GRIA3 | Synaptic adhesion-like molecules |
| REAC:R-HSA-399721 | 0.000544675125272 | 1.0 | GRIA4 GRIA3 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| REAC:R-HSA-399719 | 0.000544675125272 | 1.0 | GRIA4 GRIA3 | Trafficking of AMPA receptors |
| KEGG:04713 | 0.000558495798951 | 1.0 | GRIA4 GRIA3 | Circadian entrainment |
| WP:WP3584 | 0.000637486658569 | 1.0 | GRIA4 GRIA3 | MECP2 and Associated Rett Syndrome |
| KEGG:04724 | 0.000722192843471 | 1.0 | GRIA4 GRIA3 | Glutamatergic synapse |
| KEGG:04728 | 0.00105921617042 | 1.0 | GRIA4 GRIA3 | Dopaminergic synapse |
| KEGG:04723 | 0.0012614301666 | 1.0 | GRIA4 GRIA3 | Retrograde endocannabinoid signaling |
| KEGG:04024 | 0.00209581822151 | 1.0 | GRIA4 GRIA3 | cAMP signaling pathway |
| KEGG:04080 | 0.00232429377562 | 1.0 | GRIA4 GRIA3 | Neuroactive ligand-receptor interaction |
| GO:0004971 | 0.00270494046827 | 1.0 | GRIA4 GRIA3 | AMPA glutamate receptor activity |
| REAC:R-HSA-6794362 | 0.00542999201809 | 1.0 | GRIA4 GRIA3 | Protein-protein interactions at synapses |
| REAC:R-HSA-442755 | 0.00584226918984 | 1.0 | GRIA4 GRIA3 | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-112314 | 0.0255159347147 | 1.0 | GRIA4 GRIA3 | Neurotransmitter receptors and postsynaptic signal transmission |
| GO:0032281 | 0.0351642260875 | 1.0 | GRIA4 GRIA3 | AMPA glutamate receptor complex |
| REAC:R-HSA-112315 | 0.0429891127334 | 1.0 | GRIA4 GRIA3 | Transmission across Chemical Synapses |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GRIA4 | GRIA3 | 1.0 | 0.949 | bioplex (GRIA3) bioplex_WMM |
| HECTD4 | GRIA3 | 0.805 | 0.767 | bioplex (GRIA3) bioplex_WMM |
| HECTD4 | GRIA4 | 0.008 | 0.095 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04041 has an average edge precision of 0.604 which is ranked 1925 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GRIA3 | HuMAP2_04041 |
| GRIA4 | HuMAP2_04041 |
| HECTD4 | HuMAP2_03540 HuMAP2_04041 |