hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04052
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) | UniProt NCBI |
| BLVRB | Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) | UniProt NCBI |
| RAC3 | Ras-related C3 botulinum toxin substrate 3 (p21-Rac3) | UniProt NCBI |
| RAC2 | Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2290 | 4.96174655228e-08 | 0.75 | RAC2 RAC3 RAC1 | RalA downstream regulated genes |
| WP:WP3937 | 9.14837263068e-07 | 0.75 | RAC2 RAC3 RAC1 | Microglia Pathogen Phagocytosis Pathway |
| KEGG:05416 | 4.07597108673e-06 | 0.75 | RAC2 RAC3 RAC1 | Viral myocarditis |
| KEGG:04664 | 7.04114124692e-06 | 0.75 | RAC2 RAC3 RAC1 | Fc epsilon RI signaling pathway |
| KEGG:04370 | 7.04114124692e-06 | 0.75 | RAC2 RAC3 RAC1 | VEGF signaling pathway |
| KEGG:04662 | 1.28493032652e-05 | 0.75 | RAC2 RAC3 RAC1 | B cell receptor signaling pathway |
| WP:WP4216 | 1.28520696315e-05 | 0.75 | RAC2 RAC3 RAC1 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:04520 | 1.40519436497e-05 | 0.75 | RAC2 RAC3 RAC1 | Adherens junction |
| KEGG:05212 | 1.5327283042e-05 | 0.75 | RAC2 RAC3 RAC1 | Pancreatic cancer |
| WP:WP4263 | 2.06481472174e-05 | 0.75 | RAC2 RAC3 RAC1 | Pancreatic adenocarcinoma pathway |
| KEGG:05210 | 2.37359736806e-05 | 0.75 | RAC2 RAC3 RAC1 | Colorectal cancer |
| WP:WP185 | 2.91471848583e-05 | 0.75 | RAC2 RAC3 RAC1 | Integrin-mediated Cell Adhesion |
| KEGG:05231 | 3.04268063402e-05 | 0.75 | RAC2 RAC3 RAC1 | Choline metabolism in cancer |
| WP:WP710 | 4.08802374395e-05 | 0.75 | RAC2 RAC3 RAC1 | DNA Damage Response (only ATM dependent) |
| KEGG:04650 | 4.20027475005e-05 | 0.75 | RAC2 RAC3 RAC1 | Natural killer cell mediated cytotoxicity |
| KEGG:04071 | 5.61899791571e-05 | 0.75 | RAC2 RAC3 RAC1 | Sphingolipid signaling pathway |
| KEGG:05135 | 6.09947630131e-05 | 0.75 | RAC2 RAC3 RAC1 | Yersinia infection |
| WP:WP51 | 8.39876098155e-05 | 0.75 | RAC2 RAC3 RAC1 | Regulation of Actin Cytoskeleton |
| KEGG:05418 | 8.49786152038e-05 | 0.75 | RAC2 RAC3 RAC1 | Fluid shear stress and atherosclerosis |
| KEGG:04062 | 9.56545898299e-05 | 0.75 | RAC2 RAC3 RAC1 | Chemokine signaling pathway |
| WP:WP4223 | 0.000136289943844 | 0.75 | RAC2 RAC3 RAC1 | Ras Signaling |
| KEGG:04310 | 0.000138556392266 | 0.75 | RAC2 RAC3 RAC1 | Wnt signaling pathway |
| REAC:R-HSA-4086400 | 0.000163333735977 | 0.75 | RAC2 RAC3 RAC1 | PCP/CE pathway |
| KEGG:04360 | 0.000196203606831 | 0.75 | RAC2 RAC3 RAC1 | Axon guidance |
| KEGG:04024 | 0.000214647688386 | 0.75 | RAC2 RAC3 RAC1 | cAMP signaling pathway |
| KEGG:04015 | 0.000226248540233 | 0.75 | RAC2 RAC3 RAC1 | Rap1 signaling pathway |
| WP:WP306 | 0.00024361518378 | 0.75 | RAC2 RAC3 RAC1 | Focal Adhesion |
| KEGG:04014 | 0.00027234077557 | 0.75 | RAC2 RAC3 RAC1 | Ras signaling pathway |
| KEGG:04810 | 0.000285912023079 | 0.75 | RAC2 RAC3 RAC1 | Regulation of actin cytoskeleton |
| KEGG:04510 | 0.000295204681571 | 0.75 | RAC2 RAC3 RAC1 | Focal adhesion |
| KEGG:05170 | 0.000344687561831 | 0.75 | RAC2 RAC3 RAC1 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.000360539009602 | 0.75 | RAC2 RAC3 RAC1 | Human cytomegalovirus infection |
| WP:WP382 | 0.000385360586168 | 0.75 | RAC2 RAC3 RAC1 | MAPK Signaling Pathway |
| REAC:R-HSA-194840 | 0.000491277204617 | 0.75 | RAC2 RAC3 RAC1 | Rho GTPase cycle |
| REAC:R-HSA-3858494 | 0.000562319812212 | 0.75 | RAC2 RAC3 RAC1 | Beta-catenin independent WNT signaling |
| KEGG:04010 | 0.000734165415649 | 0.75 | RAC2 RAC3 RAC1 | MAPK signaling pathway |
| REAC:R-HSA-5668599 | 0.00171688133139 | 0.5 | RAC2 RAC1 | RHO GTPases Activate NADPH Oxidases |
| REAC:R-HSA-114604 | 0.00379215175563 | 0.5 | RAC2 RAC1 | GPVI-mediated activation cascade |
| KEGG:05200 | 0.00437599198048 | 0.75 | RAC2 RAC3 RAC1 | Pathways in cancer |
| WP:WP4298 | 0.0046318251922 | 0.5 | RAC2 RAC3 | Viral Acute Myocarditis |
| WP:WP23 | 0.0063819591539 | 0.5 | RAC2 RAC1 | B Cell Receptor Signaling Pathway |
| REAC:R-HSA-195721 | 0.00653784113487 | 0.75 | RAC2 RAC3 RAC1 | Signaling by WNT |
| KEGG:04670 | 0.00761107721317 | 0.5 | RAC2 RAC1 | Leukocyte transendothelial migration |
| KEGG:04666 | 0.00761107721317 | 0.5 | RAC2 RAC1 | Fc gamma R-mediated phagocytosis |
| REAC:R-HSA-2219530 | 0.00991669978918 | 0.5 | RAC2 RAC1 | Constitutive Signaling by Aberrant PI3K in Cancer |
| WP:WP3929 | 0.012672821387 | 0.5 | RAC2 RAC1 | Chemokine signaling pathway |
| REAC:R-HSA-194315 | 0.0173883634433 | 0.75 | RAC2 RAC3 RAC1 | Signaling by Rho GTPases |
| WP:WP481 | 0.0195247658454 | 0.5 | RAC2 RAC1 | Insulin Signaling |
| REAC:R-HSA-6811558 | 0.0234490216385 | 0.5 | RAC2 RAC1 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-2219528 | 0.0248339118539 | 0.5 | RAC2 RAC1 | PI3K/AKT Signaling in Cancer |
| REAC:R-HSA-199418 | 0.0284687652941 | 0.5 | RAC2 RAC1 | Negative regulation of the PI3K/AKT network |
| WP:WP3943 | 0.0416857670091 | 0.25 | RAC1 | Robo4 and VEGF Signaling Pathways Crosstalk |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAC3 | RAC2 | 0.94 | 0.852 | bioplex (RAC2) bioplex_WMM |
| RAC3 | RAC1 | 0.171 | 0.43 | bioplex (RAC1) bioplex_WMM |
| BLVRB | RAC1 | 0.071 | 0.351 | bioplex_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_04052 has an average edge precision of 0.544 which is ranked 2236 out of all 6965 complexes.
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