hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04054
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NELFB | Negative elongation factor B (NELF-B) (Cofactor of BRCA1) | UniProt NCBI |
| NELFE | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:281 | 1.00555407742e-05 | 1.0 | NELFB NELFE | NELF complex (Negative elongation factor complex) |
| CORUM:2598 | 1.00555407742e-05 | 1.0 | NELFB NELFE | NELF complex (Negative elongation factor complex) |
| WP:WP3414 | 0.000162072879297 | 1.0 | NELFB NELFE | Initiation of transcription and translation elongation at the HIV-1 LTR |
| REAC:R-HSA-167242 | 0.000424008635981 | 1.0 | NELFB NELFE | Abortive elongation of HIV-1 transcript in the absence of Tat |
| REAC:R-HSA-167243 | 0.000831258037338 | 1.0 | NELFB NELFE | Tat-mediated HIV elongation arrest and recovery |
| REAC:R-HSA-167238 | 0.000831258037338 | 1.0 | NELFB NELFE | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-113418 | 0.000884887588134 | 1.0 | NELFB NELFE | Formation of the Early Elongation Complex |
| REAC:R-HSA-167158 | 0.000884887588134 | 1.0 | NELFB NELFE | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-167290 | 0.000940193062392 | 1.0 | NELFB NELFE | Pausing and recovery of HIV elongation |
| REAC:R-HSA-167287 | 0.000940193062392 | 1.0 | NELFB NELFE | HIV elongation arrest and recovery |
| REAC:R-HSA-167169 | 0.00158542359541 | 1.0 | NELFB NELFE | HIV Transcription Elongation |
| REAC:R-HSA-167200 | 0.00158542359541 | 1.0 | NELFB NELFE | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167246 | 0.00158542359541 | 1.0 | NELFB NELFE | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167152 | 0.00173458078356 | 1.0 | NELFB NELFE | Formation of HIV elongation complex in the absence of HIV Tat |
| GO:0032021 | 0.00270494046827 | 1.0 | NELFB NELFE | NELF complex |
| REAC:R-HSA-112382 | 0.00286750504412 | 1.0 | NELFB NELFE | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-75955 | 0.00286750504412 | 1.0 | NELFB NELFE | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-6796648 | 0.00316917126735 | 1.0 | NELFB NELFE | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-167172 | 0.004164669804 | 1.0 | NELFB NELFE | Transcription of the HIV genome |
| REAC:R-HSA-674695 | 0.00556574181855 | 1.0 | NELFB NELFE | RNA Polymerase II Pre-transcription Events |
| REAC:R-HSA-162599 | 0.0147112561527 | 1.0 | NELFB NELFE | Late Phase of HIV Life Cycle |
| GO:0034244 | 0.0162296428096 | 1.0 | NELFB NELFE | negative regulation of transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-162587 | 0.0177396498492 | 1.0 | NELFB NELFE | HIV Life Cycle |
| GO:0032785 | 0.0247952876258 | 1.0 | NELFB NELFE | negative regulation of DNA-templated transcription, elongation |
| REAC:R-HSA-162906 | 0.0414841334642 | 1.0 | NELFB NELFE | HIV Infection |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NELFB | NELFE | 1.0 | 0.949 | hein_WMM bioplex (NELFE) bioplex_WMM youn_WMM hein (NELFE) gupta_WMM fraction |
Images
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Complex HuMAP2_04054 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NELFB | HuMAP2_01553 HuMAP2_04054 HuMAP2_04651 HuMAP2_05614 HuMAP2_06018 |
| NELFE | HuMAP2_04054 HuMAP2_04651 HuMAP2_05614 HuMAP2_06018 |