hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04058
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GSTM3 | Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3) | UniProt NCBI |
| GSTM2 | Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST class-mu 2) (GSTM2-2) | UniProt NCBI |
| SLBP | Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) | UniProt NCBI |
| GSTM5 | Glutathione S-transferase Mu 5 (EC 2.5.1.18) (GST class-mu 5) (GSTM5-5) | UniProt NCBI |
| GSTM4 | Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-156590 | 1.69093561494e-08 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Glutathione conjugation |
| KEGG:00480 | 2.45539862476e-08 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Glutathione metabolism |
| KEGG:00982 | 5.64777967131e-08 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Drug metabolism - cytochrome P450 |
| KEGG:00980 | 7.35732696542e-08 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:05204 | 1.00077786255e-07 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Chemical carcinogenesis |
| KEGG:01524 | 1.1907721613e-07 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Platinum drug resistance |
| KEGG:00983 | 1.1907721613e-07 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Drug metabolism - other enzymes |
| WP:WP2884 | 5.38019281783e-07 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | NRF2 pathway |
| GO:1901687 | 7.29370383293e-07 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | glutathione derivative biosynthetic process |
| GO:1901685 | 7.29370383293e-07 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | glutathione derivative metabolic process |
| GO:0004364 | 8.91404751529e-07 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | glutathione transferase activity |
| KEGG:05418 | 1.11852153694e-06 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Fluid shear stress and atherosclerosis |
| REAC:R-HSA-156580 | 1.15695586407e-06 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Phase II - Conjugation of compounds |
| WP:WP702 | 2.29711341652e-06 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Metapathway biotransformation Phase I and II |
| KEGG:05225 | 2.95343153553e-06 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Hepatocellular carcinoma |
| GO:0006749 | 1.36251014669e-05 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | glutathione metabolic process |
| WP:WP2882 | 1.60731600076e-05 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Nuclear Receptors Meta-Pathway |
| REAC:R-HSA-211859 | 1.78392279875e-05 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Biological oxidations |
| GO:0016765 | 2.57816855599e-05 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| GO:0042178 | 3.17736949706e-05 | 0.6 | GSTM3 GSTM2 GSTM4 | xenobiotic catabolic process |
| GO:0045171 | 4.1487149847e-05 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | intercellular bridge |
| GO:0043295 | 7.62415024416e-05 | 0.6 | GSTM3 GSTM2 GSTM4 | glutathione binding |
| GO:1900750 | 0.000108905457596 | 0.6 | GSTM3 GSTM2 GSTM4 | oligopeptide binding |
| KEGG:05200 | 0.000217862252065 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Pathways in cancer |
| GO:0006575 | 0.00196556700855 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | cellular modified amino acid metabolic process |
| GO:0044272 | 0.00279846120143 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | sulfur compound biosynthetic process |
| KEGG:01100 | 0.0121945453342 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | Metabolic pathways |
| GO:0018916 | 0.0135228859698 | 0.4 | GSTM3 GSTM2 | nitrobenzene metabolic process |
| GO:0070458 | 0.0135228859698 | 0.4 | GSTM3 GSTM2 | cellular detoxification of nitrogen compound |
| GO:0072341 | 0.0278679504637 | 0.6 | GSTM3 GSTM2 GSTM4 | modified amino acid binding |
| GO:0006790 | 0.0376297096835 | 0.8 | GSTM3 GSTM4 GSTM2 GSTM5 | sulfur compound metabolic process |
| GO:0051410 | 0.0450641792523 | 0.4 | GSTM3 GSTM2 | detoxification of nitrogen compound |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GSTM2 | GSTM4 | 1.0 | 0.949 | bioplex (GSTM2) bioplex_WMM |
| GSTM5 | GSTM4 | 1.0 | 0.949 | bioplex (GSTM5) bioplex_WMM |
| GSTM3 | GSTM5 | 0.996 | 0.927 | bioplex (GSTM5) bioplex_WMM |
| GSTM3 | GSTM4 | 0.937 | 0.85 | bioplex (GSTM3) bioplex_WMM |
| GSTM2 | GSTM5 | 0.827 | 0.774 | bioplex (GSTM2,GSTM5) bioplex_WMM |
| GSTM3 | GSTM2 | 0.448 | 0.592 | bioplex (GSTM2,GSTM3) bioplex_WMM |
| GSTM3 | SLBP | 0.121 | 0.393 | bioplex (GSTM3) bioplex_WMM |
| GSTM2 | SLBP | 0.008 | 0.095 | bioplex_WMM WMM_only |
| GSTM4 | SLBP | 0.008 | 0.091 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04058 has an average edge precision of 0.624 which is ranked 1806 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GSTM3 | HuMAP2_00158 HuMAP2_04058 |
| GSTM2 | HuMAP2_00158 HuMAP2_04058 |
| SLBP | HuMAP2_03451 HuMAP2_04058 HuMAP2_06072 |
| GSTM5 | HuMAP2_00158 HuMAP2_04058 |
| GSTM4 | HuMAP2_00158 HuMAP2_04058 |