hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04063
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NPLOC4 | Nuclear protein localization protein 4 homolog (Protein NPL4) | UniProt NCBI |
| UFD1 | Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1) | UniProt NCBI |
| PRRC1 | Protein PRRC1 (Proline-rich and coiled-coil-containing protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6280 | 2.01342304124e-05 | 0.666666666667 | NPLOC4 UFD1 | NUB1L-UFD1-NPL4-NEDD8 complex |
| REAC:R-HSA-110320 | 0.00114404160216 | 0.666666666667 | NPLOC4 UFD1 | Translesion Synthesis by POLH |
| GO:0036501 | 0.00135247023414 | 0.666666666667 | NPLOC4 UFD1 | UFD1-NPL4 complex |
| REAC:R-HSA-110313 | 0.0046992786316 | 0.666666666667 | NPLOC4 UFD1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| KEGG:04141 | 0.00544616782939 | 0.666666666667 | NPLOC4 UFD1 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-73893 | 0.00722314394396 | 0.666666666667 | NPLOC4 UFD1 | DNA Damage Bypass |
| GO:0039536 | 0.0135228859698 | 0.666666666667 | NPLOC4 UFD1 | negative regulation of RIG-I signaling pathway |
| GO:0034098 | 0.0283955176165 | 0.666666666667 | NPLOC4 UFD1 | VCP-NPL4-UFD1 AAA ATPase complex |
| GO:0039532 | 0.0378589948753 | 0.666666666667 | NPLOC4 UFD1 | negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UFD1 | NPLOC4 | 1.0 | 0.949 | bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction |
| NPLOC4 | PRRC1 | 0.045 | 0.283 | youn_WMM fraction |
| UFD1 | PRRC1 | 0.013 | 0.147 | youn_WMM fraction |
Images
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Complex HuMAP2_04063 has an average edge precision of 0.46 which is ranked 2802 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NPLOC4 | HuMAP2_02799 HuMAP2_04063 HuMAP2_06192 |
| UFD1 | HuMAP2_02054 HuMAP2_02799 HuMAP2_04063 HuMAP2_06192 |
| PRRC1 | HuMAP2_04063 |