hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04067
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GFM1 | Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (hEFG1) | UniProt NCBI |
| MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) | UniProt NCBI |
| MCCC1 | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) | UniProt NCBI |
| DPP9 | Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7190 | 5.02777038712e-06 | 0.5 | MCCC1 MCCC2 | 3-methylcrotonyl-CoA carboxylase |
| HP:0004357 | 2.27305921704e-05 | 0.5 | MCCC1 MCCC2 | Abnormal circulating leucine concentration |
| HP:0008281 | 0.000136359131835 | 0.5 | MCCC1 MCCC2 | Acute hyperammonemia |
| REAC:R-HSA-3371599 | 0.000211071833435 | 0.5 | MCCC1 MCCC2 | Defective HLCS causes multiple carboxylase deficiency |
| REAC:R-HSA-3323169 | 0.000281403908969 | 0.5 | MCCC1 MCCC2 | Defects in biotin (Btn) metabolism |
| HP:0001942 | 0.000322204655363 | 0.75 | GFM1 MCCC2 MCCC1 | Metabolic acidosis |
| HP:0010892 | 0.000477128766336 | 0.5 | MCCC1 MCCC2 | Abnormal circulating branched chain amino acid concentration |
| REAC:R-HSA-196780 | 0.000552609179875 | 0.5 | MCCC1 MCCC2 | Biotin transport and metabolism |
| REAC:R-HSA-70895 | 0.00171688133139 | 0.5 | MCCC1 MCCC2 | Branched-chain amino acid catabolism |
| REAC:R-HSA-3296482 | 0.00210807296175 | 0.5 | MCCC1 MCCC2 | Defects in vitamin and cofactor metabolism |
| KEGG:00280 | 0.00215723904775 | 0.5 | MCCC1 MCCC2 | Valine, leucine and isoleucine degradation |
| GO:0004485 | 0.00270494046827 | 0.5 | MCCC1 MCCC2 | methylcrotonoyl-CoA carboxylase activity |
| GO:1905202 | 0.00270494046827 | 0.5 | MCCC1 MCCC2 | methylcrotonoyl-CoA carboxylase complex |
| GO:0002169 | 0.00270494046827 | 0.5 | MCCC1 MCCC2 | 3-methylcrotonyl-CoA carboxylase complex, mitochondrial |
| HP:0002919 | 0.0038810174634 | 0.5 | MCCC1 MCCC2 | Ketonuria |
| HP:0002179 | 0.00920632571228 | 0.5 | MCCC1 MCCC2 | Opisthotonus |
| HP:0001941 | 0.0114887691482 | 0.75 | GFM1 MCCC2 MCCC1 | Acidosis |
| HP:0004360 | 0.014922003471 | 0.75 | GFM1 MCCC2 MCCC1 | Abnormality of acid-base homeostasis |
| HP:0001987 | 0.023433582519 | 0.5 | MCCC1 MCCC2 | Hyperammonemia |
| GO:0006552 | 0.0270421395626 | 0.5 | MCCC1 MCCC2 | leucine catabolic process |
| REAC:R-HSA-5668914 | 0.0381968559025 | 0.5 | MCCC1 MCCC2 | Diseases of metabolism |
| HP:0025032 | 0.0398318494323 | 1.0 | GFM1 DPP9 MCCC2 MCCC1 | Abnormality of digestive system physiology |
| GO:0016421 | 0.0405595771497 | 0.5 | MCCC1 MCCC2 | CoA carboxylase activity |
| HP:0001992 | 0.0441507593067 | 0.5 | MCCC1 MCCC2 | Organic aciduria |
| HP:0001531 | 0.048478178044 | 0.5 | MCCC1 MCCC2 | Failure to thrive in infancy |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MCCC2 | MCCC1 | 1.0 | 0.949 | bioplex_WMM Guru boldt Malo fraction boldt_WMM treiber_WMM |
| GFM1 | MCCC2 | 0.032 | 0.241 | bioplex_WMM fraction |
| GFM1 | DPP9 | 0.029 | 0.232 | bioplex_WMM fraction treiber_WMM |
| DPP9 | MCCC1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| DPP9 | MCCC2 | 0.006 | 0.004 | bioplex_WMM WMM_only |
| GFM1 | MCCC1 | 0.003 | 0.011 | bioplex_WMM fraction |
Images
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Complex HuMAP2_04067 has an average edge precision of 0.24 which is ranked 5530 out of all 6965 complexes.
Related Complexes