hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04070

Confidence: Medium High

Genename	Protein Name	Links
SLX4	Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)	UniProt NCBI
ERCC4	DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein)	UniProt NCBI
SLX4IP	Protein SLX4IP (SLX4-interacting protein)	UniProt NCBI
ERCC1	DNA excision repair protein ERCC-1	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0070522	3.63274304092e-07	0.75	ERCC1 ERCC4 SLX4	ERCC4-ERCC1 complex
KEGG:03460	4.94626613091e-06	0.75	ERCC1 ERCC4 SLX4	Fanconi anemia pathway
REAC:R-HSA-6783310	8.82452886806e-06	0.75	ERCC1 ERCC4 SLX4	Fanconi Anemia Pathway
CORUM:2220	1.50819606993e-05	0.5	ERCC1 ERCC4	RAD52-ERCC4-ERCC1 complex
CORUM:531	1.50819606993e-05	0.5	ERCC1 ERCC4	XPA-ERCC1-ERCC4 complex
CORUM:368	1.50819606993e-05	0.5	ERCC1 ERCC4	ERCC1-ERCC4-MSH2 complex
GO:0000109	5.99161085695e-05	0.75	ERCC1 ERCC4 SLX4	nucleotide-excision repair complex
REAC:R-HSA-5693567	0.000480050915503	0.75	ERCC1 ERCC4 SLX4	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
REAC:R-HSA-5693538	0.000550034129522	0.75	ERCC1 ERCC4 SLX4	Homology Directed Repair
REAC:R-HSA-5693532	0.000966811034897	0.75	ERCC1 ERCC4 SLX4	DNA Double-Strand Break Repair
KEGG:03420	0.00188834163584	0.5	ERCC1 ERCC4	Nucleotide excision repair
GO:1990391	0.00197902980402	0.75	ERCC1 ERCC4 SLX4	DNA repair complex
HP:0002818	0.00202891029227	0.75	ERCC1 ERCC4 SLX4	Abnormality of the radius
GO:0004520	0.00237379826551	0.75	ERCC1 ERCC4 SLX4	endodeoxyribonuclease activity
GO:0032205	0.00237379826551	0.75	ERCC1 ERCC4 SLX4	negative regulation of telomere maintenance
HP:0040072	0.00247843647398	0.75	ERCC1 ERCC4 SLX4	Abnormality of forearm bone
HP:0002973	0.00256668512029	0.75	ERCC1 ERCC4 SLX4	Abnormality of the forearm
GO:1905764	0.00270494046827	0.5	ERCC1 ERCC4	regulation of protection from non-homologous end joining at telomere
GO:1905765	0.00270494046827	0.5	ERCC1 ERCC4	negative regulation of protection from non-homologous end joining at telomere
GO:1990599	0.00270494046827	0.5	ERCC1 ERCC4	3' overhang single-stranded DNA endodeoxyribonuclease activity
GO:0061819	0.00270494046827	0.5	ERCC1 ERCC4	telomeric DNA-containing double minutes formation
HP:0002827	0.00303936111734	0.75	ERCC1 ERCC4 SLX4	Hip dislocation
HP:0200007	0.00362241862944	0.75	ERCC1 ERCC4 SLX4	Abnormal size of the palpebral fissures
HP:0000568	0.00391032107959	0.75	ERCC1 ERCC4 SLX4	Microphthalmia
HP:0005522	0.00476530778748	0.5	ERCC4 SLX4	Pyridoxine-responsive sideroblastic anemia
HP:0030311	0.00507203261353	0.75	ERCC1 ERCC4 SLX4	Lower extremity joint dislocation
HP:0010469	0.00524136889643	0.5	ERCC4 SLX4	Absent testis
HP:0010293	0.00524136889643	0.5	ERCC4 SLX4	Aplasia/Hypoplasia of the uvula
HP:0009777	0.00524136889643	0.5	ERCC4 SLX4	Absent thumb
HP:0100887	0.00528551172659	0.75	ERCC1 ERCC4 SLX4	Abnormality of globe size
GO:0036297	0.0062689516986	0.75	ERCC1 ERCC4 SLX4	interstrand cross-link repair
HP:0001384	0.00627960088635	0.75	ERCC1 ERCC4 SLX4	Abnormality of the hip joint
REAC:R-HSA-5685938	0.00631572211528	0.5	ERCC1 ERCC4	HDR through Single Strand Annealing (SSA)
HP:0100867	0.00680514289491	0.5	ERCC4 SLX4	Duodenal stenosis
HP:0012848	0.00680514289491	0.5	ERCC4 SLX4	Small intestinal stenosis
HP:0100587	0.00680514289491	0.5	ERCC4 SLX4	Abnormality of the preputium
HP:0005262	0.00686289442735	0.75	ERCC1 ERCC4 SLX4	Abnormality of the synovia
REAC:R-HSA-73894	0.00725712676591	0.75	ERCC1 ERCC4 SLX4	DNA Repair
HP:0100760	0.00737157747856	0.5	ERCC4 SLX4	Clubbing of toes
GO:0004536	0.0080085486554	0.75	ERCC1 ERCC4 SLX4	deoxyribonuclease activity
GO:1904506	0.00811409485621	0.5	ERCC1 ERCC4	negative regulation of telomere maintenance in response to DNA damage
GO:1904505	0.00811409485621	0.5	ERCC1 ERCC4	regulation of telomere maintenance in response to DNA damage
GO:0000110	0.00811409485621	0.5	ERCC1 ERCC4	nucleotide-excision repair factor 1 complex
REAC:R-HSA-5696400	0.00821677913545	0.5	ERCC1 ERCC4	Dual Incision in GG-NER
HP:0001172	0.00872511283479	0.75	ERCC1 ERCC4 SLX4	Abnormal thumb morphology
REAC:R-HSA-5696395	0.00904685478976	0.5	ERCC1 ERCC4	Formation of Incision Complex in GG-NER
HP:0007874	0.00920632571228	0.5	ERCC4 SLX4	Almond-shaped palpebral fissure
HP:0200005	0.00920632571228	0.5	ERCC4 SLX4	Abnormal shape of the palpebral fissure
HP:0001924	0.0105423007107	0.5	ERCC4 SLX4	Sideroblastic anemia
HP:0001373	0.0117320060244	0.75	ERCC1 ERCC4 SLX4	Joint dislocation
HP:0000135	0.012868880828	0.75	ERCC1 ERCC4 SLX4	Hypogonadism
HP:0003220	0.0159281461127	0.5	ERCC4 SLX4	Abnormality of chromosome stability
HP:0000813	0.0159281461127	0.5	ERCC4 SLX4	Bicornuate uterus
GO:1904431	0.0162267366884	0.5	ERCC1 SLX4	positive regulation of t-circle formation
HP:0008056	0.0167125722923	0.75	ERCC1 ERCC4 SLX4	Aplasia/Hypoplasia affecting the eye
HP:0040070	0.0173396229329	0.75	ERCC1 ERCC4 SLX4	Abnormal upper limb bone morphology
HP:0009380	0.0176695962482	0.5	ERCC4 SLX4	Aplasia of the fingers
GO:0061982	0.0198185309013	0.75	ERCC1 ERCC4 SLX4	meiosis I cell cycle process
REAC:R-HSA-6782135	0.0207977326435	0.5	ERCC1 ERCC4	Dual incision in TC-NER
HP:0001199	0.0214223630957	0.5	ERCC4 SLX4	Triphalangeal thumb
HP:0100026	0.0224167415402	0.5	ERCC4 SLX4	Arteriovenous malformation
HP:0003272	0.0236980209279	0.75	ERCC1 ERCC4 SLX4	Abnormality of the hip bone
GO:0032204	0.0254442868917	0.75	ERCC1 ERCC4 SLX4	regulation of telomere maintenance
HP:0000072	0.0266188198793	0.5	ERCC4 SLX4	Hydroureter
HP:0040071	0.0277254502169	0.5	ERCC4 SLX4	Abnormal morphology of ulna
HP:0003022	0.0277254502169	0.5	ERCC4 SLX4	Hypoplasia of the ulna
HP:0001511	0.0289176088458	0.75	ERCC1 ERCC4 SLX4	Intrauterine growth retardation
REAC:R-HSA-6781827	0.0299917015228	0.5	ERCC1 ERCC4	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
HP:0007565	0.0311799098191	0.5	ERCC4 SLX4	Multiple cafe-au-lait spots
HP:0005344	0.0323762323007	0.5	ERCC4 SLX4	Abnormal carotid artery morphology
HP:0002246	0.0323762323007	0.5	ERCC4 SLX4	Abnormality of the duodenum
HP:0002860	0.0335949626331	0.5	ERCC4 SLX4	Squamous cell carcinoma
HP:0012041	0.0335949626331	0.5	ERCC4 SLX4	Decreased fertility in males
REAC:R-HSA-5696399	0.0347967852364	0.5	ERCC1 ERCC4	Global Genome Nucleotide Excision Repair (GG-NER)
HP:0002245	0.0348360947433	0.5	ERCC4 SLX4	Meckel diverticulum
HP:0006495	0.0348360947433	0.5	ERCC4 SLX4	Aplasia/Hypoplasia of the ulna
HP:0002644	0.0371635460631	0.75	ERCC1 ERCC4 SLX4	Abnormality of pelvic girdle bone morphology
HP:0001549	0.0373855400094	0.5	ERCC4 SLX4	Abnormal ileum morphology
HP:0000080	0.0406864321028	0.75	ERCC1 ERCC4 SLX4	Abnormality of reproductive system physiology
HP:0002863	0.0427529847392	0.5	ERCC4 SLX4	Myelodysplasia
GO:0000726	0.0439367749778	0.75	ERCC1 ERCC4 SLX4	non-recombinational repair
GO:0004519	0.0439367749778	0.75	ERCC1 ERCC4 SLX4	endonuclease activity
HP:0002575	0.0455708870915	0.5	ERCC4 SLX4	Tracheoesophageal fistula
HP:0100491	0.0471392817231	0.75	ERCC1 ERCC4 SLX4	Abnormality of lower limb joint
HP:0009821	0.049965329079	0.5	ERCC4 SLX4	Forearm undergrowth

Edges

Protein 1	Protein 2	Score	Precision	Evidence
ERCC4	ERCC1	1.0	0.949	bioplex (ERCC1) bioplex_WMM youn_WMM Malo fraction
SLX4	ERCC1	0.997	0.93	bioplex (ERCC1) bioplex_WMM
ERCC1	SLX4IP	0.202	0.451	bioplex (ERCC1) bioplex_WMM
ERCC4	SLX4	0.009	0.109	hein_WMM bioplex_WMM WMM_only
SLX4	SLX4IP	0.009	0.094	bioplex_WMM WMM_only
ERCC4	SLX4IP	0.008	0.029	bioplex_WMM WMM_only

Images

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Complex HuMAP2_04070 has an average edge precision of 0.427 which is ranked 3052 out of all 6965 complexes.

Related Complexes

Genename	Complexes
SLX4	HuMAP2_00595 HuMAP2_04070 HuMAP2_05771
ERCC4	HuMAP2_00595 HuMAP2_00777 HuMAP2_02823 HuMAP2_03411 HuMAP2_04070 HuMAP2_04705 HuMAP2_05771
SLX4IP	HuMAP2_01116 HuMAP2_04070 HuMAP2_05771
ERCC1	HuMAP2_00595 HuMAP2_04070 HuMAP2_05771

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04070