hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04072
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TIMP1 | Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1) | UniProt NCBI |
| MMP9 | Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9] | UniProt NCBI |
| COL14A1 | Collagen alpha-1(XIV) chain (Undulin) | UniProt NCBI |
| COL12A1 | Collagen alpha-1(XII) chain | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1474228 | 9.67478990718e-07 | 1.0 | COL12A1 COL14A1 MMP9 TIMP1 | Degradation of the extracellular matrix |
| CORUM:2709 | 1.50819606993e-05 | 0.5 | TIMP1 MMP9 | MMP-9-TIMP-1-LRP complex |
| REAC:R-HSA-1474244 | 1.8775434359e-05 | 1.0 | COL12A1 COL14A1 MMP9 TIMP1 | Extracellular matrix organization |
| REAC:R-HSA-2022090 | 3.73348809378e-05 | 0.75 | COL14A1 MMP9 COL12A1 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1442490 | 4.60801423694e-05 | 0.75 | COL14A1 MMP9 COL12A1 | Collagen degradation |
| REAC:R-HSA-1474290 | 0.00012815247216 | 0.75 | COL14A1 MMP9 COL12A1 | Collagen formation |
| WP:WP2865 | 0.000318702346676 | 0.5 | TIMP1 MMP9 | IL1 and megakaryocytes in obesity |
| WP:WP129 | 0.000588391449758 | 0.5 | TIMP1 MMP9 | Matrix Metalloproteinases |
| WP:WP3624 | 0.00130601363574 | 0.5 | TIMP1 MMP9 | Lung fibrosis |
| GO:0030198 | 0.00406662724791 | 1.0 | COL12A1 COL14A1 MMP9 TIMP1 | extracellular matrix organization |
| REAC:R-HSA-1592389 | 0.00466369436644 | 0.5 | TIMP1 MMP9 | Activation of Matrix Metalloproteinases |
| KEGG:04974 | 0.0055238804144 | 0.5 | COL14A1 COL12A1 | Protein digestion and absorption |
| GO:0043062 | 0.00733907004762 | 1.0 | COL12A1 COL14A1 MMP9 TIMP1 | extracellular structure organization |
| REAC:R-HSA-8948216 | 0.00742649434549 | 0.5 | COL14A1 COL12A1 | Collagen chain trimerization |
| GO:0030934 | 0.00811409485621 | 0.5 | COL14A1 COL12A1 | anchoring collagen complex |
| GO:0031012 | 0.0175518684514 | 1.0 | COL12A1 COL14A1 MMP9 TIMP1 | extracellular matrix |
| REAC:R-HSA-1650814 | 0.0189130304237 | 0.5 | COL14A1 COL12A1 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-6785807 | 0.0381968559025 | 0.5 | TIMP1 MMP9 | Interleukin-4 and Interleukin-13 signaling |
| GO:0005593 | 0.0405595771497 | 0.5 | COL14A1 COL12A1 | FACIT collagen trimer |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MMP9 | TIMP1 | 0.33 | 0.52 | bioplex (MMP9) bioplex_WMM |
| COL12A1 | MMP9 | 0.137 | 0.407 | bioplex (MMP9) bioplex_WMM |
| MMP9 | COL14A1 | 0.093 | 0.355 | bioplex (MMP9) bioplex_WMM |
| COL12A1 | COL14A1 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| COL12A1 | TIMP1 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| TIMP1 | COL14A1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04072 has an average edge precision of 0.235 which is ranked 5607 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TIMP1 | HuMAP2_01361 HuMAP2_04072 HuMAP2_05564 HuMAP2_06424 |
| MMP9 | HuMAP2_01361 HuMAP2_04072 HuMAP2_05564 HuMAP2_06424 |
| COL14A1 | HuMAP2_01361 HuMAP2_04072 HuMAP2_05564 HuMAP2_06424 |
| COL12A1 | HuMAP2_01361 HuMAP2_04072 HuMAP2_05564 HuMAP2_06424 |