hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04078

Confidence: Medium High

Genename	Protein Name	Links
RPGR	X-linked retinitis pigmentosa GTPase regulator	UniProt NCBI
PDE6D	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17)	UniProt NCBI
RPGRIP1	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6741	1.00675659188e-05	0.666666666667	RPGR PDE6D	INPP5E-PDE6D-RPGR complex
HP:0000512	0.000320698793087	1.0	RPGR RPGRIP1 PDE6D	Abnormal electroretinogram
HP:0030453	0.000636587763158	1.0	RPGR RPGRIP1 PDE6D	Abnormal visual electrophysiology
HP:0012043	0.00120138848745	0.666666666667	RPGR RPGRIP1	Pendular nystagmus
HP:0000550	0.0015104340107	0.666666666667	RPGRIP1 PDE6D	Undetectable electroretinogram
HP:0000548	0.00243734739233	0.666666666667	RPGR RPGRIP1	Cone/cone-rod dystrophy
HP:0008056	0.00330290006376	1.0	RPGR RPGRIP1 PDE6D	Aplasia/Hypoplasia affecting the eye
HP:0007843	0.00384043859485	0.666666666667	RPGR RPGRIP1	Attenuation of retinal blood vessels
HP:0001746	0.0183346678183	0.666666666667	RPGR RPGRIP1	Asplenia
HP:0000608	0.0183346678183	0.666666666667	RPGR RPGRIP1	Macular degeneration
HP:0010451	0.0189067773604	0.666666666667	RPGR RPGRIP1	Aplasia/Hypoplasia of the spleen
HP:0100258	0.0194876494112	0.666666666667	RPGRIP1 PDE6D	Preaxial polydactyly
HP:0000551	0.0237990042853	0.666666666667	RPGR RPGRIP1	Color vision defect
HP:0000479	0.0301561740182	1.0	RPGR RPGRIP1 PDE6D	Abnormal retinal morphology
HP:0000035	0.0309699417001	1.0	RPGR RPGRIP1 PDE6D	Abnormal testis morphology
HP:0010938	0.0316591597185	1.0	RPGR RPGRIP1 PDE6D	Abnormality of the external nose
HP:0001162	0.0329433889933	0.666666666667	RPGRIP1 PDE6D	Postaxial hand polydactyly
HP:0000563	0.0337079994886	0.666666666667	RPGR RPGRIP1	Keratoconus
HP:0001696	0.0337079994886	0.666666666667	RPGR RPGRIP1	Situs inversus totalis
HP:0011534	0.0344813463748	0.666666666667	RPGR RPGRIP1	Abnormal spatial orientation of the cardiac segments
HP:0100692	0.0360542445711	0.666666666667	RPGR RPGRIP1	Increased corneal curvature
HP:0100689	0.0384790851177	0.666666666667	RPGR RPGRIP1	Decreased corneal thickness
HP:0002789	0.0393048254184	0.666666666667	RPGR PDE6D	Tachypnea
HP:0011486	0.0393048254184	0.666666666667	RPGR RPGRIP1	Abnormality of corneal thickness
HP:0001829	0.0409824890748	0.666666666667	RPGRIP1 PDE6D	Foot polydactyly
HP:0001651	0.0426950555564	0.666666666667	RPGR RPGRIP1	Dextrocardia
HP:0000639	0.04291596551	1.0	RPGR RPGRIP1 PDE6D	Nystagmus
HP:0004307	0.0435644243888	0.666666666667	RPGR RPGRIP1	Abnormal anatomic location of the heart
HP:0009136	0.044442515366	0.666666666667	RPGRIP1 PDE6D	Duplication involving bones of the feet
HP:0012547	0.0446392984448	1.0	RPGR RPGRIP1 PDE6D	Abnormal involuntary eye movements
CORUM:7242	0.0499776345577	0.333333333333	RPGRIP1	RPGRIP1-SPATA7 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
RPGR	RPGRIP1	0.17	0.427	gupta (RPGRIP1) boldt (RPGRIP1) boldt_WMM
PDE6D	RPGR	0.095	0.359	bioplex (RPGR) bioplex_WMM boldt (RPGR) boldt_WMM

Images

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Complex HuMAP2_04078 has an average edge precision of 0.393 which is ranked 3396 out of all 6965 complexes.

Related Complexes

Genename	Complexes
RPGR	HuMAP2_00333 HuMAP2_00699 HuMAP2_00864 HuMAP2_01782 HuMAP2_04078 HuMAP2_05152
PDE6D	HuMAP2_00333 HuMAP2_00699 HuMAP2_04078
RPGRIP1	HuMAP2_00333 HuMAP2_02817 HuMAP2_02926 HuMAP2_04021 HuMAP2_04078

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04078