hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04080
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) | UniProt NCBI |
| CRIP2 | Cysteine-rich protein 2 (CRP-2) (Protein ESP1) | UniProt NCBI |
| NANS | Sialic acid synthase (N-acetylneuraminate synthase) (EC 2.5.1.56) (N-acetylneuraminate-9-phosphate synthase) (EC 2.5.1.57) (N-acetylneuraminic acid phosphate synthase) (N-acetylneuraminic acid synthase) | UniProt NCBI |
| RAC3 | Ras-related C3 botulinum toxin substrate 3 (p21-Rac3) | UniProt NCBI |
| RAC2 | Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2290 | 1.47866495656e-07 | 0.6 | RAC2 RAC3 RAC1 | RalA downstream regulated genes |
| WP:WP3937 | 2.72386132263e-06 | 0.6 | RAC2 RAC3 RAC1 | Microglia Pathogen Phagocytosis Pathway |
| KEGG:05416 | 1.30729641617e-05 | 0.6 | RAC2 RAC3 RAC1 | Viral myocarditis |
| KEGG:04664 | 2.25729723653e-05 | 0.6 | RAC2 RAC3 RAC1 | Fc epsilon RI signaling pathway |
| KEGG:04370 | 2.25729723653e-05 | 0.6 | RAC2 RAC3 RAC1 | VEGF signaling pathway |
| WP:WP4216 | 3.81869950786e-05 | 0.6 | RAC2 RAC3 RAC1 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:04662 | 4.11682217947e-05 | 0.6 | RAC2 RAC3 RAC1 | B cell receptor signaling pathway |
| KEGG:04520 | 4.50168450517e-05 | 0.6 | RAC2 RAC3 RAC1 | Adherens junction |
| KEGG:05212 | 4.90975651011e-05 | 0.6 | RAC2 RAC3 RAC1 | Pancreatic cancer |
| WP:WP4263 | 6.13140713704e-05 | 0.6 | RAC2 RAC3 RAC1 | Pancreatic adenocarcinoma pathway |
| KEGG:05210 | 7.59906976524e-05 | 0.6 | RAC2 RAC3 RAC1 | Colorectal cancer |
| WP:WP185 | 8.65079697906e-05 | 0.6 | RAC2 RAC3 RAC1 | Integrin-mediated Cell Adhesion |
| KEGG:05231 | 9.73769288451e-05 | 0.6 | RAC2 RAC3 RAC1 | Choline metabolism in cancer |
| WP:WP710 | 0.00012126383097 | 0.6 | RAC2 RAC3 RAC1 | DNA Damage Response (only ATM dependent) |
| KEGG:04650 | 0.000134356221711 | 0.6 | RAC2 RAC3 RAC1 | Natural killer cell mediated cytotoxicity |
| KEGG:04071 | 0.000179646697347 | 0.6 | RAC2 RAC3 RAC1 | Sphingolipid signaling pathway |
| KEGG:05135 | 0.000194978614983 | 0.6 | RAC2 RAC3 RAC1 | Yersinia infection |
| WP:WP51 | 0.00024878117453 | 0.6 | RAC2 RAC3 RAC1 | Regulation of Actin Cytoskeleton |
| KEGG:05418 | 0.000271467766564 | 0.6 | RAC2 RAC3 RAC1 | Fluid shear stress and atherosclerosis |
| KEGG:04062 | 0.000305495250573 | 0.6 | RAC2 RAC3 RAC1 | Chemokine signaling pathway |
| REAC:R-HSA-4086400 | 0.000327410819085 | 0.6 | RAC2 RAC3 RAC1 | PCP/CE pathway |
| WP:WP4223 | 0.000403236542348 | 0.6 | RAC2 RAC3 RAC1 | Ras Signaling |
| KEGG:04310 | 0.000442131169771 | 0.6 | RAC2 RAC3 RAC1 | Wnt signaling pathway |
| KEGG:04360 | 0.000625511303776 | 0.6 | RAC2 RAC3 RAC1 | Axon guidance |
| KEGG:04024 | 0.000684138808884 | 0.6 | RAC2 RAC3 RAC1 | cAMP signaling pathway |
| WP:WP306 | 0.000719570270021 | 0.6 | RAC2 RAC3 RAC1 | Focal Adhesion |
| KEGG:04015 | 0.000721004021602 | 0.6 | RAC2 RAC3 RAC1 | Rap1 signaling pathway |
| KEGG:04014 | 0.000867405343471 | 0.6 | RAC2 RAC3 RAC1 | Ras signaling pathway |
| KEGG:04810 | 0.000910491071115 | 0.6 | RAC2 RAC3 RAC1 | Regulation of actin cytoskeleton |
| KEGG:04510 | 0.000939988213226 | 0.6 | RAC2 RAC3 RAC1 | Focal adhesion |
| REAC:R-HSA-194840 | 0.000982798780442 | 0.6 | RAC2 RAC3 RAC1 | Rho GTPase cycle |
| KEGG:05170 | 0.00109699385517 | 0.6 | RAC2 RAC3 RAC1 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-3858494 | 0.00112457746833 | 0.6 | RAC2 RAC3 RAC1 | Beta-catenin independent WNT signaling |
| WP:WP382 | 0.00113645450729 | 0.6 | RAC2 RAC3 RAC1 | MAPK Signaling Pathway |
| KEGG:05163 | 0.00114726739179 | 0.6 | RAC2 RAC3 RAC1 | Human cytomegalovirus infection |
| REAC:R-HSA-5668599 | 0.00230284247734 | 0.4 | RAC2 RAC1 | RHO GTPases Activate NADPH Oxidases |
| KEGG:04010 | 0.00232977147301 | 0.6 | RAC2 RAC3 RAC1 | MAPK signaling pathway |
| REAC:R-HSA-114604 | 0.00508433997358 | 0.4 | RAC2 RAC1 | GPVI-mediated activation cascade |
| WP:WP4298 | 0.00917640250894 | 0.4 | RAC2 RAC3 | Viral Acute Myocarditis |
| WP:WP23 | 0.0126363339816 | 0.4 | RAC2 RAC1 | B Cell Receptor Signaling Pathway |
| REAC:R-HSA-195721 | 0.0129604262881 | 0.6 | RAC2 RAC3 RAC1 | Signaling by WNT |
| REAC:R-HSA-2219530 | 0.0132857243802 | 0.4 | RAC2 RAC1 | Constitutive Signaling by Aberrant PI3K in Cancer |
| KEGG:05200 | 0.0137388951306 | 0.6 | RAC2 RAC3 RAC1 | Pathways in cancer |
| KEGG:04670 | 0.0162467151192 | 0.4 | RAC2 RAC1 | Leukocyte transendothelial migration |
| KEGG:04666 | 0.0162467151192 | 0.4 | RAC2 RAC1 | Fc gamma R-mediated phagocytosis |
| WP:WP3929 | 0.0250517914711 | 0.4 | RAC2 RAC1 | Chemokine signaling pathway |
| REAC:R-HSA-6811558 | 0.0313816354582 | 0.4 | RAC2 RAC1 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-2219528 | 0.0332320424718 | 0.4 | RAC2 RAC1 | PI3K/AKT Signaling in Cancer |
| REAC:R-HSA-194315 | 0.034259108007 | 0.6 | RAC2 RAC3 RAC1 | Signaling by Rho GTPases |
| REAC:R-HSA-199418 | 0.0380875604325 | 0.4 | RAC2 RAC1 | Negative regulation of the PI3K/AKT network |
| WP:WP481 | 0.0385448371419 | 0.4 | RAC2 RAC1 | Insulin Signaling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAC3 | RAC2 | 0.94 | 0.852 | bioplex (RAC2) bioplex_WMM |
| RAC3 | RAC1 | 0.171 | 0.43 | bioplex (RAC1) bioplex_WMM |
| CRIP2 | RAC1 | 0.11 | 0.379 | fraction |
| RAC1 | NANS | 0.05 | 0.294 | bioplex_WMM fraction |
| RAC3 | NANS | 0.003 | 0.006 | fraction |
| RAC2 | NANS | 0.0 | 0.009 | fraction |
Images
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Complex HuMAP2_04080 has an average edge precision of 0.328 which is ranked 4239 out of all 6965 complexes.
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