hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04081
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AP2A2 | AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) | UniProt NCBI |
| AP2S1 | AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin) | UniProt NCBI |
| EPS15 | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | UniProt NCBI |
| CCDC32 | Coiled-coil domain-containing protein 32 | UniProt NCBI |
| EPS15L1 | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8856825 | 8.87616987911e-07 | 0.8 | EPS15L1 AP2A2 EPS15 AP2S1 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-8856828 | 3.99365490063e-06 | 0.8 | EPS15L1 AP2A2 EPS15 AP2S1 | Clathrin-mediated endocytosis |
| KEGG:04144 | 1.32635921507e-05 | 0.8 | EPS15L1 AP2A2 EPS15 AP2S1 | Endocytosis |
| REAC:R-HSA-182218 | 0.000202356855584 | 0.4 | AP2A2 AP2S1 | Nef Mediated CD8 Down-regulation |
| REAC:R-HSA-9006934 | 0.000402506828977 | 0.8 | EPS15L1 AP2A2 EPS15 AP2S1 | Signaling by Receptor Tyrosine Kinases |
| WP:WP437 | 0.000443577883382 | 0.6 | EPS15L1 EPS15 AP2S1 | EGF/EGFR Signaling Pathway |
| REAC:R-HSA-167590 | 0.000485460775426 | 0.4 | AP2A2 AP2S1 | Nef Mediated CD4 Down-regulation |
| REAC:R-HSA-8866427 | 0.000889652787086 | 0.4 | AP2A2 AP2S1 | VLDLR internalisation and degradation |
| REAC:R-HSA-177504 | 0.00105126658749 | 0.4 | AP2A2 AP2S1 | Retrograde neurotrophin signalling |
| REAC:R-HSA-5140745 | 0.00105126658749 | 0.4 | AP2A2 AP2S1 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
| WP:WP4159 | 0.00116821015313 | 0.4 | AP2A2 AP2S1 | GABA receptor Signaling |
| REAC:R-HSA-5099900 | 0.00122631290825 | 0.4 | AP2A2 AP2S1 | WNT5A-dependent internalization of FZD4 |
| REAC:R-HSA-199991 | 0.00166286547268 | 0.8 | EPS15L1 AP2A2 EPS15 AP2S1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0020580612036 | 0.8 | EPS15L1 AP2A2 EPS15 AP2S1 | Vesicle-mediated transport |
| REAC:R-HSA-164938 | 0.00206071490935 | 0.4 | AP2A2 AP2S1 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| REAC:R-HSA-8964038 | 0.00230284247734 | 0.4 | AP2A2 AP2S1 | LDL clearance |
| WP:WP2267 | 0.00343593293187 | 0.4 | AP2A2 AP2S1 | Synaptic Vesicle Pathway |
| REAC:R-HSA-164952 | 0.00371437175588 | 0.4 | AP2A2 AP2S1 | The role of Nef in HIV-1 replication and disease pathogenesis |
| REAC:R-HSA-182971 | 0.0040368179849 | 0.4 | EPS15L1 EPS15 | EGFR downregulation |
| GO:0005905 | 0.0049400991777 | 0.6 | AP2A2 EPS15 AP2S1 | clathrin-coated pit |
| KEGG:04961 | 0.00522578105965 | 0.4 | AP2A2 AP2S1 | Endocrine and other factor-regulated calcium reabsorption |
| REAC:R-HSA-8964043 | 0.00546022370076 | 0.4 | AP2A2 AP2S1 | Plasma lipoprotein clearance |
| KEGG:04721 | 0.00941045001151 | 0.4 | AP2A2 AP2S1 | Synaptic vesicle cycle |
| REAC:R-HSA-177929 | 0.012121451174 | 0.4 | EPS15L1 EPS15 | Signaling by EGFR |
| REAC:R-HSA-437239 | 0.0132857243802 | 0.4 | AP2A2 AP2S1 | Recycling pathway of L1 |
| REAC:R-HSA-3928665 | 0.0138877528683 | 0.4 | AP2A2 AP2S1 | EPH-ephrin mediated repulsion of cells |
| REAC:R-HSA-5663205 | 0.0198891654246 | 0.6 | AP2A2 EPS15 AP2S1 | Infectious disease |
| REAC:R-HSA-174824 | 0.0206361227401 | 0.4 | AP2A2 AP2S1 | Plasma lipoprotein assembly, remodeling, and clearance |
| REAC:R-HSA-187037 | 0.0351349281697 | 0.4 | AP2A2 AP2S1 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-2682334 | 0.0487798927038 | 0.4 | AP2A2 AP2S1 | EPH-Ephrin signaling |
| CORUM:3231 | 0.0499494897235 | 0.2 | EPS15 | Eps15-stonin2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CCDC32 | AP2S1 | 0.987 | 0.901 | bioplex (AP2S1) bioplex_WMM |
| AP2A2 | AP2S1 | 0.971 | 0.883 | bioplex (AP2S1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| EPS15 | AP2S1 | 0.483 | 0.613 | hein_WMM bioplex (AP2S1) bioplex_WMM youn_WMM gupta_WMM |
| AP2S1 | EPS15L1 | 0.102 | 0.365 | bioplex (AP2S1) bioplex_WMM youn_WMM gupta_WMM |
| EPS15 | EPS15L1 | 0.027 | 0.228 | bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| EPS15 | AP2A2 | 0.012 | 0.147 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CCDC32 | AP2A2 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| EPS15 | CCDC32 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| CCDC32 | EPS15L1 | 0.0 | 0.009 | bioplex_WMM fraction |
| AP2A2 | EPS15L1 | 0.0 | 0.0 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
Click to enlarge
Complex HuMAP2_04081 has an average edge precision of 0.328 which is ranked 4240 out of all 6965 complexes.
Related Complexes