hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04086
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAPGEF5 | Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac) | UniProt NCBI |
| CHL1 | Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | UniProt NCBI |
| ANK2 | Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) | UniProt NCBI |
| ANK1 | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | UniProt NCBI |
| ANK3 | Ankyrin-3 (ANK-3) (Ankyrin-G) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-373760 | 2.17462883355e-06 | 0.8 | ANK2 ANK1 ANK3 CHL1 | L1CAM interactions |
| REAC:R-HSA-445095 | 9.90965664735e-06 | 0.6 | ANK1 ANK3 ANK2 | Interaction between L1 and Ankyrins |
| GO:0043194 | 0.000330213415772 | 0.6 | ANK1 ANK3 ANK2 | axon initial segment |
| REAC:R-HSA-447041 | 0.000377631329325 | 0.4 | CHL1 ANK1 | CHL1 interactions |
| REAC:R-HSA-6807878 | 0.000397120285508 | 0.6 | ANK1 ANK3 ANK2 | COPI-mediated anterograde transport |
| KEGG:05205 | 0.000925161775741 | 0.6 | ANK1 ANK3 ANK2 | Proteoglycans in cancer |
| REAC:R-HSA-422475 | 0.00101311640921 | 0.8 | ANK2 ANK1 ANK3 CHL1 | Axon guidance |
| GO:0030507 | 0.00120569794977 | 0.6 | ANK1 ANK3 ANK2 | spectrin binding |
| REAC:R-HSA-199977 | 0.00130639580421 | 0.6 | ANK1 ANK3 ANK2 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 0.00211299613483 | 0.6 | ANK1 ANK3 ANK2 | Transport to the Golgi and subsequent modification |
| WP:WP4148 | 0.00259148909572 | 0.4 | ANK3 CHL1 | Splicing factor NOVA regulated synaptic proteins |
| GO:0044304 | 0.005924931483 | 0.6 | ANK1 ANK3 ANK2 | main axon |
| REAC:R-HSA-446203 | 0.0100880466408 | 0.6 | ANK1 ANK3 ANK2 | Asparagine N-linked glycosylation |
| REAC:R-HSA-1266738 | 0.0103415798479 | 0.8 | ANK2 ANK1 ANK3 CHL1 | Developmental Biology |
| CORUM:6618 | 0.0499494897235 | 0.2 | ANK3 | RhBG-kAE1-ankyrin-G complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| 114299 | ANK3 | 0.996 | 0.927 | bioplex (114299) bioplex_WMM youn_WMM gupta_WMM |
| ANK3 | RAPGEF5 | 0.602 | 0.67 | bioplex (RAPGEF5) bioplex_WMM |
| 114299 | ANK2 | 0.5 | 0.621 | bioplex (114299) bioplex_WMM |
| RAPGEF5 | ANK1 | 0.254 | 0.478 | bioplex (RAPGEF5) bioplex_WMM |
| RAPGEF5 | ANK2 | 0.091 | 0.355 | bioplex (RAPGEF5) bioplex_WMM |
| ANK3 | CHL1 | 0.047 | 0.29 | bioplex (CHL1) bioplex_WMM |
| ANK2 | CHL1 | 0.03 | 0.236 | bioplex (CHL1) bioplex_WMM |
| ANK1 | CHL1 | 0.027 | 0.225 | bioplex (CHL1) bioplex_WMM |
| ANK3 | ANK2 | 0.012 | 0.15 | bioplex_WMM youn_WMM WMM_only |
| ANK3 | ANK1 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| ANK2 | ANK1 | 0.008 | 0.088 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04086 has an average edge precision of 0.375 which is ranked 3579 out of all 6965 complexes.
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