hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04088
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MZT2B | Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B) | UniProt NCBI |
| MZT2A | Mitotic-spindle organizing protein 2A (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A) | UniProt NCBI |
| TUBGCP6 | Gamma-tubulin complex component 6 (GCP-6) | UniProt NCBI |
| TUBGCP5 | Gamma-tubulin complex component 5 (GCP-5) | UniProt NCBI |
| MZT1 | Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1) | UniProt NCBI |
| TUBGCP4 | Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (Gamma-ring complex protein 76 kDa) (h76p) (hGrip76) | UniProt NCBI |
| TUBG1 | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | UniProt NCBI |
| TUBGCP2 | Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97) | UniProt NCBI |
| TUBGCP3 | Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000930 | 8.47006381065e-23 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | gamma-tubulin complex |
| CORUM:6893 | 2.29174218292e-19 | 0.666666666667 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 | Gamma-tubulin complex |
| REAC:R-HSA-380270 | 4.13501188045e-19 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 4.13501188045e-19 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | Centrosome maturation |
| REAC:R-HSA-380320 | 1.41895005924e-18 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | Recruitment of NuMA to mitotic centrosomes |
| GO:0051415 | 2.77300804133e-16 | 0.666666666667 | TUBGCP6 MZT1 TUBGCP4 TUBGCP2 TUBGCP3 TUBGCP5 | microtubule nucleation by interphase microtubule organizing center |
| REAC:R-HSA-69275 | 1.47395388494e-15 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | G2/M Transition |
| REAC:R-HSA-68877 | 1.54684171442e-15 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | Mitotic Prometaphase |
| REAC:R-HSA-453274 | 1.62291589709e-15 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | Mitotic G2-G2/M phases |
| GO:0051418 | 7.76174055919e-15 | 0.666666666667 | TUBGCP6 MZT1 TUBGCP4 TUBGCP2 TUBGCP3 TUBGCP5 | microtubule nucleation by microtubule organizing center |
| GO:0000931 | 7.76174055919e-15 | 0.666666666667 | TUBGCP6 TUBGCP5 TUBGCP4 MZT2A MZT2B MZT1 | gamma-tubulin large complex |
| GO:0008274 | 7.76174055919e-15 | 0.666666666667 | TUBGCP6 TUBGCP5 TUBGCP4 MZT2A MZT2B MZT1 | gamma-tubulin ring complex |
| GO:0007020 | 2.68034500417e-14 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | microtubule nucleation |
| GO:0044450 | 3.05656940476e-14 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | microtubule organizing center part |
| REAC:R-HSA-68886 | 7.73623936084e-13 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | M Phase |
| GO:0000923 | 1.03218291818e-12 | 0.555555555556 | TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP4 TUBGCP5 | equatorial microtubule organizing center |
| REAC:R-HSA-69278 | 1.33851736087e-11 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | Cell Cycle, Mitotic |
| GO:0046785 | 4.82515283086e-11 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | microtubule polymerization |
| REAC:R-HSA-1640170 | 6.86633268652e-11 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | Cell Cycle |
| GO:0031109 | 6.59063608908e-10 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | microtubule polymerization or depolymerization |
| GO:0051011 | 8.1620840518e-10 | 0.555555555556 | TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP4 TUBGCP5 | microtubule minus-end binding |
| GO:0005813 | 1.05139538287e-09 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | centrosome |
| GO:0043015 | 8.81803084449e-09 | 0.555555555556 | TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP4 TUBGCP5 | gamma-tubulin binding |
| GO:0007051 | 1.20784488778e-08 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | spindle organization |
| GO:0005815 | 1.27926012066e-08 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | microtubule organizing center |
| GO:0051258 | 1.3384785491e-07 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | protein polymerization |
| GO:0051225 | 1.70158852211e-07 | 0.666666666667 | TUBGCP6 MZT1 TUBGCP4 TUBGCP2 TUBGCP3 TUBGCP5 | spindle assembly |
| GO:0015630 | 7.16216154992e-07 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | microtubule cytoskeleton |
| GO:0032155 | 8.70794256443e-07 | 0.555555555556 | TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP4 TUBGCP5 | cell division site part |
| GO:0031122 | 1.11120357488e-06 | 0.555555555556 | TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP4 TUBGCP5 | cytoplasmic microtubule organization |
| GO:0032153 | 1.56847057581e-06 | 0.555555555556 | TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP4 TUBGCP5 | cell division site |
| GO:0051321 | 1.69589077344e-06 | 0.666666666667 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 | meiotic cell cycle |
| GO:0044430 | 6.40285487113e-06 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | cytoskeletal part |
| CORUM:3714 | 4.02261743042e-05 | 0.222222222222 | TUBGCP3 TUBGCP2 | Pericentrin-GCP complex |
| GO:0000226 | 4.30672240942e-05 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | microtubule cytoskeleton organization |
| GO:0005856 | 4.45418003239e-05 | 1.0 | TUBGCP6 TUBGCP5 TUBGCP4 MZT1 MZT2A TUBGCP3 TUBGCP2 TUBG1 MZT2B | cytoskeleton |
| GO:0097435 | 7.72093322317e-05 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | supramolecular fiber organization |
| GO:0007017 | 0.000374994100819 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | microtubule-based process |
| GO:0070925 | 0.000646435441104 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | organelle assembly |
| GO:0008017 | 0.00250489460284 | 0.555555555556 | TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP4 TUBGCP5 | microtubule binding |
| GO:0000278 | 0.00270098013707 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | mitotic cell cycle |
| GO:0034622 | 0.00308161794369 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | cellular protein-containing complex assembly |
| GO:0005819 | 0.00471774972823 | 0.555555555556 | TUBG1 TUBGCP3 MZT1 MZT2B MZT2A | spindle |
| HPA:031020_21 | 0.00574600090365 | 0.777777777778 | TUBGCP6 MZT1 TUBGCP4 MZT2A TUBGCP2 TUBGCP3 MZT2B | ovary; ovarian stroma cells[Approved,Low] |
| GO:0022414 | 0.00836453364237 | 0.666666666667 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 | reproductive process |
| GO:0000003 | 0.00855033520204 | 0.666666666667 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 | reproduction |
| GO:0015631 | 0.0107945845604 | 0.555555555556 | TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP4 TUBGCP5 | tubulin binding |
| GO:0007010 | 0.0118812271427 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | cytoskeleton organization |
| GO:0022402 | 0.0179882470993 | 0.777777777778 | TUBGCP6 TUBGCP5 TUBGCP4 TUBGCP2 TUBGCP3 TUBG1 MZT1 | cell cycle process |
| HP:0007731 | 0.0470553832537 | 0.222222222222 | TUBGCP6 TUBGCP4 | Chorioretinal dysplasia |
| GO:0008275 | 0.0486736709081 | 0.222222222222 | TUBGCP3 TUBGCP2 | gamma-tubulin small complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MZT2B | TUBGCP2 | 1.0 | 0.949 | hein_WMM bioplex (MZT2B) bioplex_WMM boldt hein (TUBGCP2) Malo fraction boldt_WMM |
| TUBGCP2 | TUBGCP3 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (TUBGCP2) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| TUBGCP2 | TUBGCP6 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (TUBGCP2,TUBGCP6) Malo fraction |
| MZT2B | TUBGCP4 | 1.0 | 0.949 | hein_WMM bioplex (MZT2B) bioplex_WMM hein (TUBGCP4) boldt_WMM |
| MZT2B | TUBG1 | 1.0 | 0.949 | hein_WMM bioplex (MZT2B) bioplex_WMM hein (TUBG1) |
| MZT2B | TUBGCP5 | 1.0 | 0.949 | hein_WMM bioplex (MZT2B,TUBGCP5) bioplex_WMM hein (TUBGCP5) |
| TUBG1 | TUBGCP6 | 0.999 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (TUBG1,TUBGCP6) Malo fraction |
| MZT2B | TUBGCP6 | 0.999 | 0.949 | hein_WMM bioplex (MZT2B) bioplex_WMM hein (TUBGCP6) |
| MZT2A | TUBGCP5 | 0.999 | 0.949 | hein_WMM bioplex (TUBGCP5) bioplex_WMM hein (MZT2A,TUBGCP5) |
| TUBGCP6 | TUBGCP5 | 0.999 | 0.949 | hein_WMM bioplex (TUBGCP5) bioplex_WMM hein (TUBGCP5,TUBGCP6) |
| TUBGCP5 | TUBGCP4 | 0.997 | 0.934 | hein_WMM bioplex (TUBGCP5) bioplex_WMM hein (TUBGCP4,TUBGCP5) |
| TUBGCP5 | MZT1 | 0.994 | 0.919 | hein_WMM bioplex (MZT1,TUBGCP5) bioplex_WMM hein (MZT1,TUBGCP5) |
| TUBGCP5 | TUBGCP3 | 0.993 | 0.918 | hein_WMM bioplex (TUBGCP5) bioplex_WMM youn_WMM hein (TUBGCP5) |
| TUBGCP2 | TUBGCP5 | 0.991 | 0.909 | hein_WMM bioplex (TUBGCP5) bioplex_WMM hein (TUBGCP2,TUBGCP5) |
| TUBG1 | TUBGCP5 | 0.989 | 0.905 | hein_WMM bioplex (TUBGCP5) bioplex_WMM youn_WMM hein (TUBG1,TUBGCP5) |
| MZT2A | MZT1 | 0.985 | 0.899 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1,MZT2A) |
| MZT2B | TUBGCP3 | 0.972 | 0.886 | hein_WMM bioplex (MZT2B) bioplex_WMM |
| TUBGCP3 | MZT1 | 0.965 | 0.875 | hein_WMM bioplex (MZT1,TUBGCP3) bioplex_WMM hein (MZT1) |
| TUBGCP6 | MZT1 | 0.924 | 0.843 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1,TUBGCP6) |
| TUBGCP2 | MZT1 | 0.908 | 0.831 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1,TUBGCP2) |
| MZT1 | TUBGCP4 | 0.867 | 0.801 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1,TUBGCP4) |
| MZT2B | MZT1 | 0.83 | 0.777 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1) |
| TUBG1 | TUBGCP4 | 0.824 | 0.773 | hein_WMM bioplex_WMM boldt youn_WMM hein (TUBG1,TUBGCP4) boldt_WMM |
| MZT2A | TUBGCP3 | 0.734 | 0.738 | hein_WMM bioplex_WMM hein (MZT2A) gupta_WMM |
| TUBGCP2 | TUBGCP4 | 0.706 | 0.727 | hein_WMM bioplex_WMM boldt youn_WMM hein (TUBGCP2,TUBGCP4) boldt_WMM |
| TUBGCP2 | MZT2A | 0.657 | 0.696 | hein_WMM bioplex_WMM hein (MZT2A,TUBGCP2) gupta_WMM |
| TUBGCP6 | TUBGCP4 | 0.578 | 0.66 | hein_WMM bioplex_WMM hein (TUBGCP4,TUBGCP6) |
| MZT2A | TUBGCP6 | 0.548 | 0.642 | hein_WMM bioplex_WMM hein (MZT2A,TUBGCP6) |
| TUBG1 | MZT1 | 0.548 | 0.642 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1,TUBG1) |
| TUBGCP2 | TUBG1 | 0.5 | 0.621 | hein_WMM bioplex_WMM boldt youn_WMM hein (TUBG1,TUBGCP2) gupta_WMM boldt_WMM |
| TUBGCP6 | TUBGCP3 | 0.422 | 0.573 | hein_WMM bioplex_WMM hein (TUBGCP6) |
| MZT2B | MZT2A | 0.374 | 0.546 | hein_WMM bioplex_WMM hein (MZT2A) |
| TUBGCP3 | TUBGCP4 | 0.343 | 0.531 | hein_WMM bioplex_WMM hein (TUBGCP4) boldt_WMM |
| MZT2A | TUBGCP4 | 0.275 | 0.487 | hein_WMM bioplex_WMM hein (MZT2A,TUBGCP4) |
| TUBG1 | TUBGCP3 | 0.25 | 0.473 | hein_WMM bioplex_WMM youn_WMM hein (TUBG1) gupta_WMM boldt_WMM |
| TUBG1 | MZT2A | 0.209 | 0.456 | hein_WMM bioplex_WMM hein (MZT2A,TUBG1) |
Images
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Complex HuMAP2_04088 has an average edge precision of 0.793 which is ranked 943 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MZT2B | HuMAP2_02682 HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| MZT2A | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| TUBGCP6 | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| TUBGCP5 | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| MZT1 | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| TUBGCP4 | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| TUBG1 | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| TUBGCP2 | HuMAP2_02682 HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| TUBGCP3 | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |