hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04096
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RBPJ | Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) | UniProt NCBI |
| FBXO42 | F-box only protein 42 (Just one F-box and Kelch domain-containing protein) | UniProt NCBI |
| ZNF589 | Zinc finger protein 589 (Stem cell zinc finger protein 1) | UniProt NCBI |
| MAML1 | Mastermind-like protein 1 (Mam-1) | UniProt NCBI |
| NOTCH1 | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | UniProt NCBI |
| RAB28 | Ras-related protein Rab-28 | UniProt NCBI |
| ZNF268 | Zinc finger protein 268 (Zinc finger protein HZF3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3113 | 3.38154272427e-09 | 0.428571428571 | MAML1 RBPJ NOTCH1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2897 | 3.38154272427e-09 | 0.428571428571 | MAML1 RBPJ NOTCH1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2890 | 3.38154272427e-09 | 0.428571428571 | MAML1 RBPJ NOTCH1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2639 | 9.65174231113e-07 | 0.428571428571 | MAML1 RBPJ NOTCH1 | HES1 promoter-Notch enhancer complex |
| REAC:R-HSA-8941856 | 3.0343270142e-06 | 0.428571428571 | MAML1 RBPJ NOTCH1 | RUNX3 regulates NOTCH signaling |
| GO:0002193 | 3.17865016081e-06 | 0.428571428571 | MAML1 RBPJ NOTCH1 | MAML1-RBP-Jkappa- ICN1 complex |
| REAC:R-HSA-210744 | 3.861092404e-06 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| WP:WP3845 | 6.81533287938e-06 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Canonical and Non-canonical Notch signaling |
| CORUM:2907 | 1.007158685e-05 | 0.285714285714 | RBPJ NOTCH1 | RBP-Jkappa-Notch1 complex |
| REAC:R-HSA-9013695 | 1.02682123619e-05 | 0.428571428571 | MAML1 RBPJ NOTCH1 | NOTCH4 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-9013508 | 1.87516446834e-05 | 0.428571428571 | MAML1 RBPJ NOTCH1 | NOTCH3 Intracellular Domain Regulates Transcription |
| CORUM:2946 | 3.02079974644e-05 | 0.285714285714 | RBPJ NOTCH1 | YY1-Notch1-RBP-Jkappa complex |
| WP:WP268 | 3.06804134301e-05 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Notch Signaling |
| REAC:R-HSA-350054 | 3.0945418259e-05 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Notch-HLH transcription pathway |
| REAC:R-HSA-186712 | 3.86423784685e-05 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Regulation of beta-cell development |
| KEGG:04330 | 5.3549795788e-05 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Notch signaling pathway |
| WP:WP61 | 9.27396722419e-05 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Notch Signaling Pathway |
| REAC:R-HSA-2122947 | 0.000130142457859 | 0.428571428571 | MAML1 RBPJ NOTCH1 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-9012852 | 0.00013963689386 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH3 |
| KEGG:04658 | 0.000187840964122 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Th1 and Th2 cell differentiation |
| REAC:R-HSA-2894862 | 0.00024654158605 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2644602 | 0.00024654158605 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2894858 | 0.00024654158605 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644606 | 0.00024654158605 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2644603 | 0.00024654158605 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH1 in Cancer |
| WP:WP4147 | 0.000362009370683 | 0.285714285714 | RBPJ NOTCH1 | PTF1A related regulatory pathway |
| REAC:R-HSA-1980143 | 0.000437510353479 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH1 |
| REAC:R-HSA-9013694 | 0.000827889523177 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH4 |
| REAC:R-HSA-2197563 | 0.00113808966034 | 0.285714285714 | MAML1 RBPJ | NOTCH2 intracellular domain regulates transcription |
| REAC:R-HSA-1912408 | 0.00126876263254 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-8878159 | 0.00131126474762 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Transcriptional regulation by RUNX3 |
| REAC:R-HSA-1912422 | 0.00206623616174 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Pre-NOTCH Expression and Processing |
| GO:0007221 | 0.00215539204286 | 0.428571428571 | MAML1 RBPJ NOTCH1 | positive regulation of transcription of Notch receptor target |
| REAC:R-HSA-212436 | 0.00498507162086 | 0.714285714286 | ZNF589 ZNF268 NOTCH1 RBPJ MAML1 | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.00848206160772 | 0.714285714286 | ZNF589 ZNF268 NOTCH1 RBPJ MAML1 | RNA Polymerase II Transcription |
| REAC:R-HSA-1980145 | 0.0118992043595 | 0.285714285714 | MAML1 RBPJ | Signaling by NOTCH2 |
| HP:0004050 | 0.0120875188399 | 0.285714285714 | RBPJ NOTCH1 | Absent hand |
| HP:0004935 | 0.0120875188399 | 0.285714285714 | RBPJ NOTCH1 | Pulmonary artery atresia |
| REAC:R-HSA-74160 | 0.0144220896917 | 0.714285714286 | ZNF589 ZNF268 NOTCH1 RBPJ MAML1 | Gene expression (Transcription) |
| MIRNA:hsa-miR-30a-3p | 0.0145420418846 | 0.428571428571 | MAML1 ZNF268 NOTCH1 | hsa-miR-30a-3p |
| HP:0002040 | 0.0156492047667 | 0.285714285714 | RBPJ NOTCH1 | Esophageal varix |
| GO:0045747 | 0.0156741996846 | 0.428571428571 | MAML1 RBPJ NOTCH1 | positive regulation of Notch signaling pathway |
| KEGG:05165 | 0.0156896284271 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Human papillomavirus infection |
| HP:0001362 | 0.017601413367 | 0.285714285714 | RBPJ NOTCH1 | Calvarial skull defect |
| HP:0006970 | 0.017601413367 | 0.285714285714 | RBPJ NOTCH1 | Periventricular leukomalacia |
| REAC:R-HSA-157118 | 0.01781034888 | 0.428571428571 | MAML1 RBPJ NOTCH1 | Signaling by NOTCH |
| WP:WP2840 | 0.0181890182156 | 0.285714285714 | RBPJ NOTCH1 | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) |
| WP:WP2064 | 0.028232060271 | 0.285714285714 | RBPJ NOTCH1 | Neural Crest Differentiation |
| HP:0002132 | 0.0344585130221 | 0.285714285714 | RBPJ NOTCH1 | Porencephalic cyst |
| CORUM:2908 | 0.0499886427319 | 0.142857142857 | RBPJ | RBP-Jkappa-SHARP complex |
| CORUM:2947 | 0.0499886427319 | 0.142857142857 | NOTCH1 | YY1-Notch1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAML1 | RBPJ | 1.0 | 0.949 | hein_WMM bioplex (RBPJ) bioplex_WMM hein (RBPJ) |
| RBPJ | NOTCH1 | 0.863 | 0.799 | hein_WMM bioplex (RBPJ) bioplex_WMM hein (RBPJ) |
| RBPJ | ZNF589 | 0.329 | 0.518 | bioplex (RBPJ) bioplex_WMM |
| RBPJ | FBXO42 | 0.204 | 0.454 | bioplex (FBXO42,RBPJ) bioplex_WMM |
| ZNF268 | RBPJ | 0.095 | 0.359 | bioplex (RBPJ) bioplex_WMM |
| RAB28 | FBXO42 | 0.084 | 0.348 | bioplex (FBXO42) bioplex_WMM |
| MAML1 | NOTCH1 | 0.01 | 0.136 | hein_WMM bioplex_WMM WMM_only |
| MAML1 | FBXO42 | 0.009 | 0.102 | bioplex_WMM WMM_only |
| ZNF268 | MAML1 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| MAML1 | ZNF589 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| ZNF268 | FBXO42 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| FBXO42 | NOTCH1 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| ZNF589 | FBXO42 | 0.008 | 0.089 | bioplex_WMM WMM_only |
| ZNF268 | NOTCH1 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| ZNF268 | ZNF589 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| ZNF589 | NOTCH1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| RBPJ | RAB28 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| MAML1 | RAB28 | 0.007 | 0.002 | youn_WMM WMM_only |
Images
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Complex HuMAP2_04096 has an average edge precision of 0.249 which is ranked 5402 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RBPJ | HuMAP2_01320 HuMAP2_01458 HuMAP2_04096 HuMAP2_04608 HuMAP2_05094 HuMAP2_06455 |
| FBXO42 | HuMAP2_04096 HuMAP2_05437 HuMAP2_06455 |
| ZNF589 | HuMAP2_01320 HuMAP2_04096 HuMAP2_04608 HuMAP2_06455 |
| MAML1 | HuMAP2_01320 HuMAP2_01458 HuMAP2_04096 HuMAP2_04608 HuMAP2_05094 HuMAP2_06455 |
| NOTCH1 | HuMAP2_04096 HuMAP2_04608 HuMAP2_05094 HuMAP2_06455 |
| RAB28 | HuMAP2_04096 HuMAP2_05437 HuMAP2_06455 |
| ZNF268 | HuMAP2_01320 HuMAP2_04096 HuMAP2_04608 HuMAP2_06455 |