hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04098

Confidence: Medium

Genename	Protein Name	Links
KIFC1	Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET)	UniProt NCBI
KPNA2	Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)	UniProt NCBI
NUP50	Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)	UniProt NCBI
KPNA1	Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]	UniProt NCBI
RNGTT	mRNA-capping enzyme (HCAP1) (HCE) [Includes: Polynucleotide 5'-triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)]	UniProt NCBI
KPNA6	Importin subunit alpha-7 (Karyopherin subunit alpha-6)	UniProt NCBI
RNMT	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7)-)-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p)	UniProt NCBI
KPNA5	Importin subunit alpha-6 (Karyopherin subunit alpha-5)	UniProt NCBI
NUP153	Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153)	UniProt NCBI
CDCA2	Cell division cycle-associated protein 2 (Recruits PP1 onto mitotic chromatin at anaphase protein) (Repo-Man)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-168276	3.73146980164e-09	0.5	KPNA5 NUP153 NUP50 KPNA1 KPNA2	NS1 Mediated Effects on Host Pathways
REAC:R-HSA-168253	4.29563963818e-09	0.5	KPNA5 NUP153 NUP50 KPNA1 KPNA2	Host Interactions with Influenza Factors
GO:0008139	5.41048579313e-08	0.5	KPNA6 KPNA5 NUP153 KPNA1 KPNA2	nuclear localization sequence binding
REAC:R-HSA-1169408	8.19808447123e-08	0.5	KPNA5 NUP153 NUP50 KPNA1 KPNA2	ISG15 antiviral mechanism
REAC:R-HSA-5663205	1.03201009972e-07	0.7	KPNA1 KPNA5 NUP50 KPNA2 RNMT NUP153 RNGTT	Infectious disease
REAC:R-HSA-1169410	1.36473902495e-07	0.5	KPNA5 NUP153 NUP50 KPNA1 KPNA2	Antiviral mechanism by IFN-stimulated genes
GO:0005643	1.61694792199e-07	0.6	KPNA1 KPNA5 NUP50 NUP153 KPNA6 KPNA2	nuclear pore
GO:0006606	7.60306649378e-07	0.6	KPNA1 KPNA5 NUP50 NUP153 KPNA6 KPNA2	protein import into nucleus
GO:0005048	1.17730687265e-06	0.5	KPNA6 KPNA5 NUP153 KPNA1 KPNA2	signal sequence binding
GO:0051170	2.34367273066e-06	0.6	KPNA1 KPNA5 NUP50 NUP153 KPNA6 KPNA2	import into nucleus
REAC:R-HSA-162587	4.2826883577e-06	0.5	NUP153 RNMT KPNA1 RNGTT NUP50	HIV Life Cycle
REAC:R-HSA-168254	4.58591835696e-06	0.5	KPNA5 NUP153 NUP50 KPNA1 KPNA2	Influenza Infection
GO:0075733	6.43954736165e-06	0.5	KPNA6 NUP153 NUP50 KPNA1 KPNA2	intracellular transport of virus
GO:0017038	7.17249122237e-06	0.6	KPNA1 KPNA5 NUP50 NUP153 KPNA6 KPNA2	protein import
GO:0046794	8.51867055317e-06	0.5	KPNA6 NUP153 NUP50 KPNA1 KPNA2	transport of virus
REAC:R-HSA-913531	1.03311302639e-05	0.5	KPNA5 NUP153 NUP50 KPNA1 KPNA2	Interferon Signaling
GO:1902579	2.27878791295e-05	0.5	KPNA6 NUP153 NUP50 KPNA1 KPNA2	multi-organism localization
GO:0044766	2.27878791295e-05	0.5	KPNA6 NUP153 NUP50 KPNA1 KPNA2	multi-organism transport
GO:0006607	2.46935086017e-05	0.4	KPNA6 KPNA5 KPNA1 KPNA2	NLS-bearing protein import into nucleus
GO:0034504	3.52508898744e-05	0.6	KPNA1 KPNA5 NUP50 NUP153 KPNA6 KPNA2	protein localization to nucleus
REAC:R-HSA-162906	3.56847250261e-05	0.5	NUP153 RNMT KPNA1 RNGTT NUP50	HIV Infection
REAC:R-HSA-1643685	8.83839609071e-05	0.7	KPNA1 KPNA5 NUP50 KPNA2 RNMT NUP153 RNGTT	Disease
KEGG:05164	9.02320080688e-05	0.4	KPNA6 KPNA5 KPNA1 KPNA2	Influenza A
REAC:R-HSA-168271	0.000148071668905	0.3	NUP153 KPNA1 NUP50	Transport of Ribonucleoproteins into the Host Nucleus
REAC:R-HSA-180910	0.000183378151501	0.3	NUP153 KPNA1 NUP50	Vpr-mediated nuclear import of PICs
REAC:R-HSA-176033	0.000246170553574	0.3	NUP153 KPNA1 NUP50	Interactions of Vpr with host cellular proteins
REAC:R-HSA-162599	0.00025612319255	0.4	NUP153 RNMT NUP50 RNGTT	Late Phase of HIV Life Cycle
GO:0006913	0.000317321116626	0.6	KPNA1 KPNA5 NUP50 NUP153 KPNA6 KPNA2	nucleocytoplasmic transport
GO:0051169	0.000339214467841	0.6	KPNA1 KPNA5 NUP50 NUP153 KPNA6 KPNA2	nuclear transport
GO:0005635	0.000818845627094	0.6	KPNA1 KPNA5 NUP50 NUP153 KPNA6 KPNA2	nuclear envelope
GO:0019054	0.00395159560419	0.3	KPNA5 KPNA1 KPNA2	modulation by virus of host cellular process
GO:0042277	0.00436646228543	0.5	KPNA6 KPNA5 NUP153 KPNA1 KPNA2	peptide binding
GO:0016032	0.00570218458704	0.6	KPNA1 KPNA5 NUP50 NUP153 KPNA6 KPNA2	viral process
REAC:R-HSA-1280215	0.00912942615379	0.5	KPNA5 NUP153 NUP50 KPNA1 KPNA2	Cytokine Signaling in Immune system
GO:0072594	0.00925015498781	0.6	KPNA1 KPNA5 NUP50 NUP153 KPNA6 KPNA2	establishment of protein localization to organelle
GO:0033218	0.0095246400785	0.5	KPNA6 KPNA5 NUP153 KPNA1 KPNA2	amide binding
GO:0044403	0.0100924136087	0.6	KPNA1 KPNA5 NUP50 NUP153 KPNA6 KPNA2	symbiotic process
GO:0019058	0.0113085018911	0.5	KPNA6 NUP153 NUP50 KPNA1 KPNA2	viral life cycle
REAC:R-HSA-162909	0.0129085319269	0.3	NUP153 KPNA1 NUP50	Host Interactions of HIV factors
GO:0044419	0.0139586345691	0.6	KPNA1 KPNA5 NUP50 NUP153 KPNA6 KPNA2	interspecies interaction between organisms
GO:0044068	0.0144029117203	0.3	KPNA5 KPNA1 KPNA2	modulation by symbiont of host cellular process
REAC:R-HSA-168255	0.0186307081545	0.3	NUP153 KPNA1 NUP50	Influenza Life Cycle
GO:0075732	0.020287053512	0.2	KPNA6 KPNA2	viral penetration into host nucleus
GO:0099527	0.020287053512	0.2	KPNA1 KPNA2	postsynapse to nucleus signaling pathway
GO:1902594	0.020287053512	0.2	KPNA6 KPNA2	multi-organism nuclear import
GO:0075506	0.020287053512	0.2	KPNA6 KPNA2	entry of viral genome into host nucleus through nuclear pore complex via importin
GO:0019048	0.0248721634083	0.3	KPNA5 KPNA1 KPNA2	modulation by virus of host morphology or physiology
REAC:R-HSA-167160	0.0295283272229	0.2	RNMT RNGTT	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
REAC:R-HSA-77075	0.0295283272229	0.2	RNMT RNGTT	RNA Pol II CTD phosphorylation and interaction with CE
REAC:R-HSA-170822	0.0317883468809	0.2	NUP153 NUP50	Regulation of Glucokinase by Glucokinase Regulatory Protein
REAC:R-HSA-168333	0.0317883468809	0.2	NUP153 NUP50	NEP/NS2 Interacts with the Cellular Export Machinery
REAC:R-HSA-5619107	0.0317883468809	0.2	NUP153 NUP50	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
REAC:R-HSA-168274	0.0317883468809	0.2	NUP153 NUP50	Export of Viral Ribonucleoproteins from Nucleus
REAC:R-HSA-72086	0.0341308097173	0.2	RNMT RNGTT	mRNA Capping
REAC:R-HSA-159227	0.0365556262578	0.2	NUP153 NUP50	Transport of the SLBP independent Mature mRNA
REAC:R-HSA-180746	0.0365556262578	0.2	NUP153 NUP50	Nuclear import of Rev protein
REAC:R-HSA-165054	0.0390627070912	0.2	NUP153 NUP50	Rev-mediated nuclear export of HIV RNA
REAC:R-HSA-4085377	0.0390627070912	0.2	NUP153 NUP50	SUMOylation of SUMOylation proteins
REAC:R-HSA-159230	0.0390627070912	0.2	NUP153 NUP50	Transport of the SLBP Dependant Mature mRNA
REAC:R-HSA-3301854	0.04165196287	0.2	NUP153 NUP50	Nuclear Pore Complex (NPC) Disassembly
REAC:R-HSA-177243	0.0443233043097	0.2	NUP153 NUP50	Interactions of Rev with host cellular proteins
REAC:R-HSA-3232142	0.0470766421894	0.2	NUP153 NUP50	SUMOylation of ubiquitinylation proteins

Edges

Protein 1	Protein 2	Score	Precision	Evidence
NUP50	NUP153	1.0	0.949	hein_WMM bioplex (NUP50) bioplex_WMM Guru boldt youn_WMM hein (NUP153) gupta_WMM fraction boldt_WMM
NUP50	KIFC1	1.0	0.949	hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM hein (KIFC1) gupta_WMM
NUP50	RNGTT	0.986	0.901	youn (RNGTT) bioplex (NUP50,RNGTT) bioplex_WMM boldt youn_WMM boldt_WMM
KPNA1	NUP50	0.894	0.82	hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM hein (KPNA1) gupta_WMM treiber_WMM
KPNA2	NUP153	0.661	0.698	hein_WMM bioplex (KPNA2) bioplex_WMM Guru youn_WMM hein (NUP153) gupta_WMM fraction
NUP50	CDCA2	0.155	0.416	hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM gupta_WMM
NUP50	KPNA5	0.118	0.391	bioplex (NUP50) bioplex_WMM youn_WMM gupta_WMM
KPNA6	NUP50	0.111	0.381	hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM gupta_WMM
NUP153	CDCA2	0.098	0.357	hein_WMM bioplex_WMM youn_WMM hein (NUP153) gupta_WMM
KPNA1	RNMT	0.06	0.335	hein_WMM bioplex (RNMT) bioplex_WMM youn_WMM hein (KPNA1)
KPNA2	CDCA2	0.054	0.298	hein_WMM bioplex (KPNA2) bioplex_WMM youn_WMM gupta_WMM
KPNA6	KPNA1	0.05	0.296	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM
KPNA6	KPNA2	0.044	0.28	hein_WMM bioplex (KPNA2) bioplex_WMM youn_WMM gupta_WMM fraction
KPNA2	NUP50	0.037	0.265	hein_WMM bioplex (KPNA2,NUP50) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
KPNA6	RNMT	0.033	0.252	bioplex (RNMT) bioplex_WMM youn_WMM
KPNA2	KPNA5	0.028	0.231	bioplex (KPNA2) bioplex_WMM youn_WMM gupta_WMM fraction
NUP153	KIFC1	0.024	0.21	hein_WMM bioplex_WMM youn_WMM hein (KIFC1,NUP153) gupta_WMM
KPNA5	RNMT	0.023	0.21	bioplex (RNMT) bioplex_WMM youn_WMM
KPNA6	KPNA5	0.012	0.146	bioplex_WMM youn_WMM gupta_WMM WMM_only
KPNA1	KPNA5	0.012	0.144	bioplex_WMM youn_WMM gupta_WMM WMM_only
CDCA2	KIFC1	0.009	0.108	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
NUP50	RNMT	0.009	0.106	hein_WMM bioplex (NUP50,RNMT) bioplex_WMM youn_WMM
CDCA2	KPNA5	0.009	0.1	bioplex_WMM youn_WMM WMM_only
CDCA2	RNGTT	0.008	0.088	bioplex_WMM youn_WMM WMM_only
KPNA6	RNGTT	0.008	0.083	youn (RNGTT) bioplex_WMM youn_WMM
KPNA1	CDCA2	0.008	0.086	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
KPNA1	KIFC1	0.008	0.065	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
RNGTT	RNMT	0.008	0.06	youn (RNGTT) bioplex_WMM youn_WMM
NUP153	RNGTT	0.008	0.041	youn (RNGTT) bioplex_WMM boldt youn_WMM boldt_WMM
KPNA1	KPNA2	0.008	0.041	hein_WMM bioplex (KPNA2) bioplex_WMM youn_WMM gupta_WMM fraction
KPNA2	KIFC1	0.008	0.025	hein_WMM bioplex_WMM youn_WMM hein (KIFC1) gupta_WMM
KPNA6	CDCA2	0.008	0.024	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
KIFC1	KPNA5	0.008	0.027	bioplex_WMM youn_WMM WMM_only
KIFC1	RNMT	0.008	0.024	bioplex_WMM youn_WMM WMM_only
KPNA1	RNGTT	0.007	0.007	bioplex_WMM youn_WMM WMM_only
NUP153	KPNA5	0.007	0.008	bioplex_WMM youn_WMM gupta_WMM WMM_only
KPNA6	KIFC1	0.007	0.01	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
KPNA2	RNGTT	0.007	0.007	youn (RNGTT) bioplex (RNGTT) bioplex_WMM boldt youn_WMM boldt_WMM
CDCA2	RNMT	0.007	0.006	bioplex_WMM youn_WMM WMM_only
NUP153	RNMT	0.006	0.009	bioplex (RNMT) bioplex_WMM youn_WMM
RNGTT	KPNA5	0.006	0.004	youn (RNGTT) bioplex_WMM youn_WMM
KPNA2	RNMT	0.003	0.02	bioplex (KPNA2,RNMT) bioplex_WMM youn_WMM fraction treiber_WMM
RNGTT	KIFC1	0.003	0.007	youn (RNGTT) bioplex_WMM youn_WMM fraction
KPNA6	NUP153	0.003	0.014	hein_WMM bioplex_WMM youn_WMM hein (NUP153) gupta_WMM
KPNA1	NUP153	0.0	0.009	hein_WMM bioplex_WMM youn_WMM hein (NUP153) gupta_WMM

Images

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Complex HuMAP2_04098 has an average edge precision of 0.211 which is ranked 6002 out of all 6965 complexes.

Related Complexes

Genename	Complexes
KIFC1	HuMAP2_01473 HuMAP2_03236 HuMAP2_04098 HuMAP2_06117 HuMAP2_06218 HuMAP2_06750 HuMAP2_06806
KPNA2	HuMAP2_01285 HuMAP2_01705 HuMAP2_04098 HuMAP2_04747 HuMAP2_06354
NUP50	HuMAP2_01285 HuMAP2_01473 HuMAP2_03236 HuMAP2_04098 HuMAP2_05429 HuMAP2_06117 HuMAP2_06218
KPNA1	HuMAP2_01285 HuMAP2_01473 HuMAP2_04098 HuMAP2_04630 HuMAP2_05768 HuMAP2_06117 HuMAP2_06137 HuMAP2_06218
RNGTT	HuMAP2_01473 HuMAP2_03236 HuMAP2_04098 HuMAP2_05762 HuMAP2_06117 HuMAP2_06218
KPNA6	HuMAP2_00200 HuMAP2_01285 HuMAP2_02561 HuMAP2_04098 HuMAP2_04630 HuMAP2_06137 HuMAP2_06218
RNMT	HuMAP2_04098 HuMAP2_04630 HuMAP2_05584 HuMAP2_05768 HuMAP2_06137 HuMAP2_06218
KPNA5	HuMAP2_03236 HuMAP2_04098 HuMAP2_04630 HuMAP2_06137 HuMAP2_06218
NUP153	HuMAP2_01285 HuMAP2_01473 HuMAP2_01705 HuMAP2_03834 HuMAP2_04098 HuMAP2_04845 HuMAP2_05429
CDCA2	HuMAP2_01285 HuMAP2_03834 HuMAP2_04098

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04098