hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04107
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PCBD1 | Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD) | UniProt NCBI |
| IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) | UniProt NCBI |
| IDH3G | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) | UniProt NCBI |
| IDH3B | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta) | UniProt NCBI |
| GCNT4 | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 (EC 2.4.1.102) (Core 2-branching enzyme 3) (Core2-GlcNAc-transferase 3) (C2GnT3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6949 | 1.35146690511e-09 | 0.6 | IDH3A IDH3G IDH3B | Isocitrate dehydrogenase [NAD], mitochondrial |
| WP:WP78 | 4.56811629309e-07 | 0.6 | IDH3A IDH3G IDH3B | TCA Cycle (aka Krebs or citric acid cycle) |
| KEGG:01210 | 5.87329237683e-07 | 0.6 | IDH3A IDH3G IDH3B | 2-Oxocarboxylic acid metabolism |
| GO:0004449 | 9.08185760231e-07 | 0.6 | IDH3A IDH3G IDH3B | isocitrate dehydrogenase (NAD+) activity |
| KEGG:00020 | 3.15221459068e-06 | 0.6 | IDH3A IDH3G IDH3B | Citrate cycle (TCA cycle) |
| REAC:R-HSA-71403 | 3.60987410111e-06 | 0.6 | IDH3A IDH3G IDH3B | Citric acid cycle (TCA cycle) |
| GO:0004448 | 9.08002798436e-06 | 0.6 | IDH3A IDH3G IDH3B | isocitrate dehydrogenase activity |
| GO:0006102 | 9.08002798436e-06 | 0.6 | IDH3A IDH3G IDH3B | isocitrate metabolic process |
| KEGG:01230 | 4.90975651011e-05 | 0.6 | IDH3A IDH3G IDH3B | Biosynthesis of amino acids |
| REAC:R-HSA-71406 | 5.97963045475e-05 | 0.6 | IDH3A IDH3G IDH3B | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0072350 | 0.000199619769136 | 0.6 | IDH3A IDH3G IDH3B | tricarboxylic acid metabolic process |
| KEGG:01200 | 0.000205667969449 | 0.6 | IDH3A IDH3G IDH3B | Carbon metabolism |
| KEGG:01100 | 0.000225140891789 | 1.0 | GCNT4 IDH3A PCBD1 IDH3G IDH3B | Metabolic pathways |
| REAC:R-HSA-1428517 | 0.00196642775139 | 0.6 | IDH3A IDH3G IDH3B | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0006099 | 0.00367721278555 | 0.6 | IDH3A IDH3G IDH3B | tricarboxylic acid cycle |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IDH3G | IDH3A | 0.999 | 0.948 | bioplex (IDH3A,IDH3G) bioplex_WMM Guru fraction |
| IDH3G | IDH3B | 0.975 | 0.887 | bioplex (IDH3B,IDH3G) bioplex_WMM Guru gupta_WMM fraction |
| IDH3A | IDH3B | 0.97 | 0.881 | bioplex (IDH3A,IDH3B) bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| IDH3G | GCNT4 | 0.046 | 0.293 | fraction |
| PCBD1 | GCNT4 | 0.024 | 0.212 | fraction |
| PCBD1 | IDH3B | 0.006 | 0.006 | bioplex (IDH3B) |
| IDH3G | PCBD1 | 0.0 | 0.0 | fraction |
| PCBD1 | IDH3A | 0.0 | 0.001 | bioplex (IDH3A) bioplex_WMM fraction |
Images
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Complex HuMAP2_04107 has an average edge precision of 0.403 which is ranked 3282 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PCBD1 | HuMAP2_00850 HuMAP2_04107 HuMAP2_04122 HuMAP2_05398 |
| IDH3A | HuMAP2_04107 HuMAP2_05860 HuMAP2_06816 |
| IDH3G | HuMAP2_00244 HuMAP2_04107 HuMAP2_05860 HuMAP2_06816 |
| IDH3B | HuMAP2_04107 HuMAP2_06816 |
| GCNT4 | HuMAP2_03817 HuMAP2_04107 HuMAP2_04122 HuMAP2_06812 |