hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04134

Confidence: Medium

Genename	Protein Name	Links
LAGE3	EKC/KEOPS complex subunit LAGE3 (L antigen family member 3) (Protein ESO-3) (Protein ITBA2)	UniProt NCBI
TPRKB	EKC/KEOPS complex subunit TPRKB (PRPK-binding protein) (TP53RK-binding protein)	UniProt NCBI
TP53RK	EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase)	UniProt NCBI
HYKK	Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1)	UniProt NCBI
GON7	EKC/KEOPS complex subunit GON7	UniProt NCBI
OSGEP	Probable tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP)	UniProt NCBI
GSPT2	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (G1 to S phase transition protein 2 homolog)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:7555	9.08345369489e-13	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	KEOPS complex
GO:0000408	1.03206737618e-12	0.714285714286	TP53RK OSGEP GON7 LAGE3 TPRKB	EKC/KEOPS complex
HP:0100720	7.4343134924e-09	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Hypoplasia of the ear cartilage
HP:0002410	2.47304270892e-08	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Aqueductal stenosis
HP:0002036	1.31275802191e-07	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Hiatus hernia
REAC:R-HSA-6782315	2.87472269464e-07	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	tRNA modification in the nucleus and cytosol
HP:0005108	4.24100764231e-07	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormality of the intervertebral disk
GO:0070525	6.09613706377e-07	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	tRNA threonylcarbamoyladenosine metabolic process
HP:0000096	2.58248165527e-06	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Glomerulosclerosis
HP:0003774	6.98075896938e-06	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Stage 5 chronic kidney disease
HP:0001181	7.42992914349e-06	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Adducted thumb
REAC:R-HSA-72306	1.19447245275e-05	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	tRNA processing
HP:0000601	1.39261651577e-05	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Hypotelorism
HP:0012622	1.62676889866e-05	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Chronic kidney disease
HP:0000112	2.28690126279e-05	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Nephropathy
HP:0000100	5.48728234166e-05	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Nephrotic syndrome
HP:0001622	5.48728234166e-05	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Premature birth
HP:0001302	6.12927937871e-05	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Pachygyria
HP:0031263	9.89588293271e-05	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormal renal corpuscle morphology
HP:0000095	9.89588293271e-05	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormality of renal glomerulus morphology
HP:0001339	0.000112344064406	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Lissencephaly
HP:0000093	0.000138967150573	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Proteinuria
HP:0020129	0.00017487398816	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormal urine protein level
HP:0011035	0.000189980237885	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormal renal cortex morphology
CORUM:7556	0.000211266711219	0.285714285714	OSGEP LAGE3	PRAME complex
HP:0100490	0.00024744531333	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Camptodactyly of finger
HP:0001220	0.000260339428441	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Interphalangeal joint contracture of finger
HP:0000400	0.000287625750635	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Macrotia
HP:0006261	0.000309450427701	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormal phalangeal joint morphology of the hand
HP:0012575	0.000332488349248	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormal nephron morphology
HP:0004374	0.000348542500542	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Hemiplegia/hemiparesis
HP:0012785	0.000356783138647	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Flexion contracture of finger
REAC:R-HSA-8953854	0.000516765920428	0.714285714286	TP53RK OSGEP TPRKB LAGE3 GSPT2	Metabolism of RNA
HP:0009473	0.000639554492976	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Joint contracture of the hand
HP:0012385	0.000989970856888	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Camptodactyly
HP:0100360	0.00106309267056	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Contractures of the joints of the upper limbs
HP:0030044	0.0013067210095	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Flexion contracture of digit
HP:0002536	0.00180216100326	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormal cortical gyration
HP:0001172	0.00185842383723	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormal thumb morphology
HP:0000083	0.00267758979755	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Renal insufficiency
HP:0003121	0.00283008573423	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Limb joint contracture
HP:0002538	0.00302968224917	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormality of the cerebral cortex
HP:0002269	0.00473427655754	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormality of neuronal migration
HP:0002353	0.0063990668966	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	EEG abnormality
HP:0010549	0.0068379729891	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Weakness due to upper motor neuron dysfunction
HP:0001967	0.00760297450628	0.285714285714	OSGEP TP53RK	Diffuse mesangial sclerosis
HP:0030178	0.00770018443158	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormality of central nervous system electrophysiology
HP:0009810	0.00778237757503	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormality of upper limb joint
HP:0100790	0.00891119114176	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Hernia
HP:0001511	0.0090950639533	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Intrauterine growth retardation
GO:0002949	0.00946729163895	0.285714285714	OSGEP TPRKB	tRNA threonylcarbamoyladenosine modification
HP:0001966	0.0120875188399	0.285714285714	OSGEP TP53RK	Mesangial abnormality
HP:0002577	0.0127908609105	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormality of the stomach
HP:0001311	0.0157598562109	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormal nervous system electrophysiology
HPA:050020_22	0.0162796850885	0.714285714286	TP53RK GSPT2 GON7 LAGE3 TPRKB	spleen; cells in white pulp[Approved,Medium]
HP:0003110	0.0207026447632	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormality of urine homeostasis
HP:0005918	0.0262990920596	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormal finger phalanx morphology
HP:0100543	0.0262990920596	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Cognitive impairment
HP:0012211	0.026503020773	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormal renal physiology
HP:0000377	0.0288241536589	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormality of the pinna
HP:0000316	0.0292617861774	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Hypertelorism
HP:0012444	0.0324640689024	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Brain atrophy
HP:0100807	0.0328706615374	0.428571428571	OSGEP LAGE3 TP53RK	Long fingers
HP:0000347	0.0334246943108	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Micrognathia
HP:0001371	0.0339127989086	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Flexion contracture
HP:0009118	0.0341588148118	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Aplasia/Hypoplasia of the mandible
HP:0009116	0.0364326744694	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Aplasia/Hypoplasia involving bones of the skull
HP:0100261	0.037743166612	0.571428571429	OSGEP TPRKB LAGE3 TP53RK	Abnormal tendon morphology
HPA:015010_23	0.0426115752027	0.571428571429	TP53RK GON7 LAGE3 TPRKB	epididymis; glandular cells[Approved,High]

Edges

Protein 1	Protein 2	Score	Precision	Evidence
LAGE3	OSGEP	1.0	0.949	hein_WMM bioplex (OSGEP) bioplex_WMM boldt hein (OSGEP) fraction boldt_WMM
TP53RK	OSGEP	1.0	0.949	hein_WMM bioplex (OSGEP,TP53RK) bioplex_WMM boldt youn_WMM hein (OSGEP) boldt_WMM
TPRKB	OSGEP	1.0	0.949	hein_WMM bioplex (OSGEP) bioplex_WMM boldt hein (OSGEP) boldt_WMM
GON7	OSGEP	1.0	0.949	hein_WMM bioplex (OSGEP) bioplex_WMM hein (OSGEP)
TP53RK	GON7	0.878	0.812	hein_WMM bioplex (TP53RK) bioplex_WMM
TP53RK	TPRKB	0.87	0.803	hein_WMM bioplex (TP53RK) bioplex_WMM boldt boldt_WMM
TP53RK	LAGE3	0.55	0.643	hein_WMM bioplex (TP53RK) bioplex_WMM boldt boldt_WMM
LAGE3	GSPT2	0.028	0.231	gupta_WMM fraction
OSGEP	HYKK	0.025	0.212	bioplex (OSGEP) bioplex_WMM
LAGE3	TPRKB	0.021	0.188	hein_WMM bioplex_WMM boldt boldt_WMM
TPRKB	GON7	0.013	0.149	hein_WMM bioplex_WMM WMM_only
LAGE3	GON7	0.011	0.14	hein_WMM bioplex_WMM WMM_only
GON7	HYKK	0.009	0.108	bioplex_WMM WMM_only
TPRKB	HYKK	0.008	0.092	bioplex_WMM WMM_only
LAGE3	HYKK	0.008	0.066	bioplex_WMM WMM_only
OSGEP	GSPT2	0.008	0.059	fraction
TP53RK	HYKK	0.007	0.005	bioplex_WMM WMM_only
TPRKB	GSPT2	0.0	0.009	fraction

Images

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Complex HuMAP2_04134 has an average edge precision of 0.406 which is ranked 3250 out of all 6965 complexes.

Related Complexes

Genename	Complexes
LAGE3	HuMAP2_01144 HuMAP2_01706 HuMAP2_02664 HuMAP2_03463 HuMAP2_04134 HuMAP2_04445 HuMAP2_05672
TPRKB	HuMAP2_01144 HuMAP2_01706 HuMAP2_03463 HuMAP2_04134
TP53RK	HuMAP2_01144 HuMAP2_01706 HuMAP2_03463 HuMAP2_04134
HYKK	HuMAP2_01706 HuMAP2_03463 HuMAP2_04134
GON7	HuMAP2_01144 HuMAP2_01706 HuMAP2_03463 HuMAP2_04134
OSGEP	HuMAP2_01144 HuMAP2_01706 HuMAP2_02664 HuMAP2_03463 HuMAP2_04134
GSPT2	HuMAP2_01706 HuMAP2_03606 HuMAP2_04134 HuMAP2_04153 HuMAP2_06250 HuMAP2_06475

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04134