hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04134
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LAGE3 | EKC/KEOPS complex subunit LAGE3 (L antigen family member 3) (Protein ESO-3) (Protein ITBA2) | UniProt NCBI |
| TPRKB | EKC/KEOPS complex subunit TPRKB (PRPK-binding protein) (TP53RK-binding protein) | UniProt NCBI |
| TP53RK | EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase) | UniProt NCBI |
| HYKK | Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1) | UniProt NCBI |
| GON7 | EKC/KEOPS complex subunit GON7 | UniProt NCBI |
| OSGEP | Probable tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP) | UniProt NCBI |
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (G1 to S phase transition protein 2 homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7555 | 9.08345369489e-13 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | KEOPS complex |
| GO:0000408 | 1.03206737618e-12 | 0.714285714286 | TP53RK OSGEP LAGE3 GON7 TPRKB | EKC/KEOPS complex |
| HP:0100720 | 7.4343134924e-09 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Hypoplasia of the ear cartilage |
| HP:0002410 | 2.47304270892e-08 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Aqueductal stenosis |
| HP:0002036 | 1.31275802191e-07 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Hiatus hernia |
| REAC:R-HSA-6782315 | 2.87472269464e-07 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | tRNA modification in the nucleus and cytosol |
| HP:0005108 | 4.24100764231e-07 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormality of the intervertebral disk |
| GO:0070525 | 6.09613706377e-07 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | tRNA threonylcarbamoyladenosine metabolic process |
| HP:0000096 | 2.58248165527e-06 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Glomerulosclerosis |
| HP:0003774 | 6.98075896938e-06 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Stage 5 chronic kidney disease |
| HP:0001181 | 7.42992914349e-06 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Adducted thumb |
| REAC:R-HSA-72306 | 1.19447245275e-05 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | tRNA processing |
| HP:0000601 | 1.39261651577e-05 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Hypotelorism |
| HP:0012622 | 1.62676889866e-05 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Chronic kidney disease |
| HP:0000112 | 2.28690126279e-05 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Nephropathy |
| HP:0000100 | 5.48728234166e-05 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Nephrotic syndrome |
| HP:0001622 | 5.48728234166e-05 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Premature birth |
| HP:0001302 | 6.12927937871e-05 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Pachygyria |
| HP:0031263 | 9.89588293271e-05 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormal renal corpuscle morphology |
| HP:0000095 | 9.89588293271e-05 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormality of renal glomerulus morphology |
| HP:0001339 | 0.000112344064406 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Lissencephaly |
| HP:0000093 | 0.000138967150573 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Proteinuria |
| HP:0020129 | 0.00017487398816 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormal urine protein level |
| HP:0011035 | 0.000189980237885 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormal renal cortex morphology |
| CORUM:7556 | 0.000211266711219 | 0.285714285714 | OSGEP LAGE3 | PRAME complex |
| HP:0100490 | 0.00024744531333 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Camptodactyly of finger |
| HP:0001220 | 0.000260339428441 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Interphalangeal joint contracture of finger |
| HP:0000400 | 0.000287625750635 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Macrotia |
| HP:0006261 | 0.000309450427701 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormal phalangeal joint morphology of the hand |
| HP:0012575 | 0.000332488349248 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormal nephron morphology |
| HP:0004374 | 0.000348542500542 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Hemiplegia/hemiparesis |
| HP:0012785 | 0.000356783138647 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Flexion contracture of finger |
| REAC:R-HSA-8953854 | 0.000516765920428 | 0.714285714286 | TP53RK OSGEP GSPT2 LAGE3 TPRKB | Metabolism of RNA |
| HP:0009473 | 0.000639554492976 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Joint contracture of the hand |
| HP:0012385 | 0.000989970856888 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Camptodactyly |
| HP:0100360 | 0.00106309267056 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Contractures of the joints of the upper limbs |
| HP:0030044 | 0.0013067210095 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Flexion contracture of digit |
| HP:0002536 | 0.00180216100326 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormal cortical gyration |
| HP:0001172 | 0.00185842383723 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormal thumb morphology |
| HP:0000083 | 0.00267758979755 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Renal insufficiency |
| HP:0003121 | 0.00283008573423 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Limb joint contracture |
| HP:0002538 | 0.00302968224917 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormality of the cerebral cortex |
| HP:0002269 | 0.00473427655754 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormality of neuronal migration |
| HP:0002353 | 0.0063990668966 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | EEG abnormality |
| HP:0010549 | 0.0068379729891 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Weakness due to upper motor neuron dysfunction |
| HP:0001967 | 0.00760297450628 | 0.285714285714 | OSGEP TP53RK | Diffuse mesangial sclerosis |
| HP:0030178 | 0.00770018443158 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormality of central nervous system electrophysiology |
| HP:0009810 | 0.00778237757503 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormality of upper limb joint |
| HP:0100790 | 0.00891119114176 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Hernia |
| HP:0001511 | 0.0090950639533 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Intrauterine growth retardation |
| GO:0002949 | 0.00946729163895 | 0.285714285714 | OSGEP TPRKB | tRNA threonylcarbamoyladenosine modification |
| HP:0001966 | 0.0120875188399 | 0.285714285714 | OSGEP TP53RK | Mesangial abnormality |
| HP:0002577 | 0.0127908609105 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormality of the stomach |
| HP:0001311 | 0.0157598562109 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormal nervous system electrophysiology |
| HPA:050020_22 | 0.0162796850885 | 0.714285714286 | TP53RK TPRKB LAGE3 GON7 GSPT2 | spleen; cells in white pulp[Approved,Medium] |
| HP:0003110 | 0.0207026447632 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormality of urine homeostasis |
| HP:0005918 | 0.0262990920596 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormal finger phalanx morphology |
| HP:0100543 | 0.0262990920596 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Cognitive impairment |
| HP:0012211 | 0.026503020773 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormal renal physiology |
| HP:0000377 | 0.0288241536589 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormality of the pinna |
| HP:0000316 | 0.0292617861774 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Hypertelorism |
| HP:0012444 | 0.0324640689024 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Brain atrophy |
| HP:0100807 | 0.0328706615374 | 0.428571428571 | OSGEP LAGE3 TP53RK | Long fingers |
| HP:0000347 | 0.0334246943108 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Micrognathia |
| HP:0001371 | 0.0339127989086 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Flexion contracture |
| HP:0009118 | 0.0341588148118 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Aplasia/Hypoplasia of the mandible |
| HP:0009116 | 0.0364326744694 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Aplasia/Hypoplasia involving bones of the skull |
| HP:0100261 | 0.037743166612 | 0.571428571429 | TP53RK OSGEP LAGE3 TPRKB | Abnormal tendon morphology |
| HPA:015010_23 | 0.0426115752027 | 0.571428571429 | TPRKB LAGE3 GON7 TP53RK | epididymis; glandular cells[Approved,High] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LAGE3 | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP) bioplex_WMM boldt hein (OSGEP) fraction boldt_WMM |
| TP53RK | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP,TP53RK) bioplex_WMM boldt youn_WMM hein (OSGEP) boldt_WMM |
| TPRKB | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP) bioplex_WMM boldt hein (OSGEP) boldt_WMM |
| GON7 | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP) bioplex_WMM hein (OSGEP) |
| TP53RK | GON7 | 0.878 | 0.812 | hein_WMM bioplex (TP53RK) bioplex_WMM |
| TP53RK | TPRKB | 0.87 | 0.803 | hein_WMM bioplex (TP53RK) bioplex_WMM boldt boldt_WMM |
| TP53RK | LAGE3 | 0.55 | 0.643 | hein_WMM bioplex (TP53RK) bioplex_WMM boldt boldt_WMM |
| LAGE3 | GSPT2 | 0.028 | 0.231 | gupta_WMM fraction |
| OSGEP | HYKK | 0.025 | 0.212 | bioplex (OSGEP) bioplex_WMM |
| LAGE3 | TPRKB | 0.021 | 0.188 | hein_WMM bioplex_WMM boldt boldt_WMM |
| TPRKB | GON7 | 0.013 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| LAGE3 | GON7 | 0.011 | 0.14 | hein_WMM bioplex_WMM WMM_only |
| GON7 | HYKK | 0.009 | 0.108 | bioplex_WMM WMM_only |
| TPRKB | HYKK | 0.008 | 0.092 | bioplex_WMM WMM_only |
| LAGE3 | HYKK | 0.008 | 0.066 | bioplex_WMM WMM_only |
| OSGEP | GSPT2 | 0.008 | 0.059 | fraction |
| TP53RK | HYKK | 0.007 | 0.005 | bioplex_WMM WMM_only |
| TPRKB | GSPT2 | 0.0 | 0.009 | fraction |
Images
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Complex HuMAP2_04134 has an average edge precision of 0.406 which is ranked 3250 out of all 6965 complexes.
Related Complexes