hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04136
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ESS2 | Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2) | UniProt NCBI |
| CRNKL1 | Crooked neck-like protein 1 (Crooked neck homolog) (hCrn) | UniProt NCBI |
| PPIL1 | Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase PPIL1) | UniProt NCBI |
| CWC15 | Spliceosome-associated protein CWC15 homolog | UniProt NCBI |
| RBM22 | Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16) | UniProt NCBI |
| SNW1 | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1181 | 1.0520080621e-12 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | C complex spliceosome |
| CORUM:351 | 3.84254950184e-11 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | Spliceosome |
| GO:0071013 | 1.24602854355e-09 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | catalytic step 2 spliceosome |
| GO:0071007 | 6.9945924325e-09 | 0.833333333333 | CWC15 RBM22 SNW1 CRNKL1 PPIL1 | U2-type catalytic step 2 spliceosome |
| KEGG:03040 | 1.29360168582e-08 | 0.833333333333 | CWC15 RBM22 SNW1 CRNKL1 PPIL1 | Spliceosome |
| GO:0005681 | 7.26714234825e-08 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | spliceosomal complex |
| REAC:R-HSA-72163 | 2.24555583894e-07 | 0.833333333333 | CWC15 RBM22 SNW1 CRNKL1 PPIL1 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 2.80323298201e-07 | 0.833333333333 | CWC15 RBM22 SNW1 CRNKL1 PPIL1 | mRNA Splicing |
| REAC:R-HSA-72203 | 9.10267227481e-07 | 0.833333333333 | CWC15 RBM22 SNW1 CRNKL1 PPIL1 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0005684 | 2.27476470409e-06 | 0.833333333333 | CWC15 RBM22 SNW1 CRNKL1 PPIL1 | U2-type spliceosomal complex |
| GO:0000377 | 4.02961537367e-06 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 4.02961537367e-06 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | mRNA splicing, via spliceosome |
| GO:0000375 | 4.26973147328e-06 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | RNA splicing, via transesterification reactions |
| GO:0008380 | 1.12941946802e-05 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | RNA splicing |
| GO:0006397 | 1.75466405335e-05 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | mRNA processing |
| REAC:R-HSA-8953854 | 0.000150175559311 | 0.833333333333 | CWC15 RBM22 SNW1 CRNKL1 PPIL1 | Metabolism of RNA |
| GO:0016071 | 0.000589815677807 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | mRNA metabolic process |
| GO:1990904 | 0.00081928834971 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | ribonucleoprotein complex |
| GO:0006396 | 0.000951885417861 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | RNA processing |
| CORUM:0000000 | 0.0090785708022 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | CORUM root |
| MIRNA:hsa-miR-3923 | 0.0108717421524 | 0.333333333333 | RBM22 CRNKL1 | hsa-miR-3923 |
| GO:1902494 | 0.013185208462 | 1.0 | RBM22 CWC15 SNW1 PPIL1 ESS2 CRNKL1 | catalytic complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PPIL1 | SNW1 | 1.0 | 0.949 | hein_WMM bioplex (PPIL1) bioplex_WMM Guru youn_WMM hein (SNW1) Malo gupta_WMM fraction boldt_WMM |
| SNW1 | CRNKL1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (SNW1) gupta_WMM fraction treiber_WMM |
| SNW1 | CWC15 | 0.946 | 0.857 | hein_WMM bioplex_WMM youn_WMM hein (SNW1) gupta_WMM |
| CRNKL1 | CWC15 | 0.887 | 0.818 | hein_WMM bioplex_WMM youn_WMM hein (CRNKL1) gupta_WMM |
| SNW1 | ESS2 | 0.775 | 0.752 | hein_WMM bioplex_WMM boldt youn_WMM hein (SNW1) gupta_WMM boldt_WMM |
| SNW1 | RBM22 | 0.742 | 0.739 | hein_WMM bioplex_WMM youn_WMM hein (SNW1) treiber_WMM |
| CRNKL1 | RBM22 | 0.022 | 0.199 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CRNKL1 | ESS2 | 0.015 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| RBM22 | ESS2 | 0.013 | 0.151 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| PPIL1 | ESS2 | 0.011 | 0.149 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| PPIL1 | CRNKL1 | 0.01 | 0.129 | hein_WMM bioplex (PPIL1) bioplex_WMM youn_WMM gupta_WMM |
| CWC15 | ESS2 | 0.009 | 0.103 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PPIL1 | RBM22 | 0.009 | 0.101 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| PPIL1 | CWC15 | 0.009 | 0.09 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CWC15 | RBM22 | 0.007 | 0.004 | hein_WMM bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_04136 has an average edge precision of 0.409 which is ranked 3213 out of all 6965 complexes.
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