hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04147
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UQCR10 | Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein) | UniProt NCBI |
| CYC1 | Cytochrome c1, heme protein, mitochondrial (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1) | UniProt NCBI |
| UQCRH | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04260 | 2.11408804451e-06 | 1.0 | UQCR10 CYC1 UQCRH | Cardiac muscle contraction |
| KEGG:00190 | 8.02679835688e-06 | 1.0 | UQCR10 CYC1 UQCRH | Oxidative phosphorylation |
| KEGG:05012 | 9.78855844223e-06 | 1.0 | UQCR10 CYC1 UQCRH | Parkinson disease |
| KEGG:04932 | 1.15269222189e-05 | 1.0 | UQCR10 CYC1 UQCRH | Non-alcoholic fatty liver disease (NAFLD) |
| GO:0005750 | 1.49850650438e-05 | 1.0 | UQCR10 CYC1 UQCRH | mitochondrial respiratory chain complex III |
| GO:0045275 | 1.49850650438e-05 | 1.0 | UQCR10 CYC1 UQCRH | respiratory chain complex III |
| GO:0006122 | 1.49850650438e-05 | 1.0 | UQCR10 CYC1 UQCRH | mitochondrial electron transport, ubiquinol to cytochrome c |
| KEGG:05010 | 1.79503216233e-05 | 1.0 | UQCR10 CYC1 UQCRH | Alzheimer disease |
| KEGG:05016 | 2.6860646392e-05 | 1.0 | UQCR10 CYC1 UQCRH | Huntington disease |
| WP:WP4396 | 2.70021017308e-05 | 1.0 | UQCR10 CYC1 UQCRH | Nonalcoholic fatty liver disease |
| KEGG:04714 | 4.51020686166e-05 | 1.0 | UQCR10 CYC1 UQCRH | Thermogenesis |
| REAC:R-HSA-611105 | 6.02657683388e-05 | 1.0 | UQCR10 CYC1 UQCRH | Respiratory electron transport |
| REAC:R-HSA-163200 | 0.000113954833063 | 1.0 | UQCR10 CYC1 UQCRH | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| GO:0070069 | 0.000160839698137 | 1.0 | UQCR10 CYC1 UQCRH | cytochrome complex |
| REAC:R-HSA-1428517 | 0.000330512177188 | 1.0 | UQCR10 CYC1 UQCRH | The citric acid (TCA) cycle and respiratory electron transport |
| WP:WP111 | 0.00408673569856 | 0.666666666667 | UQCRH UQCR10 | Electron Transport Chain (OXPHOS system in mitochondria) |
| GO:0098803 | 0.00455146375597 | 1.0 | UQCR10 CYC1 UQCRH | respiratory chain complex |
| GO:0005746 | 0.00475834847216 | 1.0 | UQCR10 CYC1 UQCRH | mitochondrial respirasome |
| GO:0070469 | 0.00564855215433 | 1.0 | UQCR10 CYC1 UQCRH | respirasome |
| GO:0042775 | 0.00690911398953 | 1.0 | UQCR10 CYC1 UQCRH | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 0.00718184217333 | 1.0 | UQCR10 CYC1 UQCRH | ATP synthesis coupled electron transport |
| GO:0009055 | 0.00718184217333 | 1.0 | UQCR10 CYC1 UQCRH | electron transfer activity |
| GO:1990204 | 0.00996606725847 | 1.0 | UQCR10 CYC1 UQCRH | oxidoreductase complex |
| KEGG:01100 | 0.0105851300972 | 1.0 | UQCR10 CYC1 UQCRH | Metabolic pathways |
| GO:0022904 | 0.0110330947082 | 1.0 | UQCR10 CYC1 UQCRH | respiratory electron transport chain |
| GO:0022900 | 0.011404996777 | 1.0 | UQCR10 CYC1 UQCRH | electron transport chain |
| GO:0098800 | 0.0218385980648 | 1.0 | UQCR10 CYC1 UQCRH | inner mitochondrial membrane protein complex |
| GO:0006119 | 0.0248678516681 | 1.0 | UQCR10 CYC1 UQCRH | oxidative phosphorylation |
| GO:0016681 | 0.0283955176165 | 0.666666666667 | UQCRH UQCR10 | oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor |
| GO:0016679 | 0.0283955176165 | 0.666666666667 | UQCRH UQCR10 | oxidoreductase activity, acting on diphenols and related substances as donors |
| GO:0008121 | 0.0283955176165 | 0.666666666667 | UQCRH UQCR10 | ubiquinol-cytochrome-c reductase activity |
| GO:0045333 | 0.0442598881134 | 1.0 | UQCR10 CYC1 UQCRH | cellular respiration |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CYC1 | UQCRH | 0.937 | 0.85 | bioplex (CYC1,UQCRH) bioplex_WMM boldt fraction boldt_WMM |
| CYC1 | UQCR10 | 0.266 | 0.482 | bioplex (CYC1) bioplex_WMM boldt boldt_WMM |
| UQCRH | UQCR10 | 0.048 | 0.296 | bioplex (UQCRH) bioplex_WMM boldt boldt_WMM |
Images
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Complex HuMAP2_04147 has an average edge precision of 0.543 which is ranked 2251 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UQCR10 | HuMAP2_04147 HuMAP2_05043 |
| CYC1 | HuMAP2_04006 HuMAP2_04147 HuMAP2_05043 |
| UQCRH | HuMAP2_04006 HuMAP2_04147 HuMAP2_05043 |