hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04152
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MYH14 | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | UniProt NCBI |
| MYL6B | Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B) | UniProt NCBI |
| MYH10 | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | UniProt NCBI |
| IQGAP3 | Ras GTPase-activating-like protein IQGAP3 | UniProt NCBI |
| MYL6 | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04530 | 2.03672600773e-06 | 0.8 | MYH10 MYL6B MYL6 MYH14 | Tight junction |
| REAC:R-HSA-416572 | 2.63058148282e-06 | 0.6 | MYH10 MYL6 MYH14 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5625900 | 2.63058148282e-06 | 0.6 | MYH10 MYL6 MYH14 | RHO GTPases activate CIT |
| REAC:R-HSA-5627117 | 2.63058148282e-06 | 0.6 | MYH10 MYL6 MYH14 | RHO GTPases Activate ROCKs |
| REAC:R-HSA-5627123 | 3.09448976434e-06 | 0.6 | MYH10 MYL6 MYH14 | RHO GTPases activate PAKs |
| REAC:R-HSA-400685 | 4.80586315819e-06 | 0.6 | MYH10 MYL6 MYH14 | Sema4D in semaphorin signaling |
| GO:0016459 | 4.983554895e-06 | 0.8 | MYH10 MYL6B MYL6 MYH14 | myosin complex |
| REAC:R-HSA-3928663 | 7.0533398358e-06 | 0.6 | MYH10 MYL6 MYH14 | EPHA-mediated growth cone collapse |
| GO:0030898 | 7.62415024416e-05 | 0.6 | MYH10 MYL6 MYH14 | actin-dependent ATPase activity |
| REAC:R-HSA-373755 | 8.78979375366e-05 | 0.6 | MYH10 MYL6 MYH14 | Semaphorin interactions |
| REAC:R-HSA-195258 | 0.00013381858755 | 0.8 | MYH10 MYL6 MYH14 IQGAP3 | RHO GTPase Effectors |
| REAC:R-HSA-2682334 | 0.000275953181812 | 0.6 | MYH10 MYL6 MYH14 | EPH-Ephrin signaling |
| REAC:R-HSA-5625740 | 0.000349657961729 | 0.6 | MYH10 MYL6 MYH14 | RHO GTPases activate PKNs |
| REAC:R-HSA-194315 | 0.000501262158212 | 0.8 | MYH10 MYL6 MYH14 IQGAP3 | Signaling by Rho GTPases |
| KEGG:04810 | 0.000910491071115 | 0.6 | MYH10 MYH14 IQGAP3 | Regulation of actin cytoskeleton |
| WP:WP4352 | 0.00103118990123 | 0.6 | IQGAP3 MYL6B MYL6 | Ciliary landscape |
| GO:0016460 | 0.00139593056214 | 0.6 | MYH10 MYL6B MYH14 | myosin II complex |
| REAC:R-HSA-445355 | 0.00709716303977 | 0.4 | MYL6 MYL6B | Smooth Muscle Contraction |
| GO:0097513 | 0.0135228859698 | 0.4 | MYH10 MYH14 | myosin II filament |
| GO:0007519 | 0.0166549756635 | 0.6 | MYH14 MYL6B MYL6 | skeletal muscle tissue development |
| GO:0060538 | 0.0199719657189 | 0.6 | MYH14 MYL6B MYL6 | skeletal muscle organ development |
| KEGG:04270 | 0.0205580217111 | 0.4 | MYL6 MYL6B | Vascular smooth muscle contraction |
| KEGG:04921 | 0.0381461453689 | 0.4 | MYL6 MYL6B | Oxytocin signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MYL6 | MYL6B | 0.26 | 0.482 | hein_WMM bioplex (MYL6) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| MYL6 | MYH10 | 0.12 | 0.392 | hein_WMM bioplex (MYL6) bioplex_WMM boldt youn_WMM hein (MYH10) gupta_WMM boldt_WMM treiber_WMM |
| MYH14 | MYL6 | 0.071 | 0.353 | bioplex (MYL6) bioplex_WMM gupta_WMM boldt_WMM treiber_WMM |
| IQGAP3 | MYL6 | 0.044 | 0.281 | bioplex (MYL6) bioplex_WMM boldt youn_WMM boldt_WMM |
| MYH14 | MYL6B | 0.008 | 0.083 | bioplex_WMM gupta_WMM WMM_only |
| MYL6B | MYH10 | 0.007 | 0.009 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| MYH14 | MYH10 | 0.007 | 0.001 | bioplex_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM |
| MYH14 | IQGAP3 | 0.007 | 0.003 | bioplex_WMM WMM_only treiber_WMM |
| IQGAP3 | MYL6B | 0.006 | 0.004 | bioplex_WMM boldt boldt_WMM |
| IQGAP3 | MYH10 | 0.006 | 0.001 | hein_WMM bioplex_WMM WMM_only boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_04152 has an average edge precision of 0.161 which is ranked 6620 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MYH14 | HuMAP2_01307 HuMAP2_02178 HuMAP2_04152 |
| MYL6B | HuMAP2_02178 HuMAP2_04152 |
| MYH10 | HuMAP2_02178 HuMAP2_03239 HuMAP2_03956 HuMAP2_04152 |
| IQGAP3 | HuMAP2_01307 HuMAP2_02178 HuMAP2_04152 |
| MYL6 | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04152 HuMAP2_04655 |