hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04153
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ETF1 | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | UniProt NCBI |
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (G1 to S phase transition protein 2 homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 0.000456412131355 | 1.0 | ETF1 GSPT2 | Translation Factors |
| KEGG:03015 | 0.000558495798951 | 1.0 | ETF1 GSPT2 | mRNA surveillance pathway |
| GO:0018444 | 0.00135247023414 | 1.0 | ETF1 GSPT2 | translation release factor complex |
| GO:0002184 | 0.00135247023414 | 1.0 | ETF1 GSPT2 | cytoplasmic translational termination |
| GO:0003747 | 0.00676235117068 | 1.0 | ETF1 GSPT2 | translation release factor activity |
| GO:0008079 | 0.00676235117068 | 1.0 | ETF1 GSPT2 | translation termination factor activity |
| REAC:R-HSA-72764 | 0.0070154156135 | 1.0 | ETF1 GSPT2 | Eukaryotic Translation Termination |
| REAC:R-HSA-975956 | 0.00732546145404 | 1.0 | ETF1 GSPT2 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| REAC:R-HSA-975957 | 0.0106052436699 | 1.0 | ETF1 GSPT2 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.0106052436699 | 1.0 | ETF1 GSPT2 | Nonsense-Mediated Decay (NMD) |
| REAC:R-HSA-9010553 | 0.0235098543302 | 1.0 | ETF1 GSPT2 | Regulation of expression of SLITs and ROBOs |
| REAC:R-HSA-376176 | 0.0378389999335 | 1.0 | ETF1 GSPT2 | Signaling by ROBO receptors |
| CORUM:809 | 0.0499173803268 | 0.5 | ETF1 | eRF1-eRF3-GTP-Mg(2+) complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GSPT2 | ETF1 | 0.783 | 0.756 | youn (ETF1) bioplex (GSPT2) bioplex_WMM youn_WMM gupta_WMM |
Images
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Complex HuMAP2_04153 has an average edge precision of 0.756 which is ranked 1109 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ETF1 | HuMAP2_03606 HuMAP2_03670 HuMAP2_04153 HuMAP2_06250 HuMAP2_06475 |
| GSPT2 | HuMAP2_01706 HuMAP2_03606 HuMAP2_04134 HuMAP2_04153 HuMAP2_06250 HuMAP2_06475 |