hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04155

Confidence: Medium

Genename	Protein Name	Links
GGNBP2	Gametogenetin-binding protein 2 (Laryngeal carcinoma-related protein 1) (Protein ZNF403)	UniProt NCBI
FBLN5	Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50)	UniProt NCBI
FBN1	Fibrillin-1 [Cleaved into: Asprosin]	UniProt NCBI
AGRN	Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]	UniProt NCBI
SORL1	Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)	UniProt NCBI
FBLN1	Fibulin-1 (FIBL-1)	UniProt NCBI
LDLR	Low-density lipoprotein receptor (LDL receptor)	UniProt NCBI
PYGB	Glycogen phosphorylase, brain form (EC 2.4.1.1)	UniProt NCBI
FBN2	Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide]	UniProt NCBI
ZFP41	Zinc finger protein 41 homolog (Zfp-41)	UniProt NCBI
LRP2	Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-2129379	9.58230703722e-07	0.363636363636	FBN1 FBLN5 FBN2 FBLN1	Molecules associated with elastic fibres
REAC:R-HSA-1566948	2.3032194964e-06	0.363636363636	FBN1 FBLN5 FBN2 FBLN1	Elastic fibre formation
CORUM:6914	3.35524866385e-05	0.181818181818	FBN1 FBLN5	ELN-FBLN5-FBN1 complex
REAC:R-HSA-1474244	0.000165444451831	0.454545454545	FBN1 FBLN1 FBLN5 AGRN FBN2	Extracellular matrix organization
HP:0001653	0.000267471969347	0.363636363636	FBN1 FBLN5 LDLR FBN2	Mitral regurgitation
HP:0031481	0.000466026017933	0.363636363636	FBN1 FBLN5 LDLR FBN2	Abnormal mitral valve physiology
GO:0044420	0.000525134045179	0.363636363636	FBN1 FBLN5 FBN2 FBLN1	extracellular matrix component
REAC:R-HSA-975634	0.000689964514024	0.272727272727	LRP2 LDLR AGRN	Retinoid metabolism and transport
HP:0031650	0.000784928357889	0.363636363636	FBN1 FBLN5 LDLR FBN2	Abnormal atrioventricular valve physiology
REAC:R-HSA-6806667	0.000856176098851	0.272727272727	LRP2 LDLR AGRN	Metabolism of fat-soluble vitamins
GO:0005201	0.000960656884277	0.454545454545	FBN1 FBLN1 FBLN5 AGRN FBN2	extracellular matrix structural constituent
HP:0009901	0.00109346901099	0.181818181818	FBN1 FBN2	Crumpled ear
GO:0030023	0.00125570522129	0.272727272727	FBN1 FBN2 FBLN5	extracellular matrix constituent conferring elasticity
GO:0097493	0.0024645761864	0.272727272727	FBN1 FBN2 FBLN5	structural molecule activity conferring elasticity
HP:0012727	0.00423813281351	0.272727272727	FBN1 FBN2 FBLN5	Thoracic aortic aneurysm
REAC:R-HSA-2187338	0.00431096631005	0.272727272727	LRP2 LDLR AGRN	Visual phototransduction
HP:0001650	0.00566139280495	0.272727272727	FBN1 LDLR FBLN5	Aortic valve stenosis
GO:0090101	0.0072002593108	0.363636363636	FBN1 LRP2 FBN2 SORL1	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
HP:0001679	0.0073970795898	0.363636363636	FBN1 FBLN5 LDLR FBN2	Abnormal aortic morphology
WP:WP3668	0.00997288187198	0.181818181818	FBN1 FBN2	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease
HP:0031653	0.0109305777668	0.363636363636	FBN1 FBLN5 LDLR FBN2	Abnormal heart valve physiology
GO:0090288	0.0190368176779	0.363636363636	FBN1 LRP2 FBN2 SORL1	negative regulation of cellular response to growth factor stimulus
KEGG:04979	0.0198407652021	0.181818181818	LDLR LRP2	Cholesterol metabolism
HP:0001166	0.0210575189774	0.272727272727	FBN1 FBN2 FBLN5	Arachnodactyly
HP:0004942	0.0225796240014	0.272727272727	FBN1 FBN2 FBLN5	Aortic aneurysm
GO:0030514	0.0263254502884	0.272727272727	FBN1 LRP2 SORL1	negative regulation of BMP signaling pathway
WP:WP1533	0.028426760492	0.181818181818	LDLR LRP2	Vitamin B12 Metabolism
HP:0001238	0.031281838374	0.272727272727	FBN1 FBN2 FBLN5	Slender finger
HP:0011506	0.0330218557658	0.181818181818	FBN2 FBLN5	Choroidal neovascularization
HP:0031652	0.037431015888	0.272727272727	FBN1 LDLR FBLN5	Abnormal aortic valve physiology
HP:0004381	0.0380867898977	0.181818181818	LDLR FBLN5	Supravalvular aortic stenosis
HP:0001832	0.0407825952602	0.272727272727	FBN1 FBN2 FBLN1	Abnormal metatarsal morphology
HP:0002094	0.0434146140095	0.363636363636	FBN1 FBLN5 LDLR AGRN	Dyspnea
HP:0004970	0.043510222531	0.181818181818	FBN1 FBLN5	Ascending tubular aorta aneurysm
HP:0011004	0.0472715327682	0.363636363636	FBN1 FBLN5 LDLR FBN2	Abnormal systemic arterial morphology
HP:0000098	0.0493556829653	0.272727272727	FBN1 FBN2 FBLN5	Tall stature
REAC:R-HSA-196854	0.0494223822243	0.272727272727	LRP2 LDLR AGRN	Metabolism of vitamins and cofactors

Edges

Protein 1	Protein 2	Score	Precision	Evidence
ZFP41	FBLN1	0.712	0.728	bioplex (ZFP41) bioplex_WMM
GGNBP2	ZFP41	0.609	0.674	bioplex (ZFP41) bioplex_WMM
LDLR	ZFP41	0.578	0.66	bioplex (ZFP41) bioplex_WMM
ZFP41	FBN2	0.163	0.42	bioplex (ZFP41) bioplex_WMM
PYGB	ZFP41	0.134	0.406	bioplex (ZFP41) bioplex_WMM
ZFP41	FBN1	0.11	0.378	bioplex (ZFP41) bioplex_WMM
ZFP41	SORL1	0.08	0.35	bioplex (ZFP41) bioplex_WMM
ZFP41	FBLN5	0.056	0.313	bioplex (ZFP41) bioplex_WMM
ZFP41	LRP2	0.054	0.299	bioplex (ZFP41) bioplex_WMM
ZFP41	AGRN	0.023	0.211	bioplex (ZFP41) bioplex_WMM
FBN1	FBLN5	0.013	0.151	bioplex_WMM WMM_only
GGNBP2	FBN1	0.01	0.104	bioplex_WMM WMM_only
GGNBP2	FBLN5	0.009	0.109	bioplex_WMM WMM_only
LDLR	FBN1	0.009	0.108	bioplex_WMM WMM_only
FBLN1	FBN1	0.009	0.099	bioplex_WMM WMM_only
LDLR	FBLN5	0.008	0.094	bioplex_WMM WMM_only
FBN1	AGRN	0.008	0.084	bioplex_WMM WMM_only
FBN1	FBN2	0.008	0.081	bioplex_WMM WMM_only
GGNBP2	AGRN	0.008	0.086	bioplex_WMM WMM_only
FBN1	SORL1	0.008	0.081	bioplex_WMM WMM_only
AGRN	FBLN5	0.008	0.082	bioplex_WMM WMM_only
FBLN1	FBLN5	0.008	0.051	bioplex_WMM WMM_only
FBN2	FBLN5	0.008	0.044	bioplex_WMM WMM_only
SORL1	FBLN5	0.008	0.025	bioplex_WMM WMM_only
GGNBP2	SORL1	0.008	0.024	bioplex_WMM WMM_only
LDLR	AGRN	0.008	0.014	bioplex_WMM WMM_only
GGNBP2	LDLR	0.008	0.008	bioplex_WMM WMM_only
AGRN	SORL1	0.008	0.01	bioplex_WMM WMM_only
PYGB	FBN1	0.007	0.008	bioplex_WMM WMM_only
PYGB	AGRN	0.007	0.008	bioplex_WMM WMM_only
PYGB	GGNBP2	0.007	0.012	bioplex_WMM WMM_only
GGNBP2	FBLN1	0.007	0.012	bioplex_WMM WMM_only
LDLR	FBLN1	0.007	0.009	bioplex_WMM WMM_only
PYGB	FBLN5	0.007	0.012	bioplex_WMM WMM_only
LDLR	SORL1	0.007	0.003	bioplex_WMM WMM_only
FBN1	LRP2	0.007	0.005	bioplex_WMM WMM_only
FBLN1	AGRN	0.007	0.003	bioplex_WMM WMM_only
AGRN	FBN2	0.007	0.002	bioplex_WMM WMM_only
GGNBP2	LRP2	0.007	0.002	bioplex_WMM WMM_only
AGRN	LRP2	0.007	0.006	bioplex_WMM WMM_only
GGNBP2	FBN2	0.007	0.008	bioplex_WMM WMM_only
PYGB	LDLR	0.007	0.005	bioplex_WMM WMM_only
LRP2	FBLN5	0.007	0.003	bioplex_WMM WMM_only
PYGB	SORL1	0.006	0.006	bioplex_WMM WMM_only
PYGB	FBLN1	0.006	0.003	bioplex_WMM WMM_only
PYGB	LRP2	0.006	0.001	bioplex_WMM gupta_WMM WMM_only
PYGB	FBN2	0.006	0.004	bioplex_WMM WMM_only
LDLR	LRP2	0.006	0.008	bioplex_WMM WMM_only
LDLR	FBN2	0.006	0.004	bioplex_WMM WMM_only
FBLN1	SORL1	0.005	0.012	bioplex_WMM WMM_only
SORL1	LRP2	0.005	0.011	bioplex_WMM WMM_only
FBN2	SORL1	0.004	0.011	bioplex_WMM WMM_only
FBLN1	LRP2	0.004	0.013	bioplex_WMM WMM_only
FBLN1	FBN2	0.003	0.014	bioplex_WMM WMM_only
FBN2	LRP2	0.0	0.016	bioplex_WMM WMM_only

Images

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Complex HuMAP2_04155 has an average edge precision of 0.107 which is ranked 6918 out of all 6965 complexes.

Related Complexes

Genename	Complexes
GGNBP2	HuMAP2_01082 HuMAP2_02673 HuMAP2_04155 HuMAP2_05261
FBLN5	HuMAP2_04155 HuMAP2_05834
FBN1	HuMAP2_04155 HuMAP2_05834
AGRN	HuMAP2_04155
SORL1	HuMAP2_04155 HuMAP2_06369
FBLN1	HuMAP2_02647 HuMAP2_02673 HuMAP2_04155
LDLR	HuMAP2_01127 HuMAP2_02673 HuMAP2_04155
PYGB	HuMAP2_00893 HuMAP2_04155 HuMAP2_04576 HuMAP2_06400
FBN2	HuMAP2_04155 HuMAP2_04961
ZFP41	HuMAP2_02647 HuMAP2_02673 HuMAP2_04155
LRP2	HuMAP2_04155

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04155