hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04160
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GET4 | Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) | UniProt NCBI |
| UBL4A | Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) | UniProt NCBI |
| MINDY1 | Ubiquitin carboxyl-terminal hydrolase MINDY-1 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-1) (Protein FAM63A) | UniProt NCBI |
| ASNA1 | ATPase ASNA1 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Transmembrane domain recognition complex 40 kDa ATPase subunit) (hARSA-I) (hASNA-I) | UniProt NCBI |
| BAG6 | Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe) | UniProt NCBI |
| WRB | Tail-anchored protein insertion receptor WRB (Congenital heart disease 5 protein) (Tryptophan-rich basic protein) (WRB) | UniProt NCBI |
| RNF126 | E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0071816 | 1.03206737618e-12 | 0.714285714286 | WRB ASNA1 UBL4A BAG6 GET4 | tail-anchored membrane protein insertion into ER membrane |
| REAC:R-HSA-9609523 | 3.5555021893e-12 | 0.714285714286 | WRB ASNA1 UBL4A BAG6 GET4 | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane |
| GO:0045048 | 3.61183144291e-12 | 0.714285714286 | WRB ASNA1 UBL4A BAG6 GET4 | protein insertion into ER membrane |
| CORUM:6862 | 3.38154272427e-09 | 0.428571428571 | GET4 UBL4A BAG6 | Bag6-Ubl4A-Trc35 Complex |
| GO:0007029 | 2.34730462463e-07 | 0.714285714286 | WRB ASNA1 UBL4A BAG6 GET4 | endoplasmic reticulum organization |
| REAC:R-HSA-9609507 | 2.92132206586e-07 | 0.714285714286 | WRB ASNA1 UBL4A BAG6 GET4 | Protein localization |
| GO:0051205 | 4.91024341864e-07 | 0.714285714286 | WRB ASNA1 UBL4A BAG6 GET4 | protein insertion into membrane |
| GO:0071818 | 3.17865016081e-06 | 0.428571428571 | GET4 UBL4A BAG6 | BAT3 complex |
| GO:0072379 | 3.17736949706e-05 | 0.428571428571 | GET4 UBL4A BAG6 | ER membrane insertion complex |
| GO:0090150 | 0.00188808869347 | 0.714285714286 | WRB ASNA1 UBL4A BAG6 GET4 | establishment of protein localization to membrane |
| GO:0010256 | 0.00548850916005 | 0.714285714286 | WRB ASNA1 UBL4A BAG6 GET4 | endomembrane system organization |
| GO:0036506 | 0.0283955176165 | 0.285714285714 | GET4 BAG6 | maintenance of unfolded protein |
| GO:1904378 | 0.0283955176165 | 0.285714285714 | GET4 BAG6 | maintenance of unfolded protein involved in ERAD pathway |
| GO:0072657 | 0.0394916293115 | 0.714285714286 | WRB ASNA1 UBL4A BAG6 GET4 | protein localization to membrane |
| CORUM:6079 | 0.0499886427319 | 0.142857142857 | BAG6 | BAG6-HSPA2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UBL4A | BAG6 | 1.0 | 0.949 | hein_WMM bioplex (UBL4A) bioplex_WMM boldt hein (BAG6) Malo fraction boldt_WMM |
| GET4 | UBL4A | 1.0 | 0.949 | hein_WMM bioplex (GET4,UBL4A) bioplex_WMM boldt hein (GET4) boldt_WMM |
| GET4 | BAG6 | 1.0 | 0.949 | hein_WMM bioplex (GET4) bioplex_WMM boldt hein (BAG6,GET4) boldt_WMM |
| RNF126 | GET4 | 0.977 | 0.893 | hein_WMM bioplex (RNF126) bioplex_WMM boldt hein (GET4) boldt_WMM |
| RNF126 | BAG6 | 0.975 | 0.887 | hein_WMM bioplex (RNF126) bioplex_WMM boldt hein (BAG6) boldt_WMM |
| GET4 | ASNA1 | 0.864 | 0.801 | hein_WMM bioplex (ASNA1,GET4) bioplex_WMM boldt hein (ASNA1,GET4) boldt_WMM |
| UBL4A | ASNA1 | 0.552 | 0.644 | hein_WMM bioplex (ASNA1,UBL4A) bioplex_WMM boldt hein (ASNA1) boldt_WMM |
| BAG6 | ASNA1 | 0.337 | 0.526 | hein_WMM bioplex (ASNA1) bioplex_WMM boldt hein (ASNA1) boldt_WMM |
| ASNA1 | WRB | 0.043 | 0.272 | bioplex (ASNA1) bioplex_WMM |
| MINDY1 | RNF126 | 0.035 | 0.265 | bioplex (RNF126) bioplex_WMM |
| RNF126 | ASNA1 | 0.021 | 0.187 | hein_WMM bioplex (RNF126) bioplex_WMM boldt boldt_WMM |
| MINDY1 | ASNA1 | 0.008 | 0.079 | bioplex_WMM WMM_only |
| MINDY1 | BAG6 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| MINDY1 | UBL4A | 0.006 | 0.004 | bioplex_WMM WMM_only |
| MINDY1 | GET4 | 0.006 | 0.004 | bioplex_WMM WMM_only |
| BAG6 | WRB | 0.005 | 0.009 | bioplex_WMM WMM_only |
| UBL4A | WRB | 0.005 | 0.006 | bioplex_WMM WMM_only |
| GET4 | WRB | 0.005 | 0.008 | bioplex_WMM WMM_only |
| RNF126 | UBL4A | 0.004 | 0.01 | hein_WMM bioplex (RNF126) bioplex_WMM boldt boldt_WMM |
Images
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Complex HuMAP2_04160 has an average edge precision of 0.392 which is ranked 3410 out of all 6965 complexes.
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