hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04165
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SPAST | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | UniProt NCBI |
| CHMP1A | Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting-associated protein 46-1) (Vps46-1) (hVps46-1) | UniProt NCBI |
| CHMP4B | Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2) | UniProt NCBI |
| IST1 | IST1 homolog (hIST1) (Putative MAPK-activating protein PM28) | UniProt NCBI |
| LHX4 | LIM/homeobox protein Lhx4 (LIM homeobox protein 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1186 | 0.000301566439547 | 0.4 | CHMP1A CHMP4B | ESCRT-III complex |
| GO:0061640 | 0.000339213476695 | 0.8 | IST1 CHMP4B SPAST CHMP1A | cytoskeleton-dependent cytokinesis |
| KEGG:04144 | 0.00171388219445 | 0.6 | IST1 CHMP1A CHMP4B | Endocytosis |
| GO:0000910 | 0.00245191852964 | 0.8 | IST1 CHMP4B SPAST CHMP1A | cytokinesis |
| GO:0036258 | 0.00367721278555 | 0.6 | IST1 CHMP1A CHMP4B | multivesicular body assembly |
| GO:0036257 | 0.00407078924856 | 0.6 | IST1 CHMP1A CHMP4B | multivesicular body organization |
| GO:0032506 | 0.005924931483 | 0.6 | CHMP4B SPAST CHMP1A | cytokinetic process |
| GO:0051301 | 0.00896454920435 | 0.8 | IST1 CHMP4B SPAST CHMP1A | cell division |
| GO:0000281 | 0.0432266328844 | 0.6 | CHMP4B SPAST CHMP1A | mitotic cytokinesis |
| KEGG:04217 | 0.0482876775804 | 0.4 | CHMP1A CHMP4B | Necroptosis |
| GO:0007032 | 0.0493791608738 | 0.6 | IST1 CHMP1A CHMP4B | endosome organization |
| CORUM:6569 | 0.0499494897235 | 0.2 | SPAST | SPG4-SPG33 complex |
| CORUM:6615 | 0.0499494897235 | 0.2 | SPAST | SPG4-SPG12 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SPAST | IST1 | 0.833 | 0.78 | hein_WMM bioplex (SPAST) bioplex_WMM hein (SPAST) |
| CHMP4B | CHMP1A | 0.049 | 0.295 | hein_WMM bioplex_WMM hein (CHMP4B) |
| IST1 | CHMP1A | 0.042 | 0.27 | hein_WMM bioplex (IST1) bioplex_WMM |
| CHMP4B | IST1 | 0.038 | 0.264 | hein_WMM bioplex (IST1) bioplex_WMM hein (CHMP4B) |
| LHX4 | CHMP1A | 0.02 | 0.188 | bioplex (LHX4) bioplex_WMM |
| SPAST | CHMP1A | 0.008 | 0.028 | hein_WMM hein (SPAST) |
| CHMP4B | LHX4 | 0.006 | 0.012 | bioplex (LHX4) bioplex_WMM |
| CHMP4B | SPAST | 0.003 | 0.014 | hein_WMM bioplex (SPAST) bioplex_WMM youn_WMM hein (CHMP4B,SPAST) |
Images
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Complex HuMAP2_04165 has an average edge precision of 0.231 which is ranked 5670 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SPAST | HuMAP2_00139 HuMAP2_01825 HuMAP2_03424 HuMAP2_03551 HuMAP2_03593 HuMAP2_04165 HuMAP2_05586 |
| CHMP1A | HuMAP2_03424 HuMAP2_04165 HuMAP2_04361 HuMAP2_04528 |
| CHMP4B | HuMAP2_00024 HuMAP2_00246 HuMAP2_01637 HuMAP2_03424 HuMAP2_04165 HuMAP2_04361 HuMAP2_04528 |
| IST1 | HuMAP2_00139 HuMAP2_03424 HuMAP2_04165 |
| LHX4 | HuMAP2_01167 HuMAP2_04165 HuMAP2_06632 |