hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04169
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LAMA5 | Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha) | UniProt NCBI |
| UGGT2 | UDP-glucose:glycoprotein glucosyltransferase 2 (UGT2) (hUGT2) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase 2) (UDP-glucose ceramide glucosyltransferase-like 1) | UniProt NCBI |
| LAMC1 | Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) | UniProt NCBI |
| LAMB2 | Laminin subunit beta-2 (Laminin B1s chain) (Laminin-11 subunit beta) (Laminin-14 subunit beta) (Laminin-15 subunit beta) (Laminin-3 subunit beta) (Laminin-4 subunit beta) (Laminin-7 subunit beta) (Laminin-9 subunit beta) (S-laminin subunit beta) (S-LAM beta) | UniProt NCBI |
| EEA1 | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | UniProt NCBI |
| LAMB1 | Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP453 | 1.80670460392e-09 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Inflammatory Response Pathway |
| WP:WP244 | 1.23366697315e-08 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Alpha 6 Beta 4 signaling pathway |
| CORUM:2319 | 2.25288169953e-08 | 0.5 | LAMC1 LAMA5 LAMB2 | ITGA6-ITGB4-Laminin10/12 complex |
| CORUM:2318 | 2.25288169953e-08 | 0.5 | LAMC1 LAMA5 LAMB1 | ITGA6-ITGB4-Laminin10/12 complex |
| REAC:R-HSA-8874081 | 2.45022188621e-08 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | MET activates PTK2 signaling |
| GO:0043256 | 2.56043303928e-08 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | laminin complex |
| REAC:R-HSA-3000157 | 3.27882210208e-08 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Laminin interactions |
| REAC:R-HSA-8875878 | 7.89588505076e-08 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | MET promotes cell motility |
| REAC:R-HSA-3000171 | 4.71230645899e-07 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Non-integrin membrane-ECM interactions |
| KEGG:04512 | 4.79476375504e-07 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | ECM-receptor interaction |
| KEGG:05146 | 6.80094402209e-07 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Amoebiasis |
| REAC:R-HSA-3000178 | 8.58955665617e-07 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | ECM proteoglycans |
| KEGG:05222 | 9.37805281521e-07 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Small cell lung cancer |
| WP:WP4658 | 9.53390687704e-07 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Small cell lung cancer |
| KEGG:05145 | 1.02328638119e-06 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Toxoplasmosis |
| REAC:R-HSA-6806834 | 1.29621455882e-06 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Signaling by MET |
| GO:0043260 | 1.81637152046e-06 | 0.5 | LAMC1 LAMA5 LAMB2 | laminin-11 complex |
| GO:0043259 | 1.81637152046e-06 | 0.5 | LAMC1 LAMA5 LAMB1 | laminin-10 complex |
| WP:WP306 | 1.49438226774e-05 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Focal Adhesion |
| KEGG:04510 | 1.71027631169e-05 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Focal adhesion |
| GO:0044420 | 2.40824494048e-05 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | extracellular matrix component |
| WP:WP3932 | 5.14401834864e-05 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| GO:0005604 | 6.49684869516e-05 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | basement membrane |
| WP:WP4172 | 8.1191833253e-05 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | PI3K-Akt Signaling Pathway |
| KEGG:04151 | 0.00010854557604 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | PI3K-Akt signaling pathway |
| WP:WP2806 | 0.000121904053629 | 0.5 | LAMC1 LAMA5 LAMB1 | Human Complement System |
| KEGG:05165 | 0.000126915092095 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Human papillomavirus infection |
| REAC:R-HSA-1474244 | 0.000241421592823 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Extracellular matrix organization |
| GO:0034446 | 0.000574036481079 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | substrate adhesion-dependent cell spreading |
| KEGG:05200 | 0.000619708787865 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Pathways in cancer |
| REAC:R-HSA-8957275 | 0.000667561375412 | 0.5 | LAMC1 LAMB1 LAMB2 | Post-translational protein phosphorylation |
| REAC:R-HSA-381426 | 0.00103737446705 | 0.5 | LAMC1 LAMB1 LAMB2 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| WP:WP2911 | 0.00116964360656 | 0.333333333333 | LAMC1 LAMB2 | miRNA targets in ECM and membrane receptors |
| REAC:R-HSA-9006934 | 0.00129372739211 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-1474228 | 0.00199485952479 | 0.5 | LAMC1 LAMA5 LAMB1 | Degradation of the extracellular matrix |
| GO:0005201 | 0.0038519413587 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | extracellular matrix structural constituent |
| WP:WP2572 | 0.0107960863784 | 0.333333333333 | LAMB2 LAMA5 | Primary Focal Segmental Glomerulosclerosis FSGS |
| GO:0005606 | 0.020283420769 | 0.333333333333 | LAMC1 LAMB1 | laminin-1 complex |
| GO:0031589 | 0.0405607523961 | 0.666666666667 | LAMC1 LAMB1 LAMA5 LAMB2 | cell-substrate adhesion |
| GO:0005788 | 0.0488951273836 | 0.666666666667 | LAMC1 LAMB1 UGGT2 LAMB2 | endoplasmic reticulum lumen |
| CORUM:2572 | 0.0499726005494 | 0.166666666667 | EEA1 | RAB5-EEA1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LAMC1 | LAMB2 | 0.354 | 0.539 | bioplex_WMM fraction |
| LAMC1 | LAMA5 | 0.288 | 0.489 | bioplex_WMM Guru fraction |
| LAMC1 | LAMB1 | 0.096 | 0.358 | bioplex_WMM fraction |
| LAMB2 | LAMA5 | 0.09 | 0.355 | bioplex_WMM fraction |
| LAMB1 | UGGT2 | 0.049 | 0.295 | bioplex_WMM fraction |
| LAMC1 | EEA1 | 0.048 | 0.294 | bioplex_WMM fraction |
| LAMB1 | EEA1 | 0.022 | 0.208 | fraction |
| LAMB2 | EEA1 | 0.017 | 0.175 | fraction |
| LAMA5 | LAMB1 | 0.016 | 0.157 | bioplex_WMM fraction |
| LAMA5 | UGGT2 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| EEA1 | UGGT2 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| LAMB2 | LAMB1 | 0.006 | 0.006 | bioplex_WMM WMM_only |
| LAMC1 | UGGT2 | 0.004 | 0.018 | bioplex_WMM Guru gupta_WMM fraction |
| LAMB2 | UGGT2 | 0.0 | 0.012 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_04169 has an average edge precision of 0.208 which is ranked 6067 out of all 6965 complexes.
Related Complexes