hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04178
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| INO80 | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | UniProt NCBI |
| ACTR8 | Actin-related protein 8 (hArp8) (INO80 complex subunit N) | UniProt NCBI |
| ACTR5 | Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16) | UniProt NCBI |
| NFRKB | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | UniProt NCBI |
| INO80E | INO80 complex subunit E (Coiled-coil domain-containing protein 95) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:302 | 1.56890048151e-14 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | INO80 chromatin remodeling complex |
| REAC:R-HSA-5696394 | 1.23109960631e-11 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | DNA Damage Recognition in GG-NER |
| GO:0031011 | 2.460035955e-11 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | Ino80 complex |
| GO:0033202 | 2.460035955e-11 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | DNA helicase complex |
| GO:0097346 | 4.35237130501e-10 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | INO80-type complex |
| REAC:R-HSA-5696399 | 7.57189610424e-10 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5689603 | 1.84655669842e-09 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | UCH proteinases |
| REAC:R-HSA-5696398 | 3.00186385179e-09 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | Nucleotide Excision Repair |
| GO:0070603 | 1.61854596378e-07 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | SWI/SNF superfamily-type complex |
| GO:1904949 | 1.96934078318e-07 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | ATPase complex |
| REAC:R-HSA-5688426 | 2.62087849191e-07 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | Deubiquitination |
| REAC:R-HSA-73894 | 6.75134786288e-07 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | DNA Repair |
| GO:0016579 | 5.78361624972e-05 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | protein deubiquitination |
| GO:0070646 | 7.95557043395e-05 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | protein modification by small protein removal |
| REAC:R-HSA-597592 | 0.000641406598892 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | Post-translational protein modification |
| REAC:R-HSA-392499 | 0.0039377533293 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | Metabolism of proteins |
| GO:0000790 | 0.0171953090779 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | nuclear chromatin |
| GO:0070647 | 0.023802724014 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | protein modification by small protein conjugation or removal |
| GO:0000785 | 0.0394223237212 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | chromatin |
| GO:0044454 | 0.046479053704 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | nuclear chromosome part |
| CORUM:0000000 | 0.0474603483533 | 1.0 | INO80E ACTR8 ACTR5 INO80 NFRKB | CORUM root |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ACTR5 | INO80E | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| INO80 | ACTR5 | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| NFRKB | ACTR5 | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| INO80 | INO80E | 0.999 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| NFRKB | INO80E | 0.998 | 0.944 | hein_WMM bioplex_WMM Malo fraction |
| NFRKB | ACTR8 | 0.998 | 0.944 | hein_WMM bioplex_WMM youn_WMM Malo fraction |
| INO80 | NFRKB | 0.997 | 0.93 | hein_WMM bioplex_WMM Malo fraction |
| ACTR5 | ACTR8 | 0.076 | 0.358 | hein_WMM bioplex_WMM hein (ACTR5) |
| ACTR8 | INO80E | 0.021 | 0.184 | hein_WMM bioplex_WMM WMM_only |
| INO80 | ACTR8 | 0.02 | 0.187 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04178 has an average edge precision of 0.734 which is ranked 1244 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| INO80 | HuMAP2_00294 HuMAP2_01279 HuMAP2_01377 HuMAP2_04178 HuMAP2_06060 |
| ACTR8 | HuMAP2_00294 HuMAP2_01279 HuMAP2_04178 HuMAP2_06060 |
| ACTR5 | HuMAP2_00294 HuMAP2_01279 HuMAP2_01310 HuMAP2_01377 HuMAP2_04178 HuMAP2_06060 |
| NFRKB | HuMAP2_00294 HuMAP2_01279 HuMAP2_01377 HuMAP2_04178 HuMAP2_06060 |
| INO80E | HuMAP2_00294 HuMAP2_01279 HuMAP2_04178 HuMAP2_06060 |