hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04182
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HIP1R | Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) | UniProt NCBI |
| UBE2E1 | Ubiquitin-conjugating enzyme E2 E1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme E1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme E1) (UbcH6) (Ubiquitin carrier protein E1) (Ubiquitin-protein ligase E1) | UniProt NCBI |
| HIP1 | Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) | UniProt NCBI |
| GAK | Cyclin-G-associated kinase (EC 2.7.11.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8856828 | 0.000468996589794 | 0.75 | HIP1 GAK HIP1R | Clathrin-mediated endocytosis |
| GO:2000588 | 0.00270494046827 | 0.5 | HIP1 HIP1R | positive regulation of platelet-derived growth factor receptor-beta signaling pathway |
| GO:0030276 | 0.00386509246613 | 0.75 | HIP1 GAK HIP1R | clathrin binding |
| REAC:R-HSA-432722 | 0.0143225711665 | 0.5 | HIP1R GAK | Golgi Associated Vesicle Biogenesis |
| GO:0010641 | 0.0162267366884 | 0.5 | HIP1 HIP1R | positive regulation of platelet-derived growth factor receptor signaling pathway |
| REAC:R-HSA-199992 | 0.0255411590024 | 0.5 | HIP1R GAK | trans-Golgi Network Vesicle Budding |
| GO:0032051 | 0.0270421395626 | 0.5 | HIP1 HIP1R | clathrin light chain binding |
| GO:2000586 | 0.0270421395626 | 0.5 | HIP1 HIP1R | regulation of platelet-derived growth factor receptor-beta signaling pathway |
| REAC:R-HSA-199991 | 0.0426366599823 | 0.75 | HIP1 GAK HIP1R | Membrane Trafficking |
| CORUM:1130 | 0.0499140284799 | 0.25 | HIP1R | Hip1R-cortactin complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HIP1 | HIP1R | 0.041 | 0.27 | hein_WMM bioplex (HIP1R) bioplex_WMM |
| GAK | HIP1R | 0.024 | 0.214 | hein_WMM bioplex (HIP1R) bioplex_WMM youn_WMM hein (GAK) |
| HIP1R | UBE2E1 | 0.023 | 0.209 | youn_WMM fraction |
| GAK | UBE2E1 | 0.007 | 0.005 | youn_WMM gupta_WMM WMM_only |
| GAK | HIP1 | 0.004 | 0.013 | hein_WMM bioplex_WMM youn_WMM hein (GAK) |
Images
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Complex HuMAP2_04182 has an average edge precision of 0.142 which is ranked 6758 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HIP1R | HuMAP2_00186 HuMAP2_02918 HuMAP2_04182 HuMAP2_06718 |
| UBE2E1 | HuMAP2_01572 HuMAP2_03533 HuMAP2_04182 HuMAP2_04498 |
| HIP1 | HuMAP2_00186 HuMAP2_01406 HuMAP2_02918 HuMAP2_04182 HuMAP2_06718 HuMAP2_06752 |
| GAK | HuMAP2_00017 HuMAP2_02565 HuMAP2_04182 HuMAP2_05488 HuMAP2_06718 |