hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04196
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HLTF | Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) | UniProt NCBI |
| PARP2 | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | UniProt NCBI |
| CHD1L | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.12) (Amplified in liver cancer protein 1) | UniProt NCBI |
| RNF146 | E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5696400 | 0.00821677913545 | 0.5 | PARP2 CHD1L | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 0.00904685478976 | 0.5 | PARP2 CHD1L | Formation of Incision Complex in GG-NER |
| REAC:R-HSA-5696399 | 0.0347967852364 | 0.5 | PARP2 CHD1L | Global Genome Nucleotide Excision Repair (GG-NER) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PARP2 | RNF146 | 0.404 | 0.563 | bioplex (RNF146) bioplex_WMM |
| CHD1L | RNF146 | 0.077 | 0.352 | bioplex (CHD1L,RNF146) bioplex_WMM |
| PARP2 | CHD1L | 0.047 | 0.291 | bioplex (CHD1L) bioplex_WMM |
| HLTF | CHD1L | 0.032 | 0.245 | bioplex (CHD1L) bioplex_WMM |
| HLTF | PARP2 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| HLTF | RNF146 | 0.0 | 0.0 | bioplex (RNF146) bioplex_WMM |
Images
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Complex HuMAP2_04196 has an average edge precision of 0.258 which is ranked 5256 out of all 6965 complexes.
Related Complexes