hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04198
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSD17B6 | 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.239) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 6) | UniProt NCBI |
| ATP2B1 | Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1) | UniProt NCBI |
| ATP2B3 | Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-418359 | 0.000368098478948 | 0.666666666667 | ATP2B1 ATP2B3 | Reduction of cytosolic Ca++ levels |
| KEGG:04978 | 0.000462599152438 | 0.666666666667 | ATP2B1 ATP2B3 | Mineral absorption |
| KEGG:04961 | 0.000547422499549 | 0.666666666667 | ATP2B1 ATP2B3 | Endocrine and other factor-regulated calcium reabsorption |
| KEGG:04970 | 0.00120571114426 | 0.666666666667 | ATP2B1 ATP2B3 | Salivary secretion |
| KEGG:04972 | 0.00144586300556 | 0.666666666667 | ATP2B1 ATP2B3 | Pancreatic secretion |
| KEGG:04925 | 0.0017077231529 | 0.666666666667 | ATP2B1 ATP2B3 | Aldosterone synthesis and secretion |
| REAC:R-HSA-418360 | 0.00200655101382 | 0.666666666667 | ATP2B1 ATP2B3 | Platelet calcium homeostasis |
| KEGG:04261 | 0.00367632825889 | 0.666666666667 | ATP2B1 ATP2B3 | Adrenergic signaling in cardiomyocytes |
| GO:1905056 | 0.00405722906526 | 0.666666666667 | ATP2B1 ATP2B3 | calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration |
| KEGG:04022 | 0.00439265454468 | 0.666666666667 | ATP2B1 ATP2B3 | cGMP-PKG signaling pathway |
| KEGG:04020 | 0.00558575423654 | 0.666666666667 | ATP2B1 ATP2B3 | Calcium signaling pathway |
| KEGG:04024 | 0.0063848075241 | 0.666666666667 | ATP2B1 ATP2B3 | cAMP signaling pathway |
| REAC:R-HSA-5578775 | 0.00661568366637 | 0.666666666667 | ATP2B1 ATP2B3 | Ion homeostasis |
| WP:WP536 | 0.00681250105954 | 0.666666666667 | ATP2B1 ATP2B3 | Calcium Regulation in the Cardiac Cell |
| REAC:R-HSA-936837 | 0.00722314394396 | 0.666666666667 | ATP2B1 ATP2B3 | Ion transport by P-type ATPases |
| GO:1990034 | 0.00811409485621 | 0.666666666667 | ATP2B1 ATP2B3 | calcium ion export across plasma membrane |
| REAC:R-HSA-418346 | 0.0195249561753 | 0.666666666667 | ATP2B1 ATP2B3 | Platelet homeostasis |
| GO:1901660 | 0.020283420769 | 0.666666666667 | ATP2B1 ATP2B3 | calcium ion export |
| REAC:R-HSA-5576891 | 0.0392203365557 | 0.666666666667 | ATP2B1 ATP2B3 | Cardiac conduction |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATP2B3 | HSD17B6 | 0.379 | 0.549 | bioplex (HSD17B6) bioplex_WMM |
| ATP2B1 | HSD17B6 | 0.055 | 0.309 | bioplex (HSD17B6) bioplex_WMM |
| ATP2B1 | ATP2B3 | 0.01 | 0.129 | bioplex_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_04198 has an average edge precision of 0.329 which is ranked 4232 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HSD17B6 | HuMAP2_02462 HuMAP2_04031 HuMAP2_04198 |
| ATP2B1 | HuMAP2_02462 HuMAP2_04031 HuMAP2_04198 |
| ATP2B3 | HuMAP2_02462 HuMAP2_04031 HuMAP2_04198 |