hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04200

Confidence: Medium

Genename	Protein Name	Links
NEDD4	E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)	UniProt NCBI
NEDD4L	E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)	UniProt NCBI
HECW2	E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)	UniProt NCBI
FAM189A2	Protein FAM189A2 (Protein X123)	UniProt NCBI
AREL1	Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1)	UniProt NCBI
WBP1	WW domain-binding protein 1 (WBP-1)	UniProt NCBI
WWP1	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-983168	9.5203816776e-06	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	Antigen processing: Ubiquitination & Proteasome degradation
REAC:R-HSA-983169	2.32006456929e-05	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	Class I MHC mediated antigen processing & presentation
GO:0061630	0.000138693208403	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	ubiquitin protein ligase activity
GO:0061659	0.000188293700604	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	ubiquitin-like protein ligase activity
GO:0045732	0.000199727410561	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	positive regulation of protein catabolic process
GO:2000650	0.000266683990267	0.428571428571	HECW2 NEDD4L NEDD4	negative regulation of sodium ion transmembrane transporter activity
GO:1902306	0.000380900357231	0.428571428571	HECW2 NEDD4L NEDD4	negative regulation of sodium ion transmembrane transport
REAC:R-HSA-1280218	0.000501292413155	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	Adaptive Immune System
REAC:R-HSA-1253288	0.00088537905131	0.285714285714	NEDD4 WWP1	Downregulation of ERBB4 signaling
GO:0010766	0.00115446662879	0.428571428571	HECW2 NEDD4L NEDD4	negative regulation of sodium ion transport
KEGG:04120	0.00116183627381	0.428571428571	WWP1 NEDD4L NEDD4	Ubiquitin mediated proteolysis
GO:0000209	0.00195942787934	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	protein polyubiquitination
GO:0042176	0.00304702025578	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	regulation of protein catabolic process
GO:0004842	0.00353922861157	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	ubiquitin-protein transferase activity
GO:0019787	0.00524604197907	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	ubiquitin-like protein transferase activity
GO:0009896	0.0055712861171	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	positive regulation of catabolic process
KEGG:04144	0.00645172813212	0.428571428571	WWP1 NEDD4L NEDD4	Endocytosis
GO:0043161	0.00844048511333	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0010498	0.0162475978721	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	proteasomal protein catabolic process
GO:2000649	0.02067047809	0.428571428571	HECW2 NEDD4L NEDD4	regulation of sodium ion transmembrane transporter activity
REAC:R-HSA-1236394	0.0324500337431	0.285714285714	NEDD4 WWP1	Signaling by ERBB4
GO:0006511	0.0353227467398	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	ubiquitin-dependent protein catabolic process
GO:0019941	0.0367960409581	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	modification-dependent protein catabolic process
GO:0032413	0.0389125948999	0.428571428571	HECW2 NEDD4L NEDD4	negative regulation of ion transmembrane transporter activity
GO:0043632	0.0411010330406	0.714285714286	HECW2 WWP1 AREL1 NEDD4L NEDD4	modification-dependent macromolecule catabolic process
GO:1902305	0.0417514312642	0.428571428571	HECW2 NEDD4L NEDD4	regulation of sodium ion transmembrane transport
CORUM:6690	0.0499886427319	0.142857142857	NEDD4	NEDD4-PI4K2A complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
HECW2	FAM189A2	0.156	0.415	bioplex (FAM189A2) bioplex_WMM
NEDD4L	FAM189A2	0.155	0.415	bioplex (FAM189A2) bioplex_WMM
NEDD4L	WBP1	0.068	0.347	bioplex (WBP1) bioplex_WMM
NEDD4	FAM189A2	0.062	0.341	bioplex (FAM189A2) bioplex_WMM
FAM189A2	WWP1	0.058	0.325	bioplex (FAM189A2) bioplex_WMM
NEDD4L	NEDD4	0.05	0.298	bioplex_WMM WMM_only
FAM189A2	AREL1	0.031	0.24	bioplex (FAM189A2) bioplex_WMM
WBP1	WWP1	0.024	0.213	bioplex (WBP1) bioplex_WMM
NEDD4	WWP1	0.02	0.186	bioplex_WMM WMM_only
NEDD4L	WWP1	0.019	0.183	bioplex_WMM WMM_only
HECW2	WWP1	0.017	0.175	bioplex_WMM WMM_only
NEDD4L	HECW2	0.016	0.165	bioplex_WMM WMM_only
NEDD4	HECW2	0.016	0.159	bioplex_WMM WMM_only
HECW2	AREL1	0.008	0.045	bioplex_WMM WMM_only
NEDD4L	AREL1	0.007	0.012	bioplex_WMM WMM_only
NEDD4	AREL1	0.007	0.004	bioplex_WMM WMM_only
WWP1	AREL1	0.007	0.009	bioplex_WMM WMM_only
WBP1	NEDD4	0.006	0.003	bioplex (WBP1) bioplex_WMM
WBP1	HECW2	0.006	0.006	bioplex (WBP1) bioplex_WMM

Images

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Complex HuMAP2_04200 has an average edge precision of 0.186 which is ranked 6354 out of all 6965 complexes.

Related Complexes

Genename	Complexes
NEDD4	HuMAP2_02724 HuMAP2_04200
NEDD4L	HuMAP2_01315 HuMAP2_02724 HuMAP2_04200
HECW2	HuMAP2_02724 HuMAP2_04200
FAM189A2	HuMAP2_02724 HuMAP2_04200
AREL1	HuMAP2_03167 HuMAP2_03571 HuMAP2_04200
WBP1	HuMAP2_01315 HuMAP2_01416 HuMAP2_02724 HuMAP2_04200
WWP1	HuMAP2_02724 HuMAP2_04200 HuMAP2_06558

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04200