hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04204

Confidence: High

Genename	Protein Name	Links
TPM1	Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)	UniProt NCBI
TPM2	Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)	UniProt NCBI
MYH7B	Myosin-7B (Antigen MLAA-21) (Myosin cardiac muscle beta chain) (Myosin heavy chain 7B, cardiac muscle beta isoform) (Slow A MYH14)	UniProt NCBI
MYH6	Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)	UniProt NCBI
TPM3	Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)	UniProt NCBI
TPM4	Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)	UniProt NCBI
ACTN4	Alpha-actinin-4 (Non-muscle alpha-actinin 4)	UniProt NCBI
ACTN1	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP383	2.16722457984e-13	0.75	TPM2 TPM1 ACTN4 TPM4 TPM3 MYH6	Striated Muscle Contraction Pathway
REAC:R-HSA-390522	5.2544449687e-10	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	Striated Muscle Contraction
GO:0005862	1.70768929464e-09	0.5	TPM1 TPM4 TPM2 TPM3	muscle thin filament tropomyosin
KEGG:04260	8.05256076288e-09	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	Cardiac muscle contraction
KEGG:05410	1.1158182313e-08	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	Hypertrophic cardiomyopathy (HCM)
KEGG:05414	1.42754002314e-08	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	Dilated cardiomyopathy (DCM)
KEGG:04261	1.18897017972e-07	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	Adrenergic signaling in cardiomyocytes
GO:0030048	1.47066608718e-07	0.75	TPM2 TPM1 ACTN4 TPM4 TPM3 MYH6	actin filament-based movement
GO:0033275	2.28991321124e-07	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	actin-myosin filament sliding
GO:0030049	2.28991321124e-07	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	muscle filament sliding
REAC:R-HSA-445355	2.46255883029e-07	0.5	TPM1 TPM4 TPM2 TPM3	Smooth Muscle Contraction
GO:0051015	9.30936297466e-07	0.75	TPM2 TPM1 ACTN1 ACTN4 TPM4 TPM3	actin filament binding
REAC:R-HSA-397014	1.87102943214e-06	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	Muscle contraction
GO:0015629	2.96524383428e-06	0.875	TPM2 TPM1 ACTN1 ACTN4 TPM4 TPM3 MYH6	actin cytoskeleton
GO:0005865	8.24534072683e-06	0.5	TPM1 TPM4 TPM2 TPM3	striated muscle thin filament
GO:0036379	1.24434934399e-05	0.5	TPM1 TPM4 TPM2 TPM3	myofilament
GO:0070252	1.57602037409e-05	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	actin-mediated cell contraction
GO:0005884	2.91101691159e-05	0.625	TPM1 TPM4 TPM2 ACTN1 TPM3	actin filament
GO:0003779	3.98359373309e-05	0.75	TPM2 TPM1 ACTN1 ACTN4 TPM4 TPM3	actin binding
GO:0030029	4.6559109671e-05	0.875	TPM2 TPM1 ACTN1 ACTN4 TPM4 TPM3 MYH6	actin filament-based process
GO:0030017	8.219111489e-05	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	sarcomere
GO:0030016	0.000138895560635	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	myofibril
GO:0044449	0.000149864331431	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	contractile fiber part
GO:0043292	0.000193820981193	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	contractile fiber
HP:0001644	0.000205410820799	0.5	TPM3 TPM1 TPM2 MYH6	Dilated cardiomyopathy
MIRNA:hsa-miR-1-3p	0.000237050282163	0.75	TPM2 TPM1 ACTN1 ACTN4 TPM4 TPM3	hsa-miR-1-3p
HP:0010876	0.000345619363438	0.625	TPM3 TPM1 ACTN4 TPM2 MYH6	Abnormal circulating protein level
GO:0001725	0.000358332164808	0.5	TPM1 ACTN1 TPM3 TPM4	stress fiber
GO:0097517	0.000358332164808	0.5	TPM1 ACTN1 TPM3 TPM4	contractile actin filament bundle
GO:0032432	0.000534279096056	0.5	TPM1 ACTN1 TPM3 TPM4	actin filament bundle
GO:0042641	0.000666904519799	0.5	TPM1 ACTN1 TPM3 TPM4	actomyosin
GO:0006936	0.00169430181981	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	muscle contraction
HP:0003457	0.00172456334652	0.5	TPM3 TPM1 TPM2 MYH6	EMG abnormality
GO:0030036	0.00179387491837	0.75	TPM2 TPM1 ACTN1 TPM4 TPM3 MYH6	actin cytoskeleton organization
GO:0097435	0.00181549203686	0.75	TPM2 TPM1 ACTN1 TPM4 TPM3 MYH6	supramolecular fiber organization
HP:0003236	0.00234755852173	0.5	TPM3 TPM1 TPM2 MYH6	Elevated serum creatine kinase
KEGG:04530	0.00234785851362	0.375	MYH7B ACTN1 ACTN4	Tight junction
GO:0099512	0.00234876916508	0.75	TPM2 TPM1 ACTN1 TPM4 TPM3 MYH6	supramolecular fiber
HP:0003755	0.00248871678952	0.25	TPM2 TPM3	Type 1 fibers relatively smaller than type 2 fibers
GO:0099081	0.00251484937643	0.75	TPM2 TPM1 ACTN1 TPM4 TPM3 MYH6	supramolecular polymer
GO:0099080	0.00254345393241	0.75	TPM2 TPM1 ACTN1 TPM4 TPM3 MYH6	supramolecular complex
HP:0040081	0.00269253652949	0.5	TPM3 TPM1 TPM2 MYH6	Abnormal circulating creatine kinase concentration
HP:0011021	0.00273816527344	0.5	TPM3 TPM1 TPM2 MYH6	Abnormality of circulating enzyme level
HP:0003198	0.00338513780385	0.5	TPM3 TPM1 TPM2 MYH6	Myopathy
GO:0003012	0.00379847061121	0.625	TPM3 TPM1 TPM4 TPM2 MYH6	muscle system process
HP:0002068	0.00464310919637	0.25	TPM2 TPM3	Neuromuscular dysphagia
HP:0006673	0.00464310919637	0.25	TPM2 TPM3	Reduced systolic function
GO:0007015	0.00709427990716	0.625	TPM1 TPM4 TPM2 ACTN1 TPM3	actin filament organization
HP:0032341	0.00745813121128	0.25	TPM2 TPM3	Reduced forced vital capacity
HP:0011675	0.00910846699974	0.5	TPM3 TPM1 TPM2 MYH6	Arrhythmia
REAC:R-HSA-373753	0.0102847477438	0.25	ACTN4 ACTN1	Nephrin family interactions
HP:0030200	0.0109327161708	0.25	TPM2 TPM3	Fatiguable weakness of proximal limb muscles
HP:0030956	0.0126685812944	0.5	TPM3 TPM1 TPM2 MYH6	Abnormality of cardiovascular system electrophysiology
HP:0000006	0.0130640029998	0.75	TPM2 TPM1 ACTN1 ACTN4 MYH6 TPM3	Autosomal dominant inheritance
HP:0003798	0.0150657984869	0.25	TPM2 TPM3	Nemaline bodies
HP:0007110	0.0150657984869	0.25	TPM2 TPM3	Central hypoventilation
GO:0008092	0.0154530953556	0.75	TPM2 TPM1 ACTN1 ACTN4 TPM4 TPM3	cytoskeletal protein binding
HP:0011807	0.0173789434513	0.25	TPM2 TPM3	Type 1 muscle fiber atrophy
HP:0032180	0.0179063560995	0.625	TPM3 TPM1 ACTN4 TPM2 MYH6	Abnormal circulating metabolite concentration
HP:0009055	0.0198563136463	0.25	TPM2 TPM3	Generalized limb muscle atrophy
HP:0001638	0.021879554628	0.5	TPM3 TPM1 TPM2 MYH6	Cardiomyopathy
GO:0006928	0.0224630117331	0.875	TPM2 TPM1 ACTN1 ACTN4 TPM4 TPM3 MYH6	movement of cell or subcellular component
HP:0011703	0.0253031982095	0.25	TPM2 TPM3	Sinus tachycardia
HP:0001623	0.0253031982095	0.25	TPM2 TPM3	Breech presentation
GO:0044877	0.0253046645697	0.75	TPM2 TPM1 ACTN1 ACTN4 TPM4 TPM3	protein-containing complex binding
HP:0011025	0.026147316213	0.625	TPM3 TPM1 ACTN4 TPM2 MYH6	Abnormal cardiovascular system physiology
HP:0001637	0.0264848027917	0.5	TPM3 TPM1 TPM2 MYH6	Abnormal myocardium morphology
KEGG:04520	0.0279665014883	0.25	ACTN4 ACTN1	Adherens junction
HP:0008081	0.0282724469862	0.25	TPM2 TPM3	Pes valgus
GO:0099513	0.0291592221593	0.625	TPM1 TPM4 TPM2 ACTN1 TPM3	polymeric cytoskeletal fiber
WP:WP2118	0.0294384226193	0.25	ACTN4 ACTN1	Arrhythmogenic Right Ventricular Cardiomyopathy
HP:0032340	0.0314053898103	0.25	TPM2 TPM3	Abnormal spirometry test
GO:0005856	0.0335519954693	0.875	TPM2 TPM1 ACTN1 ACTN4 TPM4 TPM3 MYH6	cytoskeleton
HP:0001989	0.0381618271547	0.25	TPM2 TPM3	Fetal akinesia sequence
GO:0008307	0.039179823435	0.375	TPM1 TPM2 TPM4	structural constituent of muscle
HP:0100303	0.0417850566195	0.25	TPM2 TPM3	Muscle fiber cytoplasmatic inclusion bodies
HP:0003687	0.0417850566195	0.25	TPM2 TPM3	Centrally nucleated skeletal muscle fibers
KEGG:05146	0.042374965807	0.25	ACTN4 ACTN1	Amoebiasis
KEGG:00000	0.045111549543	1.0	TPM2 TPM1 ACTN1 ACTN4 MYH6 MYH7B TPM3 TPM4	KEGG root term
KEGG:04670	0.0454007036402	0.25	ACTN4 ACTN1	Leukocyte transendothelial migration
HP:0030878	0.0455714500205	0.25	TPM2 TPM3	Abnormality on pulmonary function testing
HP:0002483	0.0495208749973	0.25	TPM2 TPM3	Bulbar signs
HP:0002792	0.0495208749973	0.25	TPM2 TPM3	Reduced vital capacity
CORUM:4025	0.0497224828424	0.125	ACTN1	ACTN1-PARVB complex
CORUM:5655	0.0497224828424	0.125	ACTN4	Ternary complex (LRRC7, CAMK2a, ACTN4)
CORUM:6788	0.0497224828424	0.125	ACTN4	SLC9A3R1-ACTN4 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
TPM4	TPM1	1.0	0.949	hein_WMM bioplex (TPM1) bioplex_WMM youn_WMM hein (TPM1,TPM4) gupta_WMM
TPM1	TPM3	1.0	0.949	hein_WMM bioplex (TPM1) bioplex_WMM boldt youn_WMM hein (TPM1) gupta_WMM fraction boldt_WMM treiber_WMM
TPM1	TPM2	1.0	0.949	hein_WMM bioplex (TPM1) bioplex_WMM hein (TPM1)
MYH6	TPM2	0.985	0.899	Guru fraction
TPM1	ACTN4	0.978	0.894	hein_WMM bioplex (TPM1) bioplex_WMM Guru youn_WMM hein (TPM1) gupta_WMM fraction
TPM4	MYH7B	0.972	0.886	Guru fraction
MYH7B	TPM3	0.969	0.88	Guru fraction
MYH6	TPM1	0.957	0.863	bioplex_WMM Guru fraction
TPM1	MYH7B	0.939	0.851	Guru fraction
TPM4	ACTN1	0.918	0.841	hein_WMM bioplex_WMM Guru gupta_WMM fraction
TPM1	ACTN1	0.898	0.823	hein_WMM bioplex_WMM Guru youn_WMM fraction
ACTN4	ACTN1	0.859	0.796	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
TPM4	ACTN4	0.811	0.771	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction
TPM2	ACTN4	0.801	0.766	hein_WMM bioplex_WMM Guru fraction
TPM3	ACTN1	0.647	0.686	hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM
TPM2	ACTN1	0.548	0.642	hein_WMM bioplex_WMM Guru fraction
TPM3	ACTN4	0.049	0.294	hein_WMM bioplex (TPM3) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
TPM4	TPM3	0.025	0.214	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
TPM3	TPM2	0.008	0.06	hein_WMM bioplex_WMM WMM_only
MYH6	TPM4	0.007	0.004	bioplex_WMM WMM_only
MYH6	TPM3	0.007	0.001	bioplex_WMM WMM_only
TPM4	TPM2	0.006	0.007	hein_WMM bioplex_WMM WMM_only
MYH7B	ACTN4	0.004	0.014	Guru fraction

Images

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Complex HuMAP2_04204 has an average edge precision of 0.61 which is ranked 1886 out of all 6965 complexes.

Related Complexes

Genename	Complexes
TPM1	HuMAP2_01077 HuMAP2_04204 HuMAP2_06151 HuMAP2_06387
TPM2	HuMAP2_02652 HuMAP2_04204 HuMAP2_06061 HuMAP2_06387 HuMAP2_06391
MYH7B	HuMAP2_01077 HuMAP2_04204 HuMAP2_06710
MYH6	HuMAP2_00710 HuMAP2_01870 HuMAP2_02652 HuMAP2_03104 HuMAP2_04204 HuMAP2_06061 HuMAP2_06387
TPM3	HuMAP2_01077 HuMAP2_01543 HuMAP2_04204 HuMAP2_06151
TPM4	HuMAP2_00779 HuMAP2_04204 HuMAP2_06151 HuMAP2_06387
ACTN4	HuMAP2_02652 HuMAP2_04204 HuMAP2_06387
ACTN1	HuMAP2_02652 HuMAP2_04204 HuMAP2_06387

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04204