hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04206
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ACD | Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein) | UniProt NCBI |
| TERF1 | Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1) | UniProt NCBI |
| TINF2 | TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) | UniProt NCBI |
| POT1 | Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1201 | 4.53449095762e-14 | 1.0 | TERF1 POT1 TINF2 ACD | TRF1-TIN2 complex |
| CORUM:1197 | 6.80173643643e-13 | 1.0 | TERF1 POT1 TINF2 ACD | Telomere-associated protein complex |
| CORUM:138 | 6.80173643643e-13 | 1.0 | TERF1 POT1 TINF2 ACD | Telomere-associated protein complex |
| CORUM:1204 | 1.58707183517e-12 | 1.0 | TERF1 POT1 TINF2 ACD | Rap1 complex |
| GO:0070187 | 3.6593342028e-10 | 1.0 | TERF1 POT1 TINF2 ACD | shelterin complex |
| CORUM:1198 | 2.70078815927e-09 | 0.75 | POT1 TINF2 ACD | TIN2 complex |
| GO:0000782 | 1.20758028692e-08 | 1.0 | TERF1 POT1 TINF2 ACD | telomere cap complex |
| GO:0000783 | 1.20758028692e-08 | 1.0 | TERF1 POT1 TINF2 ACD | nuclear telomere cap complex |
| CORUM:1206 | 1.3502580449e-08 | 0.75 | TERF1 TINF2 POT1 | TRF-Rap1 complex I, 2MD |
| REAC:R-HSA-171306 | 2.26633858062e-08 | 1.0 | TERF1 POT1 TINF2 ACD | Packaging Of Telomere Ends |
| REAC:R-HSA-73927 | 2.86807459968e-08 | 1.0 | TERF1 POT1 TINF2 ACD | Depurination |
| REAC:R-HSA-110330 | 2.86807459968e-08 | 1.0 | TERF1 POT1 TINF2 ACD | Recognition and association of DNA glycosylase with site containing an affected purine |
| REAC:R-HSA-110331 | 2.86807459968e-08 | 1.0 | TERF1 POT1 TINF2 ACD | Cleavage of the damaged purine |
| REAC:R-HSA-73928 | 3.84769695718e-08 | 1.0 | TERF1 POT1 TINF2 ACD | Depyrimidination |
| REAC:R-HSA-110329 | 3.84769695718e-08 | 1.0 | TERF1 POT1 TINF2 ACD | Cleavage of the damaged pyrimidine |
| REAC:R-HSA-110328 | 3.84769695718e-08 | 1.0 | TERF1 POT1 TINF2 ACD | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| REAC:R-HSA-73929 | 4.12752946315e-08 | 1.0 | TERF1 POT1 TINF2 ACD | Base-Excision Repair, AP Site Formation |
| REAC:R-HSA-1221632 | 1.10228940689e-07 | 1.0 | TERF1 POT1 TINF2 ACD | Meiotic synapsis |
| GO:0032211 | 1.1819649475e-07 | 1.0 | TERF1 POT1 TINF2 ACD | negative regulation of telomere maintenance via telomerase |
| REAC:R-HSA-2559586 | 1.36261543966e-07 | 1.0 | TERF1 POT1 TINF2 ACD | DNA Damage/Telomere Stress Induced Senescence |
| REAC:R-HSA-157579 | 1.50884279717e-07 | 1.0 | TERF1 POT1 TINF2 ACD | Telomere Maintenance |
| REAC:R-HSA-73884 | 2.01866015002e-07 | 1.0 | TERF1 POT1 TINF2 ACD | Base Excision Repair |
| GO:1904357 | 4.28142101727e-07 | 1.0 | TERF1 POT1 TINF2 ACD | negative regulation of telomere maintenance via telomere lengthening |
| REAC:R-HSA-73886 | 4.8601535637e-07 | 1.0 | TERF1 POT1 TINF2 ACD | Chromosome Maintenance |
| GO:0070198 | 5.79418977671e-07 | 1.0 | TERF1 POT1 TINF2 ACD | protein localization to chromosome, telomeric region |
| REAC:R-HSA-1500620 | 6.05161917666e-07 | 1.0 | TERF1 POT1 TINF2 ACD | Meiosis |
| GO:2000279 | 6.68560358851e-07 | 1.0 | TERF1 POT1 TINF2 ACD | negative regulation of DNA biosynthetic process |
| REAC:R-HSA-1474165 | 9.37245272258e-07 | 1.0 | TERF1 POT1 TINF2 ACD | Reproduction |
| GO:0032205 | 1.27735159239e-06 | 1.0 | TERF1 POT1 TINF2 ACD | negative regulation of telomere maintenance |
| GO:0042162 | 1.43702054144e-06 | 1.0 | TERF1 POT1 TINF2 ACD | telomeric DNA binding |
| GO:0032202 | 1.45302402969e-06 | 0.75 | POT1 TINF2 ACD | telomere assembly |
| REAC:R-HSA-2559583 | 4.57121262574e-06 | 1.0 | TERF1 POT1 TINF2 ACD | Cellular Senescence |
| GO:0032210 | 6.09645078186e-06 | 1.0 | TERF1 POT1 TINF2 ACD | regulation of telomere maintenance via telomerase |
| GO:0016233 | 7.1436302529e-06 | 1.0 | TERF1 POT1 TINF2 ACD | telomere capping |
| GO:1904356 | 1.11030542559e-05 | 1.0 | TERF1 POT1 TINF2 ACD | regulation of telomere maintenance via telomere lengthening |
| CORUM:1202 | 1.50819606993e-05 | 0.5 | TERF1 TINF2 | TRF1 telomere length regulation complex |
| GO:0007004 | 1.86987098651e-05 | 1.0 | TERF1 POT1 TINF2 ACD | telomere maintenance via telomerase |
| GO:0006278 | 1.98673792316e-05 | 1.0 | TERF1 POT1 TINF2 ACD | RNA-dependent DNA biosynthetic process |
| CORUM:1207 | 3.01612206104e-05 | 0.5 | POT1 TINF2 | TRF2-Rap1 complex II |
| GO:0032204 | 3.12988953256e-05 | 1.0 | TERF1 POT1 TINF2 ACD | regulation of telomere maintenance |
| GO:0010833 | 3.47984386015e-05 | 1.0 | TERF1 POT1 TINF2 ACD | telomere maintenance via telomere lengthening |
| GO:0034502 | 3.47984386015e-05 | 1.0 | TERF1 POT1 TINF2 ACD | protein localization to chromosome |
| REAC:R-HSA-73894 | 3.93749583955e-05 | 1.0 | TERF1 POT1 TINF2 ACD | DNA Repair |
| GO:2000278 | 5.68877655611e-05 | 1.0 | TERF1 POT1 TINF2 ACD | regulation of DNA biosynthetic process |
| GO:0051053 | 7.76643673643e-05 | 1.0 | TERF1 POT1 TINF2 ACD | negative regulation of DNA metabolic process |
| REAC:R-HSA-2262752 | 0.00010216546718 | 1.0 | TERF1 POT1 TINF2 ACD | Cellular responses to stress |
| HP:0002894 | 0.000181431813171 | 0.75 | POT1 TINF2 ACD | Neoplasm of the pancreas |
| GO:0000784 | 0.000187207512548 | 1.0 | TERF1 POT1 TINF2 ACD | nuclear chromosome, telomeric region |
| GO:2001251 | 0.000207250295865 | 1.0 | TERF1 POT1 TINF2 ACD | negative regulation of chromosome organization |
| REAC:R-HSA-8953897 | 0.00021167720149 | 1.0 | TERF1 POT1 TINF2 ACD | Cellular responses to external stimuli |
| GO:0070200 | 0.000296207880886 | 0.75 | TERF1 ACD POT1 | establishment of protein localization to telomere |
| GO:0032993 | 0.000342608092204 | 1.0 | TERF1 POT1 TINF2 ACD | protein-DNA complex |
| GO:0000781 | 0.000363289575714 | 1.0 | TERF1 POT1 TINF2 ACD | chromosome, telomeric region |
| GO:0071897 | 0.000407446981099 | 1.0 | TERF1 POT1 TINF2 ACD | DNA biosynthetic process |
| HP:0000488 | 0.000462085695464 | 0.75 | POT1 TINF2 ACD | Retinopathy |
| GO:0000723 | 0.000494260781771 | 1.0 | TERF1 POT1 TINF2 ACD | telomere maintenance |
| REAC:R-HSA-1640170 | 0.000545854331888 | 1.0 | TERF1 POT1 TINF2 ACD | Cell Cycle |
| GO:0032200 | 0.000691429733885 | 1.0 | TERF1 POT1 TINF2 ACD | telomere organization |
| HP:0000958 | 0.000831010499476 | 0.75 | POT1 TINF2 ACD | Dry skin |
| GO:0070199 | 0.00106129291317 | 0.75 | TERF1 ACD POT1 | establishment of protein localization to chromosome |
| HP:0002745 | 0.0038810174634 | 0.5 | TINF2 ACD | Oral leukoplakia |
| HP:0025125 | 0.0038810174634 | 0.5 | TINF2 ACD | White lesion of the oral mucosa |
| GO:0051972 | 0.00416219722544 | 0.75 | TERF1 ACD POT1 | regulation of telomerase activity |
| HP:0001915 | 0.00431185527855 | 0.5 | TINF2 ACD | Aplastic anemia |
| HP:0010450 | 0.00431185527855 | 0.5 | TINF2 ACD | Esophageal stenosis |
| GO:0051052 | 0.0047530290566 | 1.0 | TERF1 POT1 TINF2 ACD | regulation of DNA metabolic process |
| HP:0001732 | 0.00521370204815 | 0.75 | POT1 TINF2 ACD | Abnormality of the pancreas |
| GO:0098687 | 0.00552286185544 | 1.0 | TERF1 POT1 TINF2 ACD | chromosomal region |
| GO:0033044 | 0.00577104631755 | 1.0 | TERF1 POT1 TINF2 ACD | regulation of chromosome organization |
| GO:0010639 | 0.00585560377275 | 1.0 | TERF1 POT1 TINF2 ACD | negative regulation of organelle organization |
| GO:0060249 | 0.00629241325149 | 1.0 | TERF1 POT1 TINF2 ACD | anatomical structure homeostasis |
| HP:0002216 | 0.00920632571228 | 0.5 | TINF2 ACD | Premature graying of hair |
| HP:0007392 | 0.00986303631958 | 0.5 | TINF2 ACD | Excessive wrinkled skin |
| HP:0011358 | 0.0119684664945 | 0.5 | TINF2 ACD | Generalized hypopigmentation of hair |
| HP:0007440 | 0.0150911756538 | 0.5 | TINF2 ACD | Generalized hyperpigmentation |
| HP:0001000 | 0.0184741317158 | 0.75 | POT1 TINF2 ACD | Abnormality of skin pigmentation |
| HP:0100678 | 0.01857406376 | 0.5 | TINF2 ACD | Premature skin wrinkling |
| HP:0001480 | 0.01857406376 | 0.5 | POT1 ACD | Freckling |
| HP:0005528 | 0.0224167415402 | 0.5 | TINF2 ACD | Bone marrow hypocellularity |
| CORUM:2219 | 0.0249595281251 | 0.25 | TERF1 | TERF1 homodimer complex |
| HP:0006753 | 0.0360996225593 | 0.5 | POT1 ACD | Neoplasm of the stomach |
| HP:0002861 | 0.0373855400094 | 0.5 | POT1 ACD | Melanoma |
| HP:0010987 | 0.037691835903 | 0.75 | POT1 TINF2 ACD | Abnormal cellular immune system morphology |
| HP:0001881 | 0.037691835903 | 0.75 | POT1 TINF2 ACD | Abnormal leukocyte morphology |
| HP:0032251 | 0.0406864321028 | 0.75 | POT1 TINF2 ACD | Abnormal immune system morphology |
| HP:0004334 | 0.049965329079 | 0.5 | TINF2 ACD | Dermal atrophy |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TINF2 | TERF1 | 1.0 | 0.949 | hein_WMM bioplex (TERF1,TINF2) bioplex_WMM hein (TERF1) |
| ACD | POT1 | 1.0 | 0.949 | hein_WMM bioplex (ACD,POT1) bioplex_WMM hein (POT1) |
| TINF2 | POT1 | 0.999 | 0.949 | hein_WMM bioplex (POT1,TINF2) bioplex_WMM hein (POT1) |
| TERF1 | POT1 | 0.999 | 0.949 | hein_WMM bioplex (POT1,TERF1) bioplex_WMM hein (POT1,TERF1) |
| TERF1 | ACD | 0.972 | 0.886 | hein_WMM bioplex (TERF1) bioplex_WMM hein (TERF1) |
| TINF2 | ACD | 0.709 | 0.728 | hein_WMM bioplex (ACD,TINF2) bioplex_WMM |
Images
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Complex HuMAP2_04206 has an average edge precision of 0.902 which is ranked 545 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ACD | HuMAP2_01336 HuMAP2_03683 HuMAP2_04206 HuMAP2_06271 |
| TERF1 | HuMAP2_01135 HuMAP2_01336 HuMAP2_03683 HuMAP2_04206 HuMAP2_06271 |
| TINF2 | HuMAP2_01135 HuMAP2_01336 HuMAP2_03683 HuMAP2_04206 HuMAP2_06271 |
| POT1 | HuMAP2_01336 HuMAP2_03683 HuMAP2_04206 HuMAP2_06271 |