hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04207
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ACTR10 | Actin-related protein 10 (Actin-related protein 11) (hARP11) | UniProt NCBI |
| DCTN3 | Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit) (p22) | UniProt NCBI |
| DCTN6 | Dynactin subunit 6 (Dynactin subunit p27) (Protein WS-3) | UniProt NCBI |
| DCTN2 | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | UniProt NCBI |
| ACTR1A | Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) | UniProt NCBI |
| ACTR1B | Beta-centractin (Actin-related protein 1B) (ARP1B) | UniProt NCBI |
| DCTN4 | Dynactin subunit 4 (Dyn4) (Dynactin subunit p62) | UniProt NCBI |
| DCTN5 | Dynactin subunit 5 (Dynactin subunit p25) | UniProt NCBI |
| DCTN1 | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2132295 | 1.53167677199e-17 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | MHC class II antigen presentation |
| REAC:R-HSA-6811436 | 1.60166131621e-17 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 2.24476599362e-17 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| GO:0005869 | 2.77300804133e-16 | 0.666666666667 | DCTN3 ACTR1A DCTN2 DCTN4 ACTR1B ACTR10 | dynactin complex |
| GO:0019886 | 3.20540818382e-16 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| GO:0002495 | 3.56156464869e-16 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | antigen processing and presentation of peptide antigen via MHC class II |
| GO:0002504 | 3.95246808574e-16 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| REAC:R-HSA-6807878 | 4.29931724365e-15 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | COPI-mediated anterograde transport |
| REAC:R-HSA-8856688 | 4.82217847308e-14 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | Golgi-to-ER retrograde transport |
| GO:0002478 | 9.01522190607e-14 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | antigen processing and presentation of exogenous peptide antigen |
| GO:0019884 | 1.00889952348e-13 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | antigen processing and presentation of exogenous antigen |
| REAC:R-HSA-199977 | 1.1160194585e-13 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | ER to Golgi Anterograde Transport |
| GO:0048002 | 1.56114001217e-13 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | antigen processing and presentation of peptide antigen |
| REAC:R-HSA-948021 | 4.13161761613e-13 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | Transport to the Golgi and subsequent modification |
| GO:0019882 | 4.6974362025e-13 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | antigen processing and presentation |
| REAC:R-HSA-6811442 | 1.44058707716e-12 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-446203 | 2.87563095584e-11 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | Asparagine N-linked glycosylation |
| REAC:R-HSA-1280218 | 1.05483723791e-10 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | Adaptive Immune System |
| GO:0006888 | 1.9843061044e-10 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| REAC:R-HSA-2262752 | 5.08726464552e-10 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | Cellular responses to stress |
| KEGG:04962 | 6.89742368913e-10 | 0.555555555556 | DCTN2 DCTN5 DCTN6 DCTN4 DCTN1 | Vasopressin-regulated water reabsorption |
| GO:0005813 | 1.05139538287e-09 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | centrosome |
| REAC:R-HSA-8953897 | 2.18749081968e-09 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | Cellular responses to external stimuli |
| GO:0005875 | 7.22507601688e-09 | 0.777777777778 | DCTN3 ACTR1A DCTN2 DCTN4 ACTR1B DCTN1 ACTR10 | microtubule associated complex |
| REAC:R-HSA-199991 | 8.8620324609e-09 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | Membrane Trafficking |
| GO:0005815 | 1.27926012066e-08 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | microtubule organizing center |
| REAC:R-HSA-5653656 | 1.36160078985e-08 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | Vesicle-mediated transport |
| GO:0048193 | 2.41593638878e-08 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | Golgi vesicle transport |
| GO:0015630 | 7.16216154992e-07 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | microtubule cytoskeleton |
| REAC:R-HSA-168256 | 8.61086407311e-07 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | Immune System |
| REAC:R-HSA-597592 | 4.23715743072e-06 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | Post-translational protein modification |
| GO:0044430 | 6.40285487113e-06 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | cytoskeletal part |
| GO:0106006 | 7.62876038594e-06 | 0.333333333333 | ACTR1B ACTR10 ACTR1A | microtubule cortical anchor activity |
| GO:0030473 | 3.05058200216e-05 | 0.333333333333 | ACTR1B ACTR10 ACTR1A | nuclear migration along microtubule |
| GO:0046907 | 3.3037540428e-05 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | intracellular transport |
| GO:0000132 | 3.8665216288e-05 | 0.444444444444 | ACTR1B DCTN1 ACTR10 ACTR1A | establishment of mitotic spindle orientation |
| GO:0005856 | 4.45418003239e-05 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | cytoskeleton |
| GO:0016192 | 6.88978461682e-05 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | vesicle-mediated transport |
| GO:0040001 | 7.25177991479e-05 | 0.444444444444 | ACTR1B DCTN1 ACTR10 ACTR1A | establishment of mitotic spindle localization |
| REAC:R-HSA-392499 | 7.4753048218e-05 | 0.888888888889 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 DCTN1 DCTN4 | Metabolism of proteins |
| GO:0099738 | 9.60189204298e-05 | 0.444444444444 | ACTR1B DCTN1 ACTR10 ACTR1A | cell cortex region |
| GO:0051294 | 9.60189204298e-05 | 0.444444444444 | ACTR1B DCTN1 ACTR10 ACTR1A | establishment of spindle orientation |
| GO:1902850 | 0.000183750500382 | 0.555555555556 | ACTR1B DCTN1 ACTR10 ACTR1A DCTN2 | microtubule cytoskeleton organization involved in mitosis |
| GO:0051649 | 0.00021282459198 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | establishment of localization in cell |
| GO:0051293 | 0.000224830810977 | 0.444444444444 | ACTR1B DCTN1 ACTR10 ACTR1A | establishment of spindle localization |
| GO:0051653 | 0.000250458357857 | 0.444444444444 | ACTR1B DCTN1 ACTR10 ACTR1A | spindle localization |
| GO:0002376 | 0.000506781574075 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | immune system process |
| GO:0015629 | 0.00116435611083 | 0.666666666667 | DCTN3 ACTR1A DCTN2 DCTN4 ACTR1B ACTR10 | actin cytoskeleton |
| REAC:R-HSA-380284 | 0.00142807644904 | 0.333333333333 | DCTN3 ACTR1A DCTN2 | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-380259 | 0.00142807644904 | 0.333333333333 | DCTN3 ACTR1A DCTN2 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-8854518 | 0.0016303496753 | 0.333333333333 | DCTN3 ACTR1A DCTN2 | AURKA Activation by TPX2 |
| REAC:R-HSA-380270 | 0.00234883746975 | 0.333333333333 | DCTN3 ACTR1A DCTN2 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 0.00234883746975 | 0.333333333333 | DCTN3 ACTR1A DCTN2 | Centrosome maturation |
| GO:0051641 | 0.00248350783981 | 1.0 | DCTN3 ACTR1A DCTN2 DCTN6 ACTR10 DCTN5 ACTR1B DCTN1 DCTN4 | cellular localization |
| GO:0007097 | 0.00276765042703 | 0.333333333333 | ACTR1B ACTR10 ACTR1A | nuclear migration |
| GO:0008093 | 0.00276765042703 | 0.333333333333 | ACTR1B ACTR10 ACTR1A | cytoskeletal adaptor activity |
| REAC:R-HSA-2565942 | 0.00282588023244 | 0.333333333333 | DCTN3 ACTR1A DCTN2 | Regulation of PLK1 Activity at G2/M Transition |
| GO:0051647 | 0.00345851718181 | 0.333333333333 | ACTR1B ACTR10 ACTR1A | nucleus localization |
| REAC:R-HSA-380320 | 0.00347782665614 | 0.333333333333 | DCTN3 ACTR1A DCTN2 | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-5620912 | 0.004091371189 | 0.333333333333 | DCTN3 ACTR1A DCTN2 | Anchoring of the basal body to the plasma membrane |
| GO:0051640 | 0.00469219807311 | 0.666666666667 | DCTN3 ACTR1A DCTN2 ACTR1B DCTN1 ACTR10 | organelle localization |
| KEGG:05016 | 0.00661811550095 | 0.333333333333 | DCTN1 DCTN4 DCTN2 | Huntington disease |
| GO:0097711 | 0.00914929651627 | 0.444444444444 | DCTN3 DCTN2 ACTR1A DCTN1 | ciliary basal body-plasma membrane docking |
| GO:0030010 | 0.00954888715776 | 0.444444444444 | ACTR1B DCTN1 ACTR10 ACTR1A | establishment of cell polarity |
| REAC:R-HSA-69275 | 0.0323131842659 | 0.333333333333 | DCTN3 ACTR1A DCTN2 | G2/M Transition |
| REAC:R-HSA-5617833 | 0.032818837313 | 0.333333333333 | DCTN3 ACTR1A DCTN2 | Cilium Assembly |
| REAC:R-HSA-68877 | 0.032818837313 | 0.333333333333 | DCTN3 ACTR1A DCTN2 | Mitotic Prometaphase |
| REAC:R-HSA-453274 | 0.0333296326556 | 0.333333333333 | DCTN3 ACTR1A DCTN2 | Mitotic G2-G2/M phases |
| GO:0044448 | 0.041648880617 | 0.444444444444 | ACTR1B DCTN1 ACTR10 ACTR1A | cell cortex part |
| GO:1903047 | 0.0441048425129 | 0.666666666667 | DCTN3 ACTR1A DCTN2 ACTR1B DCTN1 ACTR10 | mitotic cell cycle process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DCTN3 | DCTN1 | 1.0 | 0.949 | hein_WMM bioplex (DCTN1) bioplex_WMM gupta (DCTN1) boldt (DCTN1) hein (DCTN1,DCTN3) boldt_WMM |
| DCTN3 | DCTN6 | 1.0 | 0.949 | hein_WMM bioplex (DCTN6) bioplex_WMM boldt hein (DCTN3) gupta_WMM boldt_WMM |
| DCTN1 | DCTN6 | 1.0 | 0.949 | hein_WMM bioplex (DCTN1,DCTN6) bioplex_WMM gupta (DCTN1) boldt (DCTN1) youn_WMM hein (DCTN1) boldt_WMM |
| ACTR10 | DCTN2 | 1.0 | 0.949 | hein_WMM bioplex (DCTN2) bioplex_WMM boldt (DCTN2) youn_WMM hein (DCTN2) gupta_WMM boldt_WMM |
| DCTN5 | DCTN6 | 1.0 | 0.949 | hein_WMM bioplex (DCTN6) bioplex_WMM Guru boldt youn_WMM hein (DCTN5) Malo gupta_WMM fraction boldt_WMM |
| DCTN4 | ACTR10 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (DCTN4) Malo gupta_WMM fraction boldt_WMM |
| DCTN4 | DCTN6 | 1.0 | 0.949 | hein_WMM bioplex (DCTN6) bioplex_WMM Guru boldt hein (DCTN4) Malo gupta_WMM fraction boldt_WMM |
| DCTN1 | ACTR1A | 1.0 | 0.949 | hein_WMM bioplex (DCTN1) bioplex_WMM Guru gupta (DCTN1) boldt (DCTN1) youn_WMM hein (DCTN1) Malo gupta_WMM fraction boldt_WMM |
| DCTN4 | ACTR1A | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (DCTN4) Malo gupta_WMM fraction boldt_WMM |
| DCTN4 | ACTR1B | 1.0 | 0.949 | hein_WMM bioplex (ACTR1B) bioplex_WMM Guru boldt hein (ACTR1B,DCTN4) Malo gupta_WMM fraction boldt_WMM |
| DCTN2 | ACTR1A | 1.0 | 0.949 | hein_WMM bioplex (DCTN2) bioplex_WMM Guru boldt (DCTN2) youn_WMM hein (DCTN2) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| DCTN4 | DCTN2 | 1.0 | 0.949 | hein_WMM bioplex (DCTN2) bioplex_WMM Guru boldt (DCTN2) youn_WMM hein (DCTN2,DCTN4) Malo gupta_WMM fraction boldt_WMM |
| DCTN6 | DCTN2 | 1.0 | 0.949 | hein_WMM bioplex (DCTN2,DCTN6) bioplex_WMM boldt (DCTN2) youn_WMM hein (DCTN2) gupta_WMM boldt_WMM |
| DCTN1 | ACTR10 | 1.0 | 0.949 | hein_WMM bioplex (DCTN1) bioplex_WMM gupta (DCTN1) boldt (DCTN1) youn_WMM hein (DCTN1) gupta_WMM boldt_WMM |
| DCTN1 | ACTR1B | 1.0 | 0.949 | hein_WMM bioplex (ACTR1B,DCTN1) bioplex_WMM Guru gupta (DCTN1) boldt youn_WMM hein (ACTR1B,DCTN1) Malo gupta_WMM fraction boldt_WMM |
| DCTN5 | ACTR1B | 1.0 | 0.949 | hein_WMM bioplex (ACTR1B) bioplex_WMM Guru boldt hein (ACTR1B,DCTN5) Malo gupta_WMM fraction boldt_WMM |
| DCTN3 | DCTN2 | 1.0 | 0.949 | hein_WMM bioplex (DCTN2) bioplex_WMM boldt (DCTN2) hein (DCTN2,DCTN3) gupta_WMM boldt_WMM |
| DCTN5 | DCTN2 | 1.0 | 0.949 | hein_WMM bioplex (DCTN2) bioplex_WMM Guru boldt (DCTN2) youn_WMM hein (DCTN2,DCTN5) Malo gupta_WMM fraction boldt_WMM |
| DCTN2 | ACTR1B | 1.0 | 0.949 | hein_WMM bioplex (ACTR1B,DCTN2) bioplex_WMM Guru boldt (DCTN2) youn_WMM hein (ACTR1B,DCTN2) Malo gupta_WMM fraction boldt_WMM |
| DCTN1 | DCTN2 | 1.0 | 0.949 | hein_WMM bioplex (DCTN1,DCTN2) bioplex_WMM Guru gupta (DCTN1) boldt (DCTN1,DCTN2) youn_WMM hein (DCTN1,DCTN2) Malo gupta_WMM fraction boldt_WMM |
| DCTN4 | DCTN1 | 1.0 | 0.949 | hein_WMM bioplex (DCTN1) bioplex_WMM Guru gupta (DCTN1) boldt (DCTN1) youn_WMM hein (DCTN1,DCTN4) Malo gupta_WMM fraction boldt_WMM |
| ACTR10 | ACTR1B | 1.0 | 0.949 | hein_WMM bioplex (ACTR1B) bioplex_WMM Guru boldt hein (ACTR1B) Malo gupta_WMM fraction boldt_WMM |
| DCTN6 | ACTR1B | 1.0 | 0.949 | hein_WMM bioplex (ACTR1B,DCTN6) bioplex_WMM boldt hein (ACTR1B) gupta_WMM boldt_WMM |
| DCTN5 | ACTR1A | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (DCTN5) Malo gupta_WMM fraction boldt_WMM |
| ACTR1A | ACTR1B | 1.0 | 0.949 | hein_WMM bioplex (ACTR1B) bioplex_WMM boldt youn_WMM hein (ACTR1B) gupta_WMM boldt_WMM |
| DCTN3 | ACTR1B | 1.0 | 0.949 | hein_WMM bioplex (ACTR1B) bioplex_WMM boldt hein (ACTR1B,DCTN3) gupta_WMM boldt_WMM |
| DCTN4 | DCTN5 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt hein (DCTN4,DCTN5) Malo gupta_WMM fraction boldt_WMM |
| ACTR10 | ACTR1A | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| DCTN5 | DCTN1 | 1.0 | 0.949 | hein_WMM bioplex (DCTN1) bioplex_WMM gupta (DCTN1) boldt youn_WMM hein (DCTN1,DCTN5) boldt_WMM |
| DCTN6 | ACTR10 | 1.0 | 0.949 | hein_WMM bioplex (DCTN6) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| DCTN4 | DCTN3 | 0.999 | 0.949 | hein_WMM bioplex_WMM boldt hein (DCTN3,DCTN4) gupta_WMM boldt_WMM |
| DCTN5 | ACTR10 | 0.998 | 0.939 | hein_WMM bioplex_WMM boldt youn_WMM hein (DCTN5) gupta_WMM boldt_WMM |
| DCTN5 | DCTN3 | 0.995 | 0.924 | hein_WMM bioplex_WMM boldt hein (DCTN3,DCTN5) gupta_WMM boldt_WMM |
| DCTN3 | ACTR10 | 0.994 | 0.919 | hein_WMM bioplex_WMM boldt hein (DCTN3) gupta_WMM boldt_WMM |
| DCTN6 | ACTR1A | 0.992 | 0.911 | hein_WMM bioplex (DCTN6) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| DCTN3 | ACTR1A | 0.973 | 0.886 | hein_WMM bioplex_WMM boldt hein (DCTN3) gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_04207 has an average edge precision of 0.944 which is ranked 367 out of all 6965 complexes.
Related Complexes