hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04213
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GTF2H2C | General transcription factor IIH subunit 2-like protein (General transcription factor IIH polypeptide 2-like protein) | UniProt NCBI |
| GTF2H2C | General transcription factor IIH subunit 2-like protein (General transcription factor IIH polypeptide 2-like protein) | UniProt NCBI |
| ERCC3 | General transcription and DNA repair factor IIH helicase subunit XPB (TFIIH subunit XPB) (EC 3.6.4.12) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) | UniProt NCBI |
| GTF2H5 | General transcription factor IIH subunit 5 (General transcription factor IIH polypeptide 5) (TFB5 ortholog) (TFIIH basal transcription factor complex TTD-A subunit) | UniProt NCBI |
| GTF2H1 | General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit) | UniProt NCBI |
| GTF2H2 | General transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit) | UniProt NCBI |
| RNF135 | E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING-type E3 ubiquitin transferase RNF135) (Riplet) | UniProt NCBI |
| GTF2H3 | General transcription factor IIH subunit 3 (Basic transcription factor 2 34 kDa subunit) (BTF2 p34) (General transcription factor IIH polypeptide 3) (TFIIH basal transcription factor complex p34 subunit) | UniProt NCBI |
| GTF2H4 | General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit) | UniProt NCBI |
| PTS | 6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005675 | 4.42288756464e-17 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | transcription factor TFIIH holo complex |
| CORUM:1029 | 4.80933423546e-17 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | TFIIH transcription factor complex |
| CORUM:1009 | 4.80933423546e-17 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | TFIIH transcription factor complex |
| GO:0000439 | 2.77300804133e-16 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | transcription factor TFIIH core complex |
| CORUM:1037 | 8.53043734036e-16 | 0.555555555556 | GTF2H1 ERCC3 GTF2H3 GTF2H4 GTF2H2 | TFIIH transcription factor core complex |
| GO:0032806 | 2.81157896746e-15 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | carboxy-terminal domain protein kinase complex |
| CORUM:1036 | 1.07387282252e-13 | 0.555555555556 | GTF2H1 ERCC3 GTF2H3 GTF2H4 GTF2H2 | TFIIH transcription factor complex |
| CORUM:107 | 1.07387282252e-13 | 0.555555555556 | GTF2H1 ERCC3 GTF2H3 GTF2H4 GTF2H2 | TFIIH transcription factor complex |
| REAC:R-HSA-167160 | 3.258423751e-13 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| REAC:R-HSA-77075 | 3.258423751e-13 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Pol II CTD phosphorylation and interaction with CE |
| REAC:R-HSA-72086 | 5.22712472345e-13 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | mRNA Capping |
| REAC:R-HSA-73863 | 8.09924118979e-13 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase I Transcription Termination |
| REAC:R-HSA-167158 | 1.21792597466e-12 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-113418 | 1.21792597466e-12 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Formation of the Early Elongation Complex |
| KEGG:03022 | 1.47966673573e-12 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Basal transcription factors |
| KEGG:03420 | 1.99044134942e-12 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Nucleotide excision repair |
| REAC:R-HSA-5696400 | 4.93756840476e-12 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 6.69231412863e-12 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Formation of Incision Complex in GG-NER |
| REAC:R-HSA-167169 | 7.74765417683e-12 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | HIV Transcription Elongation |
| REAC:R-HSA-167246 | 7.74765417683e-12 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167200 | 7.74765417683e-12 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167152 | 1.02769825955e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-167162 | 1.17788919867e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase II HIV Promoter Escape |
| REAC:R-HSA-73776 | 1.17788919867e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase II Promoter Escape |
| REAC:R-HSA-75953 | 1.17788919867e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase II Transcription Initiation |
| REAC:R-HSA-76042 | 1.17788919867e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| REAC:R-HSA-73762 | 1.17788919867e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase I Transcription Initiation |
| REAC:R-HSA-73779 | 1.17788919867e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| REAC:R-HSA-167161 | 1.17788919867e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | HIV Transcription Initiation |
| GO:0006293 | 1.50084983767e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | nucleotide-excision repair, preincision complex stabilization |
| GO:0006295 | 1.50084983767e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | nucleotide-excision repair, DNA incision, 3'-to lesion |
| GO:0000717 | 2.06331179847e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | nucleotide-excision repair, DNA duplex unwinding |
| REAC:R-HSA-6781823 | 2.51577234899e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Formation of TC-NER Pre-Incision Complex |
| CORUM:103 | 3.61037807908e-11 | 0.555555555556 | GTF2H1 ERCC3 GTF2H3 GTF2H4 GTF2H2 | RNA polymerase II holoenzyme complex |
| REAC:R-HSA-112382 | 4.93244931022e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-75955 | 4.93244931022e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase II Transcription Elongation |
| CORUM:2825 | 5.5849858239e-11 | 0.555555555556 | GTF2H1 ERCC3 GTF2H3 GTF2H4 GTF2H2 | BRCA1-RNA polymerase II complex |
| GO:0070911 | 6.36226734931e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | global genome nucleotide-excision repair |
| REAC:R-HSA-6796648 | 6.7261292078e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | TP53 Regulates Transcription of DNA Repair Genes |
| GO:0016591 | 8.16857615821e-11 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | RNA polymerase II, holoenzyme |
| REAC:R-HSA-6782210 | 8.20034977029e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 9.03271825157e-11 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Dual incision in TC-NER |
| GO:1902554 | 9.97653441818e-11 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | serine/threonine protein kinase complex |
| GO:0006294 | 1.31200830559e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | nucleotide-excision repair, preincision complex assembly |
| GO:0006362 | 1.31200830559e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | transcription elongation from RNA polymerase I promoter |
| REAC:R-HSA-167172 | 1.56456389821e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Transcription of the HIV genome |
| GO:0006363 | 2.03290953864e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | termination of RNA polymerase I transcription |
| GO:0009452 | 2.50160976396e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | 7-methylguanosine RNA capping |
| GO:0006361 | 2.50160976396e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | transcription initiation from RNA polymerase I promoter |
| GO:0006370 | 2.50160976396e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | 7-methylguanosine mRNA capping |
| REAC:R-HSA-6781827 | 2.8025143252e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| GO:0036260 | 3.05699419639e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA capping |
| GO:1902911 | 3.51358887621e-10 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | protein kinase complex |
| REAC:R-HSA-674695 | 3.81797486899e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase II Pre-transcription Events |
| REAC:R-HSA-5696399 | 4.43051739548e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| GO:0006296 | 6.41218851534e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| GO:0055029 | 6.59063608908e-10 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | nuclear DNA-directed RNA polymerase complex |
| REAC:R-HSA-73772 | 6.77923713987e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase I Promoter Escape |
| GO:0000428 | 7.10240179596e-10 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | DNA-directed RNA polymerase complex |
| GO:0030880 | 8.84708832869e-10 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | RNA polymerase complex |
| GO:0033683 | 8.99580995724e-10 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | nucleotide-excision repair, DNA incision |
| WP:WP405 | 9.18922602235e-10 | 0.555555555556 | GTF2H1 ERCC3 GTF2H3 GTF2H4 GTF2H2 | Eukaryotic Transcription Initiation |
| GO:0006289 | 1.25720061011e-09 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | nucleotide-excision repair |
| REAC:R-HSA-427413 | 1.74775069694e-09 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | NoRC negatively regulates rRNA expression |
| REAC:R-HSA-5250941 | 2.07704084707e-09 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 2.19765172945e-09 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-5696398 | 2.3240355624e-09 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Nucleotide Excision Repair |
| REAC:R-HSA-73864 | 2.3240355624e-09 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase I Transcription |
| GO:0032508 | 5.60069931332e-09 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | DNA duplex unwinding |
| REAC:R-HSA-162599 | 7.41010534477e-09 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Late Phase of HIV Life Cycle |
| GO:0008353 | 8.81803084449e-09 | 0.555555555556 | GTF2H1 ERCC3 GTF2H3 GTF2H4 GTF2H2 | RNA polymerase II CTD heptapeptide repeat kinase activity |
| GO:0006360 | 1.23804477687e-08 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | transcription by RNA polymerase I |
| REAC:R-HSA-212165 | 1.307160447e-08 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Epigenetic regulation of gene expression |
| REAC:R-HSA-162587 | 1.307160447e-08 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | HIV Life Cycle |
| GO:0090575 | 1.33270862292e-08 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | RNA polymerase II transcription factor complex |
| GO:0032392 | 1.68825843116e-08 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | DNA geometric change |
| GO:0006283 | 4.66608951843e-08 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | transcription-coupled nucleotide-excision repair |
| GO:0006353 | 4.66608951843e-08 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | DNA-templated transcription, termination |
| GO:0044798 | 4.83815845837e-08 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | nuclear transcription factor complex |
| GO:0006368 | 7.61115344513e-08 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-162906 | 1.6980163507e-07 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | HIV Infection |
| GO:0061695 | 2.69489307106e-07 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | transferase complex, transferring phosphorus-containing groups |
| GO:0005669 | 2.85350879493e-07 | 0.555555555556 | GTF2H5 GTF2H2 GTF2H3 ERCC3 GTF2H4 | transcription factor TFIID complex |
| GO:0006354 | 4.38685424933e-07 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | DNA-templated transcription, elongation |
| GO:0005667 | 6.57111131446e-07 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | transcription factor complex |
| GO:0070816 | 1.01246124774e-06 | 0.444444444444 | GTF2H5 GTF2H1 GTF2H3 GTF2H4 | phosphorylation of RNA polymerase II C-terminal domain |
| GO:0090305 | 1.47250547126e-06 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | nucleic acid phosphodiester bond hydrolysis |
| REAC:R-HSA-73894 | 1.51609607484e-06 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | DNA Repair |
| REAC:R-HSA-3700989 | 2.45867589224e-06 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Transcriptional Regulation by TP53 |
| REAC:R-HSA-5663205 | 2.91264524423e-06 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Infectious disease |
| GO:0000438 | 7.62876038594e-06 | 0.333333333333 | GTF2H2 GTF2H3 GTF2H4 | core TFIIH complex portion of holo TFIIH complex |
| GO:0006367 | 8.26444333818e-06 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | transcription initiation from RNA polymerase II promoter |
| GO:0031334 | 1.37907325408e-05 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | positive regulation of protein complex assembly |
| GO:0065004 | 1.5695852077e-05 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | protein-DNA complex assembly |
| GO:0006352 | 2.88227833807e-05 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | DNA-templated transcription, initiation |
| GO:0006281 | 4.05108332273e-05 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | DNA repair |
| GO:0008094 | 4.97784376708e-05 | 0.555555555556 | GTF2H1 ERCC3 GTF2H3 GTF2H4 GTF2H2 | DNA-dependent ATPase activity |
| GO:0071103 | 5.69694250228e-05 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | DNA conformation change |
| GO:0071824 | 5.99661869745e-05 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | protein-DNA complex subunit organization |
| REAC:R-HSA-8953854 | 0.000102817629694 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Metabolism of RNA |
| KEGG:05203 | 0.000150904338914 | 0.444444444444 | GTF2H1 GTF2H3 GTF2H4 GTF2H2 | Viral carcinogenesis |
| GO:0043254 | 0.000327131288655 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | regulation of protein complex assembly |
| GO:1990234 | 0.000807239088 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | transferase complex |
| GO:0044089 | 0.00080744957367 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | positive regulation of cellular component biogenesis |
| GO:0006259 | 0.000908515472699 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | DNA metabolic process |
| GO:0006974 | 0.000917423760089 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | cellular response to DNA damage stimulus |
| REAC:R-HSA-1643685 | 0.000933302100755 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Disease |
| CORUM:3066 | 0.00104260750106 | 0.222222222222 | ERCC3 GTF2H3 | RNA polymerase II complex, chromatin structure modifying |
| GO:0006397 | 0.00137640098394 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | mRNA processing |
| CORUM:1141 | 0.00140263049425 | 0.222222222222 | ERCC3 GTF2H4 | CF IIAm complex (Cleavage factor IIAm complex) |
| REAC:R-HSA-212436 | 0.00153947562646 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Generic Transcription Pathway |
| GO:0016251 | 0.00217524004777 | 0.333333333333 | GTF2H2 GTF2H3 GTF2H4 | RNA polymerase II general transcription initiation factor activity |
| REAC:R-HSA-73857 | 0.00289990133995 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | RNA Polymerase II Transcription |
| GO:0042623 | 0.00327431098328 | 0.555555555556 | GTF2H1 ERCC3 GTF2H3 GTF2H4 GTF2H2 | ATPase activity, coupled |
| HP:0045055 | 0.00337693930593 | 0.222222222222 | ERCC3 GTF2H5 | Tiger tail banding |
| HP:0007381 | 0.00337693930593 | 0.222222222222 | ERCC3 GTF2H5 | Congenital exfoliative erythroderma |
| HP:0410219 | 0.00337693930593 | 0.222222222222 | ERCC3 GTF2H5 | Hypoplasia of mandible relative to maxilla |
| HP:0012760 | 0.00337693930593 | 0.222222222222 | ERCC3 GTF2H5 | Impaired social reciprocity |
| HP:0002562 | 0.00472623345058 | 0.222222222222 | ERCC3 GTF2H5 | Low-set nipples |
| GO:0044451 | 0.00537320209692 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | nucleoplasm part |
| REAC:R-HSA-74160 | 0.00545442724115 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | Gene expression (Transcription) |
| GO:0140223 | 0.00619690362803 | 0.333333333333 | GTF2H2 GTF2H3 GTF2H4 | general transcription initiation factor activity |
| HP:0007587 | 0.00629966976086 | 0.222222222222 | ERCC3 GTF2H5 | Numerous pigmented freckles |
| HP:0001809 | 0.00629966976086 | 0.222222222222 | ERCC3 GTF2H5 | Split nail |
| HP:0006538 | 0.00809703709436 | 0.222222222222 | ERCC3 GTF2H5 | Recurrent bronchopulmonary infections |
| HP:0025428 | 0.00809703709436 | 0.222222222222 | ERCC3 GTF2H5 | Bronchospasm |
| HP:0007034 | 0.00809703709436 | 0.222222222222 | ERCC3 GTF2H5 | Generalized hyperreflexia |
| HP:0025356 | 0.00985133247699 | 0.333333333333 | ERCC3 GTF2H5 PTS | Psychomotor retardation |
| HP:0025427 | 0.0101181244364 | 0.222222222222 | ERCC3 GTF2H5 | Abnormal bronchus physiology |
| HP:0007485 | 0.0123627209 | 0.222222222222 | ERCC3 GTF2H5 | Absence of subcutaneous fat |
| HP:0001598 | 0.0123627209 | 0.222222222222 | ERCC3 GTF2H5 | Concave nail |
| HP:0000320 | 0.0148306157257 | 0.222222222222 | ERCC3 GTF2H5 | Bird-like facies |
| HP:0003079 | 0.0148306157257 | 0.222222222222 | ERCC3 GTF2H5 | Defective DNA repair after ultraviolet radiation damage |
| HP:0100275 | 0.0148306157257 | 0.222222222222 | ERCC3 GTF2H5 | Diffuse cerebellar atrophy |
| HP:0007266 | 0.0148306157257 | 0.222222222222 | ERCC3 GTF2H5 | Cerebral dysmyelination |
| HP:0007479 | 0.0175215982818 | 0.222222222222 | ERCC3 GTF2H5 | Congenital nonbullous ichthyosiform erythroderma |
| HP:0025548 | 0.0175215982818 | 0.222222222222 | ERCC3 GTF2H5 | Increased mean corpuscular hemoglobin concentration |
| HP:0003254 | 0.0235719846951 | 0.222222222222 | ERCC3 GTF2H5 | Abnormality of DNA repair |
| GO:0016887 | 0.0237159134845 | 0.555555555556 | GTF2H1 ERCC3 GTF2H3 GTF2H4 GTF2H2 | ATPase activity |
| HP:0007633 | 0.026930967926 | 0.222222222222 | ERCC3 GTF2H5 | Bilateral microphthalmos |
| HP:0025546 | 0.026930967926 | 0.222222222222 | ERCC3 GTF2H5 | Abnormal mean corpuscular hemoglobin concentration |
| GO:0044087 | 0.027983438536 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | regulation of cellular component biogenesis |
| HP:0003139 | 0.0305121976344 | 0.222222222222 | ERCC3 GTF2H5 | Panhypogammaglobulinemia |
| GO:1902494 | 0.0328019970767 | 0.777777777778 | GTF2H5 GTF2H2C ERCC3 GTF2H2 GTF2H2C GTF2H1 GTF2H4 GTF2H3 | catalytic complex |
| HP:0006970 | 0.0343154638255 | 0.222222222222 | ERCC3 GTF2H5 | Periventricular leukomalacia |
| GO:0016071 | 0.0437420746277 | 0.666666666667 | GTF2H5 GTF2H2 ERCC3 GTF2H1 GTF2H4 GTF2H3 | mRNA metabolic process |
| HP:0001807 | 0.0470553832537 | 0.222222222222 | ERCC3 GTF2H5 | Ridged nail |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GTF2H2C | GTF2H2C | 1.0 | 0.949 | bioplex (GTF2H2C;) bioplex_WMM |
| GTF2H2C | GTF2H1 | 1.0 | 0.949 | bioplex (GTF2H2C;) bioplex_WMM Malo fraction |
| GTF2H1 | ERCC3 | 1.0 | 0.949 | hein_WMM bioplex (ERCC3) bioplex_WMM Malo fraction |
| GTF2H1 | GTF2H3 | 1.0 | 0.949 | hein_WMM bioplex (GTF2H3) bioplex_WMM Malo fraction |
| GTF2H2C | ERCC3 | 1.0 | 0.949 | bioplex (GTF2H2C;) bioplex_WMM Malo fraction |
| GTF2H4 | ERCC3 | 1.0 | 0.949 | hein_WMM bioplex (ERCC3) bioplex_WMM Malo fraction |
| GTF2H2C | GTF2H3 | 0.998 | 0.939 | bioplex (GTF2H2C;) bioplex_WMM Malo fraction |
| GTF2H1 | GTF2H4 | 0.998 | 0.936 | hein_WMM bioplex_WMM Malo fraction |
| GTF2H2 | ERCC3 | 0.989 | 0.905 | hein_WMM bioplex (ERCC3) bioplex_WMM Malo fraction |
| GTF2H5 | GTF2H3 | 0.986 | 0.901 | hein_WMM bioplex (GTF2H3,GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H5 | GTF2H4 | 0.983 | 0.898 | hein_WMM bioplex (GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H5 | GTF2H1 | 0.98 | 0.896 | hein_WMM bioplex (GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H1 | GTF2H2 | 0.964 | 0.872 | hein_WMM bioplex_WMM Malo fraction |
| GTF2H3 | GTF2H2 | 0.962 | 0.87 | hein_WMM bioplex (GTF2H3) bioplex_WMM Malo fraction |
| GTF2H5 | ERCC3 | 0.951 | 0.858 | hein_WMM bioplex (ERCC3,GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H3 | ERCC3 | 0.945 | 0.856 | hein_WMM bioplex (ERCC3,GTF2H3) bioplex_WMM Malo fraction |
| GTF2H3 | GTF2H4 | 0.93 | 0.846 | hein_WMM bioplex (GTF2H3) bioplex_WMM Malo fraction |
| GTF2H2 | GTF2H4 | 0.823 | 0.774 | hein_WMM bioplex_WMM Malo fraction |
| GTF2H5 | GTF2H2 | 0.747 | 0.741 | hein_WMM bioplex (GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H2C | GTF2H5 | 0.529 | 0.634 | bioplex (GTF2H2C;) bioplex_WMM |
| GTF2H2C | PTS | 0.221 | 0.466 | bioplex (GTF2H2C;) bioplex_WMM |
| GTF2H2C | GTF2H4 | 0.213 | 0.464 | bioplex (GTF2H2C;) bioplex_WMM Malo fraction |
| GTF2H2 | RNF135 | 0.021 | 0.19 | bioplex (RNF135) bioplex_WMM |
| GTF2H2C | GTF2H4 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| GTF2H2C | GTF2H5 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| GTF2H2C | PTS | 0.009 | 0.101 | bioplex_WMM WMM_only |
| GTF2H2C | GTF2H3 | 0.009 | 0.09 | bioplex_WMM youn_WMM WMM_only |
| GTF2H2C | GTF2H1 | 0.009 | 0.089 | bioplex_WMM WMM_only |
| GTF2H2C | ERCC3 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| PTS | GTF2H5 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| PTS | GTF2H4 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| PTS | GTF2H3 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| PTS | GTF2H1 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| PTS | ERCC3 | 0.008 | 0.067 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_04213 has an average edge precision of 0.581 which is ranked 2029 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GTF2H2C | HuMAP2_01329 HuMAP2_01999 HuMAP2_04213 HuMAP2_05362 HuMAP2_06159 |
| GTF2H2C | HuMAP2_01329 HuMAP2_04213 HuMAP2_05362 HuMAP2_06159 |
| ERCC3 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 HuMAP2_06407 |
| GTF2H5 | HuMAP2_01967 HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| GTF2H1 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| GTF2H2 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| RNF135 | HuMAP2_04213 |
| GTF2H3 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| GTF2H4 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| PTS | HuMAP2_01329 HuMAP2_04213 HuMAP2_06159 |