hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04225
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| METRN | Meteorin | UniProt NCBI |
| HAPLN3 | Hyaluronan and proteoglycan link protein 3 | UniProt NCBI |
| ZFPM1 | Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1) | UniProt NCBI |
| A2M | Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5) | UniProt NCBI |
| GPX3 | Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P) | UniProt NCBI |
| LOXL1 | Lysyl oxidase homolog 1 (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL) | UniProt NCBI |
| DEFA6 | Defensin-6 (Defensin, alpha 6) | UniProt NCBI |
| DEFA5 | Defensin-5 (Defensin, alpha 5) (HD5(20-94)) [Cleaved into: HD5(23-94); HD5(29-94); HD5(56-94); HD5(63-94)] | UniProt NCBI |
| METRNL | Meteorin-like protein (Subfatin) | UniProt NCBI |
| CHAC2 | Glutathione-specific gamma-glutamylcyclotransferase 2 (Gamma-GCG 2) (EC 4.3.2.7) (Cation transport regulator-like protein 2) | UniProt NCBI |
| PZP | NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1462054 | 0.00237162331405 | 0.2 | DEFA6 DEFA5 | Alpha-defensins |
| REAC:R-HSA-1461973 | 0.0144268822495 | 0.2 | DEFA6 DEFA5 | Defensins |
| KEGG:00480 | 0.02255695928 | 0.2 | GPX3 CHAC2 | Glutathione metabolism |
| KEGG:05150 | 0.0408935839079 | 0.2 | DEFA6 DEFA5 | Staphylococcus aureus infection |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| A2M | PZP | 1.0 | 0.949 | bioplex (A2M) bioplex_WMM boldt_WMM |
| ZFPM1 | DEFA6 | 0.161 | 0.417 | bioplex (DEFA6) bioplex_WMM |
| METRN | A2M | 0.125 | 0.399 | bioplex (A2M) bioplex_WMM |
| DEFA6 | PZP | 0.112 | 0.381 | bioplex (DEFA6) bioplex_WMM |
| METRNL | A2M | 0.111 | 0.378 | bioplex (A2M) bioplex_WMM |
| GPX3 | A2M | 0.104 | 0.366 | bioplex (A2M) bioplex_WMM |
| HAPLN3 | A2M | 0.092 | 0.356 | bioplex (A2M) bioplex_WMM |
| METRNL | DEFA5 | 0.087 | 0.352 | bioplex (DEFA5) bioplex_WMM |
| HAPLN3 | CHAC2 | 0.028 | 0.23 | bioplex (HAPLN3) bioplex_WMM |
| LOXL1 | A2M | 0.021 | 0.187 | bioplex (A2M) bioplex_WMM |
| METRN | DEFA5 | 0.021 | 0.187 | bioplex (DEFA5) bioplex_WMM |
| METRN | METRNL | 0.01 | 0.128 | bioplex_WMM WMM_only |
| METRN | HAPLN3 | 0.009 | 0.092 | bioplex_WMM WMM_only |
| GPX3 | PZP | 0.008 | 0.091 | bioplex_WMM WMM_only |
| METRNL | GPX3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| METRN | GPX3 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| METRNL | PZP | 0.008 | 0.085 | bioplex_WMM WMM_only |
| GPX3 | LOXL1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| ZFPM1 | PZP | 0.008 | 0.067 | bioplex_WMM WMM_only |
| METRN | PZP | 0.008 | 0.067 | bioplex_WMM WMM_only |
| METRNL | LOXL1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| LOXL1 | PZP | 0.008 | 0.06 | bioplex_WMM WMM_only |
| HAPLN3 | GPX3 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| METRN | LOXL1 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| HAPLN3 | PZP | 0.008 | 0.029 | bioplex_WMM WMM_only |
| HAPLN3 | METRNL | 0.008 | 0.029 | bioplex_WMM WMM_only |
| HAPLN3 | LOXL1 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| ZFPM1 | A2M | 0.007 | 0.007 | bioplex_WMM WMM_only |
| DEFA6 | A2M | 0.006 | 0.007 | bioplex (DEFA6) bioplex_WMM |
| A2M | DEFA5 | 0.005 | 0.006 | bioplex (DEFA5) bioplex_WMM |
Images
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Complex HuMAP2_04225 has an average edge precision of 0.176 which is ranked 6461 out of all 6965 complexes.
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