hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04235
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| APTX | Aprataxin (EC 3.1.11.7) (EC 3.1.12.2) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | UniProt NCBI |
| IFFO1 | Intermediate filament family orphan 1 (Tumor antigen HOM-TES-103) | UniProt NCBI |
| IFFO2 | Intermediate filament family orphan 2 | UniProt NCBI |
| XRCC4 | DNA repair protein XRCC4 (X-ray repair cross-complementing protein 4) | UniProt NCBI |
| LIG4 | DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:344 | 6.70868171695e-06 | 0.4 | XRCC4 LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:348 | 6.70868171695e-06 | 0.4 | XRCC4 LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:345 | 6.70868171695e-06 | 0.4 | XRCC4 LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:352 | 6.70868171695e-06 | 0.4 | XRCC4 LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:206 | 6.70868171695e-06 | 0.4 | XRCC4 LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:354 | 6.70868171695e-06 | 0.4 | XRCC4 LIG4 | DNA ligase IV-XRCC4 complex |
| CORUM:359 | 2.0123342217e-05 | 0.4 | XRCC4 LIG4 | DNA ligase IV-XRCC4-XLF complex |
| CORUM:336 | 2.0123342217e-05 | 0.4 | XRCC4 LIG4 | DNA ligase IV-XRCC4-AHNK complex |
| CORUM:350 | 2.0123342217e-05 | 0.4 | XRCC4 LIG4 | DNA ligase IV-XRCC4-PNK complex |
| CORUM:1189 | 0.000140787732431 | 0.4 | XRCC4 LIG4 | DNA double-strand break end-joining complex |
| REAC:R-HSA-164843 | 0.000283261545489 | 0.4 | XRCC4 LIG4 | 2-LTR circle formation |
| KEGG:03450 | 0.000334402895448 | 0.4 | XRCC4 LIG4 | Non-homologous end-joining |
| REAC:R-HSA-162592 | 0.000485460775426 | 0.4 | XRCC4 LIG4 | Integration of provirus |
| REAC:R-HSA-162594 | 0.00122631290825 | 0.4 | XRCC4 LIG4 | Early Phase of HIV Life Cycle |
| HP:0000320 | 0.0030633405246 | 0.4 | XRCC4 LIG4 | Bird-like facies |
| HP:0003683 | 0.00361982515692 | 0.4 | XRCC4 LIG4 | Large beaked nose |
| HP:0004430 | 0.00487153229182 | 0.4 | XRCC4 LIG4 | Severe combined immunodeficiency |
| HP:0005387 | 0.00630809873773 | 0.4 | XRCC4 LIG4 | Combined immunodeficiency |
| GO:0032807 | 0.0135228859698 | 0.4 | XRCC4 LIG4 | DNA ligase IV complex |
| GO:0033152 | 0.0270421395626 | 0.4 | XRCC4 LIG4 | immunoglobulin V(D)J recombination |
| GO:0005958 | 0.0270421395626 | 0.4 | XRCC4 LIG4 | DNA-dependent protein kinase-DNA ligase 4 complex |
| REAC:R-HSA-5693571 | 0.0313816354582 | 0.4 | XRCC4 LIG4 | Nonhomologous End-Joining (NHEJ) |
| HP:0003220 | 0.0325153883173 | 0.4 | XRCC4 LIG4 | Abnormality of chromosome stability |
| CORUM:213 | 0.0499494897235 | 0.2 | LIG4 | DNA ligase IV-XRCC1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC4 | LIG4 | 1.0 | 0.949 | hein_WMM bioplex (XRCC4) bioplex_WMM |
| APTX | XRCC4 | 1.0 | 0.949 | bioplex (XRCC4) bioplex_WMM |
| XRCC4 | IFFO1 | 0.599 | 0.669 | bioplex (XRCC4) bioplex_WMM |
| XRCC4 | IFFO2 | 0.469 | 0.605 | bioplex (XRCC4) bioplex_WMM |
| IFFO1 | IFFO2 | 0.009 | 0.11 | bioplex_WMM WMM_only |
| LIG4 | IFFO2 | 0.009 | 0.109 | bioplex_WMM WMM_only |
| APTX | LIG4 | 0.009 | 0.093 | bioplex_WMM WMM_only |
| APTX | IFFO2 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| LIG4 | IFFO1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| APTX | IFFO1 | 0.008 | 0.037 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04235 has an average edge precision of 0.37 which is ranked 3637 out of all 6965 complexes.
Related Complexes