hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04238
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PLOD1 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1) | UniProt NCBI |
| COL4A2 | Collagen alpha-2(IV) chain [Cleaved into: Canstatin] | UniProt NCBI |
| COL4A5 | Collagen alpha-5(IV) chain | UniProt NCBI |
| COL4A6 | Collagen alpha-6(IV) chain | UniProt NCBI |
| COL4A1 | Collagen alpha-1(IV) chain [Cleaved into: Arresten] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1650814 | 1.58712520861e-10 | 1.0 | COL4A6 PLOD1 COL4A1 COL4A2 COL4A5 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-2214320 | 4.98207499369e-10 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Anchoring fibril formation |
| REAC:R-HSA-1474290 | 7.57189610424e-10 | 1.0 | COL4A6 PLOD1 COL4A1 COL4A2 COL4A5 | Collagen formation |
| REAC:R-HSA-2243919 | 1.11668064351e-09 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Crosslinking of collagen fibrils |
| GO:0005587 | 1.82947049513e-09 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | collagen type IV trimer |
| GO:0098642 | 1.82947049513e-09 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | network-forming collagen trimer |
| GO:0098645 | 1.82947049513e-09 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | collagen network |
| GO:0098651 | 4.26853511465e-09 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | basement membrane collagen trimer |
| REAC:R-HSA-3000157 | 9.99440778064e-09 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Laminin interactions |
| REAC:R-HSA-8948216 | 2.99818273785e-08 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Collagen chain trimerization |
| REAC:R-HSA-2022090 | 1.33760664717e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Assembly of collagen fibrils and other multimeric structures |
| KEGG:04974 | 1.40659404296e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Protein digestion and absorption |
| REAC:R-HSA-3000171 | 1.43848058581e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Non-integrin membrane-ECM interactions |
| KEGG:04512 | 1.65048029426e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | ECM-receptor interaction |
| REAC:R-HSA-1442490 | 1.77549959727e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Collagen degradation |
| KEGG:05146 | 2.34194288389e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Amoebiasis |
| REAC:R-HSA-3000178 | 2.6233234194e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | ECM proteoglycans |
| REAC:R-HSA-1474244 | 2.67089525702e-07 | 1.0 | COL4A6 PLOD1 COL4A1 COL4A2 COL4A5 | Extracellular matrix organization |
| WP:WP4658 | 2.86239450815e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Small cell lung cancer |
| KEGG:04933 | 3.09031028687e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05222 | 3.23060453996e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Small cell lung cancer |
| GO:0098644 | 3.72971334932e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | complex of collagen trimers |
| REAC:R-HSA-216083 | 4.42192738057e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Integrin cell surface interactions |
| KEGG:04926 | 9.48333739363e-07 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Relaxin signaling pathway |
| WP:WP4239 | 1.18722341911e-06 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Epithelial to mesenchymal transition in colorectal cancer |
| GO:0005581 | 3.33813219873e-06 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | collagen trimer |
| REAC:R-HSA-1474228 | 3.87002996107e-06 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Degradation of the extracellular matrix |
| KEGG:04510 | 5.92265169136e-06 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Focal adhesion |
| GO:0030020 | 7.17274954203e-06 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | extracellular matrix structural constituent conferring tensile strength |
| GO:0044420 | 8.04174090024e-06 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | extracellular matrix component |
| REAC:R-HSA-419037 | 1.34474619847e-05 | 0.6 | COL4A1 COL4A2 COL4A5 | NCAM1 interactions |
| GO:0005604 | 2.17063078318e-05 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | basement membrane |
| WP:WP4172 | 2.46316127093e-05 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | PI3K-Akt Signaling Pathway |
| KEGG:04151 | 3.78166640446e-05 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | PI3K-Akt signaling pathway |
| KEGG:05165 | 4.42454478418e-05 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Human papillomavirus infection |
| REAC:R-HSA-375165 | 5.30427262701e-05 | 0.6 | COL4A1 COL4A2 COL4A5 | NCAM signaling for neurite out-growth |
| REAC:R-HSA-186797 | 6.70990066737e-05 | 0.6 | COL4A1 COL4A2 COL4A5 | Signaling by PDGF |
| GO:0030198 | 6.80047135479e-05 | 1.0 | COL4A6 PLOD1 COL4A1 COL4A2 COL4A5 | extracellular matrix organization |
| MIRNA:hsa-miR-29b-3p | 0.000100661483632 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | hsa-miR-29b-3p |
| GO:0043062 | 0.000142444005625 | 1.0 | COL4A6 PLOD1 COL4A1 COL4A2 COL4A5 | extracellular structure organization |
| KEGG:05200 | 0.000217862252065 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | Pathways in cancer |
| WP:WP2911 | 0.000699493021643 | 0.4 | COL4A1 COL4A2 | miRNA targets in ECM and membrane receptors |
| WP:WP306 | 0.000719570270021 | 0.6 | COL4A6 COL4A2 COL4A1 | Focal Adhesion |
| GO:0005201 | 0.001292590007 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | extracellular matrix structural constituent |
| WP:WP3932 | 0.00181204447901 | 0.6 | COL4A6 COL4A2 COL4A1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| REAC:R-HSA-3000480 | 0.00183199274719 | 0.4 | COL4A1 COL4A2 | Scavenging by Class A Receptors |
| REAC:R-HSA-2173782 | 0.00799559968784 | 0.4 | COL4A1 COL4A2 | Binding and Uptake of Ligands by Scavenger Receptors |
| HP:0002132 | 0.0138999712057 | 0.4 | COL4A1 COL4A2 | Porencephalic cyst |
| HP:0011029 | 0.0147605976923 | 0.6 | PLOD1 COL4A2 COL4A1 | Internal hemorrhage |
| HP:0002301 | 0.0162585949147 | 0.4 | COL4A1 COL4A2 | Hemiplegia |
| GO:0005788 | 0.0165084833157 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | endoplasmic reticulum lumen |
| HP:0011028 | 0.0169214896417 | 0.6 | PLOD1 COL4A2 COL4A1 | Abnormality of blood circulation |
| HP:0025323 | 0.0201414164419 | 0.4 | PLOD1 COL4A1 | Abnormal arterial physiology |
| HP:0000545 | 0.0273340886952 | 0.6 | PLOD1 COL4A5 COL4A1 | Myopia |
| REAC:R-HSA-9006934 | 0.0291077226575 | 0.6 | COL4A1 COL4A2 COL4A5 | Signaling by Receptor Tyrosine Kinases |
| HP:0011025 | 0.0335159803875 | 0.8 | PLOD1 COL4A1 COL4A2 COL4A5 | Abnormal cardiovascular system physiology |
| GO:0062023 | 0.0413212587053 | 0.8 | COL4A6 COL4A1 COL4A2 COL4A5 | collagen-containing extracellular matrix |
| GO:0044432 | 0.0440230022293 | 1.0 | COL4A6 PLOD1 COL4A1 COL4A2 COL4A5 | endoplasmic reticulum part |
| HP:0001871 | 0.0471879554362 | 0.8 | PLOD1 COL4A1 COL4A2 COL4A5 | Abnormality of blood and blood-forming tissues |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COL4A1 | PLOD1 | 0.854 | 0.793 | hein_WMM bioplex (PLOD1) bioplex_WMM |
| COL4A2 | PLOD1 | 0.602 | 0.671 | bioplex (PLOD1) bioplex_WMM boldt_WMM |
| PLOD1 | COL4A6 | 0.524 | 0.635 | bioplex (PLOD1) bioplex_WMM |
| PLOD1 | COL4A5 | 0.5 | 0.621 | bioplex (PLOD1) bioplex_WMM |
| COL4A1 | COL4A2 | 0.012 | 0.149 | bioplex_WMM WMM_only |
| COL4A1 | COL4A5 | 0.011 | 0.148 | bioplex_WMM WMM_only |
| COL4A2 | COL4A6 | 0.011 | 0.142 | bioplex_WMM WMM_only |
| COL4A1 | COL4A6 | 0.011 | 0.145 | bioplex_WMM WMM_only |
| COL4A2 | COL4A5 | 0.01 | 0.122 | bioplex_WMM WMM_only |
| COL4A6 | COL4A5 | 0.009 | 0.107 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04238 has an average edge precision of 0.353 which is ranked 3881 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PLOD1 | HuMAP2_02722 HuMAP2_02856 HuMAP2_04238 HuMAP2_04483 HuMAP2_05080 |
| COL4A2 | HuMAP2_02722 HuMAP2_04238 HuMAP2_05080 HuMAP2_06216 HuMAP2_06790 |
| COL4A5 | HuMAP2_04238 HuMAP2_05080 HuMAP2_05161 HuMAP2_05432 |
| COL4A6 | HuMAP2_02856 HuMAP2_04238 HuMAP2_05080 |
| COL4A1 | HuMAP2_01361 HuMAP2_02856 HuMAP2_04238 HuMAP2_04483 HuMAP2_05080 HuMAP2_05564 |