hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04246
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) | UniProt NCBI |
| LYPLA1 | Acyl-protein thioesterase 1 (APT-1) (hAPT1) (EC 3.1.2.-) (Lysophospholipase 1) (Lysophospholipase I) (LPL-I) (LysoPLA I) | UniProt NCBI |
| LGALS3 | Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) | UniProt NCBI |
| MDH1 | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Cytosolic malate dehydrogenase) (Diiodophenylpyruvate reductase) (EC 1.1.1.96) | UniProt NCBI |
| PPIA | Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed] | UniProt NCBI |
| DBI | Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP) | UniProt NCBI |
| PGM1 | Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) | UniProt NCBI |
| FABP5 | Fatty acid-binding protein 5 (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein, epidermal) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP) | UniProt NCBI |
| MSRA | Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR) | UniProt NCBI |
| ME3 | NADP-dependent malic enzyme, mitochondrial (NADP-ME) (EC 1.1.1.40) (Malic enzyme 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03320 | 0.000584726257012 | 0.3 | ME3 DBI FABP5 | PPAR signaling pathway |
| WP:WP4595 | 0.0052826264231 | 0.2 | ALDH4A1 MDH1 | Urea cycle and associated pathways |
| REAC:R-HSA-1430728 | 0.00885685584845 | 0.7 | MDH1 LYPLA1 DBI ALDH4A1 FABP5 ME3 PGM1 | Metabolism |
| KEGG:00620 | 0.0142642002018 | 0.2 | MDH1 ME3 | Pyruvate metabolism |
| REAC:R-HSA-6798695 | 0.0264504553476 | 0.4 | LGALS3 PPIA PGM1 FABP5 | Neutrophil degranulation |
| WP:WP3942 | 0.0483946984354 | 0.2 | DBI FABP5 | PPAR signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ALDH4A1 | FABP5 | 0.996 | 0.926 | Guru fraction |
| PPIA | ALDH4A1 | 0.944 | 0.856 | fraction |
| MSRA | ALDH4A1 | 0.863 | 0.8 | fraction |
| PGM1 | ALDH4A1 | 0.762 | 0.749 | fraction treiber_WMM |
| DBI | ALDH4A1 | 0.76 | 0.75 | fraction |
| MSRA | DBI | 0.701 | 0.723 | fraction |
| MSRA | FABP5 | 0.604 | 0.671 | fraction |
| DBI | FABP5 | 0.593 | 0.665 | bioplex_WMM Guru fraction treiber_WMM |
| MDH1 | FABP5 | 0.5 | 0.621 | bioplex_WMM fraction boldt_WMM treiber_WMM |
| LGALS3 | ALDH4A1 | 0.455 | 0.595 | bioplex_WMM fraction |
| PPIA | MDH1 | 0.336 | 0.527 | bioplex (MDH1) bioplex_WMM fraction boldt_WMM treiber_WMM |
| PGM1 | MDH1 | 0.319 | 0.511 | bioplex (MDH1) bioplex_WMM fraction treiber_WMM |
| PGM1 | ME3 | 0.276 | 0.487 | fraction |
| DBI | LGALS3 | 0.261 | 0.482 | bioplex_WMM fraction treiber_WMM |
| MSRA | LGALS3 | 0.22 | 0.466 | fraction |
| MSRA | ME3 | 0.213 | 0.462 | fraction |
| ALDH4A1 | MDH1 | 0.159 | 0.417 | fraction treiber_WMM |
| MSRA | LYPLA1 | 0.145 | 0.408 | fraction |
| LGALS3 | FABP5 | 0.131 | 0.402 | bioplex_WMM fraction boldt_WMM treiber_WMM |
| LGALS3 | MDH1 | 0.126 | 0.399 | bioplex (LGALS3) bioplex_WMM fraction treiber_WMM |
| ALDH4A1 | ME3 | 0.093 | 0.355 | fraction |
| PGM1 | FABP5 | 0.083 | 0.349 | bioplex_WMM fraction |
| DBI | MDH1 | 0.081 | 0.349 | bioplex_WMM fraction |
| MSRA | MDH1 | 0.079 | 0.351 | fraction |
| PPIA | FABP5 | 0.079 | 0.353 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| ME3 | LYPLA1 | 0.063 | 0.348 | fraction |
| ALDH4A1 | LYPLA1 | 0.051 | 0.295 | fraction |
| MSRA | PPIA | 0.05 | 0.296 | fraction |
| PPIA | PGM1 | 0.042 | 0.269 | bioplex_WMM fraction |
| MSRA | PGM1 | 0.039 | 0.264 | fraction |
| LGALS3 | LYPLA1 | 0.032 | 0.245 | bioplex_WMM fraction |
| ME3 | MDH1 | 0.015 | 0.148 | fraction |
| PPIA | LYPLA1 | 0.011 | 0.145 | fraction treiber_WMM |
| PGM1 | LYPLA1 | 0.01 | 0.121 | bioplex_WMM fraction |
| LGALS3 | PPIA | 0.008 | 0.03 | bioplex (LGALS3) bioplex_WMM fraction treiber_WMM |
| LGALS3 | PGM1 | 0.0 | 0.01 | bioplex (LGALS3) bioplex_WMM fraction |
| FABP5 | LYPLA1 | 0.0 | 0.01 | fraction treiber_WMM |
| DBI | PGM1 | 0.0 | 0.008 | bioplex_WMM fraction |
| DBI | PPIA | 0.0 | 0.001 | bioplex_WMM fraction treiber_WMM |
| DBI | LYPLA1 | 0.0 | 0.001 | bioplex_WMM fraction |
| MDH1 | LYPLA1 | 0.0 | 0.001 | bioplex_WMM fraction |
Images
Click to enlarge
Complex HuMAP2_04246 has an average edge precision of 0.387 which is ranked 3460 out of all 6965 complexes.
Related Complexes