hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04253

Confidence: Medium High

Genename	Protein Name	Links
SNX27	Sorting nexin-27	UniProt NCBI
TTR	Transthyretin (ATTR) (Prealbumin) (TBPA)	UniProt NCBI
CDS1	Phosphatidate cytidylyltransferase 1 (EC 2.7.7.41) (CDP-DAG synthase 1) (CDP-DG synthase 1) (CDP-diacylglycerol synthase 1) (CDS 1) (CDP-diglyceride pyrophosphorylase 1) (CDP-diglyceride synthase 1) (CTP:phosphatidate cytidylyltransferase 1)	UniProt NCBI
APOA1	Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))]	UniProt NCBI
APOA2	Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))]	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-975634	2.88749669481e-05	0.6	APOA1 TTR APOA2	Retinoid metabolism and transport
REAC:R-HSA-6806667	3.58634423945e-05	0.6	APOA1 TTR APOA2	Metabolism of fat-soluble vitamins
WP:WP3601	7.00810045876e-05	0.4	APOA1 APOA2	Composition of Lipid Particles
REAC:R-HSA-2187338	0.00018227939524	0.6	APOA1 TTR APOA2	Visual phototransduction
REAC:R-HSA-8963901	0.000283261545489	0.4	APOA1 APOA2	Chylomicron remodeling
WP:WP4522	0.0003033988973	0.4	APOA1 APOA2	Metabolic pathway of LDL, HDL and TG, including diseases
REAC:R-HSA-8963888	0.000485460775426	0.4	APOA1 APOA2	Chylomicron assembly
WP:WP430	0.000842496056343	0.4	APOA1 APOA2	Statin Pathway
WP:WP2878	0.000918963086269	0.4	APOA1 APOA2	PPAR Alpha Pathway
REAC:R-HSA-8963898	0.00141478632427	0.4	APOA1 APOA2	Plasma lipoprotein assembly
REAC:R-HSA-196854	0.00215073577643	0.6	APOA1 TTR APOA2	Metabolism of vitamins and cofactors
REAC:R-HSA-8963899	0.0031096034254	0.4	APOA1 APOA2	Plasma lipoprotein remodeling
KEGG:04979	0.00385577589725	0.4	APOA1 APOA2	Cholesterol metabolism
WP:WP3942	0.00646864373199	0.4	APOA1 APOA2	PPAR signaling pathway
REAC:R-HSA-418594	0.00775951386318	0.6	APOA1 TTR APOA2	G alpha (i) signalling events
HP:0000991	0.00973521215689	0.4	APOA1 APOA2	Xanthomatosis
HP:0011034	0.00973521215689	0.4	APOA1 TTR	Amyloidosis
KEGG:03320	0.0105709544625	0.4	APOA1 APOA2	PPAR signaling pathway
GO:0010903	0.0135228859698	0.4	APOA1 APOA2	negative regulation of very-low-density lipoprotein particle remodeling
GO:0002740	0.0135228859698	0.4	APOA1 APOA2	negative regulation of cytokine secretion involved in immune response
GO:0070653	0.0135228859698	0.4	APOA1 APOA2	high-density lipoprotein particle receptor binding
GO:0060228	0.0135228859698	0.4	APOA1 APOA2	phosphatidylcholine-sterol O-acyltransferase activator activity
REAC:R-HSA-174824	0.0206361227401	0.4	APOA1 APOA2	Plasma lipoprotein assembly, remodeling, and clearance
GO:0010901	0.0270421395626	0.4	APOA1 APOA2	regulation of very-low-density lipoprotein particle remodeling
CORUM:13	0.0499494897235	0.2	CDS1	MUS81-CDS1 complex
CORUM:6821	0.0499494897235	0.2	TTR	TTR-RBP complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
CDS1	SNX27	0.09	0.355	bioplex (CDS1) bioplex_WMM
TTR	SNX27	0.071	0.353	bioplex (SNX27) bioplex_WMM
APOA1	SNX27	0.049	0.293	bioplex (SNX27) bioplex_WMM
SNX27	APOA2	0.04	0.267	bioplex (SNX27) bioplex_WMM
APOA1	APOA2	0.009	0.111	bioplex_WMM WMM_only
TTR	APOA1	0.008	0.085	bioplex_WMM WMM_only treiber_WMM
TTR	APOA2	0.008	0.06	bioplex_WMM WMM_only

Images

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Complex HuMAP2_04253 has an average edge precision of 0.218 which is ranked 5896 out of all 6965 complexes.

Related Complexes

Genename	Complexes
SNX27	HuMAP2_04253
TTR	HuMAP2_01959 HuMAP2_04253
CDS1	HuMAP2_01450 HuMAP2_04253 HuMAP2_04601
APOA1	HuMAP2_04253 HuMAP2_04466 HuMAP2_06606
APOA2	HuMAP2_04253 HuMAP2_04634

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04253