hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04257
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| OPTN | Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP) | UniProt NCBI |
| TBKBP1 | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | UniProt NCBI |
| TBK1 | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5212 | 9.39429153233e-05 | 0.666666666667 | TBK1 TBKBP1 | Kinase maturation complex 2 |
| KEGG:04137 | 0.000844586654193 | 0.666666666667 | TBK1 OPTN | Mitophagy - animal |
| KEGG:04622 | 0.000900335185999 | 0.666666666667 | TBK1 TBKBP1 | RIG-I-like receptor signaling pathway |
| WP:WP3865 | 0.00136941813981 | 0.666666666667 | TBK1 TBKBP1 | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| HP:0030195 | 0.00525183643236 | 0.666666666667 | TBK1 OPTN | Fatigable weakness of swallowing muscles |
| HP:0025425 | 0.00556051868131 | 0.666666666667 | TBK1 OPTN | Laryngospasm |
| HP:0025424 | 0.0079675754074 | 0.666666666667 | TBK1 OPTN | Abnormal larynx physiology |
| HP:0007354 | 0.0079675754074 | 0.666666666667 | TBK1 OPTN | Amyotrophic lateral sclerosis |
| HP:0000217 | 0.00995061979035 | 0.666666666667 | TBK1 OPTN | Xerostomia |
| HP:0030192 | 0.0103735850487 | 0.666666666667 | TBK1 OPTN | Fatigable weakness of bulbar muscles |
| HP:0030196 | 0.0112458624499 | 0.666666666667 | TBK1 OPTN | Fatigable weakness of respiratory muscles |
| HP:0007373 | 0.0121532611158 | 0.666666666667 | TBK1 OPTN | Motor neuron atrophy |
| HP:0002450 | 0.0183346678183 | 0.666666666667 | TBK1 OPTN | Abnormal motor neuron morphology |
| HP:0002180 | 0.0194876494112 | 0.666666666667 | TBK1 OPTN | Neurodegeneration |
| HP:0002380 | 0.0194876494112 | 0.666666666667 | TBK1 OPTN | Fasciculations |
| HP:0012757 | 0.0194876494112 | 0.666666666667 | TBK1 OPTN | Abnormal neuron morphology |
| HP:0000713 | 0.028539256711 | 0.666666666667 | TBK1 OPTN | Agitation |
| HP:0003473 | 0.0376620740847 | 0.666666666667 | TBK1 OPTN | Fatigable weakness |
| HP:0030191 | 0.0384790851177 | 0.666666666667 | TBK1 OPTN | Abnormal peripheral nervous system synaptic transmission |
| HP:0000711 | 0.0384790851177 | 0.666666666667 | TBK1 OPTN | Restlessness |
| HP:0012535 | 0.0384790851177 | 0.666666666667 | TBK1 OPTN | Abnormal synaptic transmission |
| HP:0003398 | 0.0384790851177 | 0.666666666667 | TBK1 OPTN | Abnormal synaptic transmission at the neuromuscular junction |
| HP:0003324 | 0.044442515366 | 0.666666666667 | TBK1 OPTN | Generalized muscle weakness |
| HP:0000712 | 0.0462248590062 | 0.666666666667 | TBK1 OPTN | Emotional lability |
| HP:0003470 | 0.0489637608732 | 0.666666666667 | TBK1 OPTN | Paralysis |
| CORUM:7405 | 0.0499776345577 | 0.333333333333 | TBK1 | TMEM173-TBK1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TBK1 | TBKBP1 | 0.073 | 0.356 | youn (TBK1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| TBK1 | OPTN | 0.059 | 0.328 | youn (TBK1) bioplex_WMM youn_WMM gupta_WMM |
| TBKBP1 | OPTN | 0.007 | 0.002 | youn_WMM WMM_only |
Images
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Complex HuMAP2_04257 has an average edge precision of 0.229 which is ranked 5723 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| OPTN | HuMAP2_04257 HuMAP2_04412 |
| TBKBP1 | HuMAP2_04257 HuMAP2_06259 |
| TBK1 | HuMAP2_04257 HuMAP2_06259 HuMAP2_06452 HuMAP2_06729 |