hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04270
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PSMB5 | Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X) | UniProt NCBI |
| PSMB4 | Proteasome subunit beta type-4 (EC 3.4.25.1) (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3) | UniProt NCBI |
| PSMB3 | Proteasome subunit beta type-3 (EC 3.4.25.1) (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain) | UniProt NCBI |
| PSME2 | Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:192 | 8.25277354287e-11 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | PA28-20S proteasome |
| CORUM:193 | 2.67104189859e-09 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | PA700-20S-PA28 complex |
| KEGG:03050 | 2.69245678788e-09 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Proteasome |
| WP:WP183 | 7.9074196704e-09 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Proteasome Degradation |
| REAC:R-HSA-1236978 | 1.76464250107e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Cross-presentation of soluble exogenous antigens (endosomes) |
| REAC:R-HSA-211733 | 2.08858653508e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
| REAC:R-HSA-350562 | 2.26633858062e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Regulation of ornithine decarboxylase (ODC) |
| REAC:R-HSA-69601 | 2.455200129e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A |
| REAC:R-HSA-75815 | 2.455200129e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Ubiquitin-dependent degradation of Cyclin D |
| REAC:R-HSA-69613 | 2.455200129e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | p53-Independent G1/S DNA damage checkpoint |
| REAC:R-HSA-180534 | 2.455200129e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Vpu mediated degradation of CD4 |
| REAC:R-HSA-349425 | 2.455200129e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Autodegradation of the E3 ubiquitin ligase COP1 |
| REAC:R-HSA-69610 | 2.455200129e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | p53-Independent DNA Damage Response |
| REAC:R-HSA-450408 | 2.65562462933e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | AUF1 (hnRNP D0) binds and destabilizes mRNA |
| REAC:R-HSA-9604323 | 2.65562462933e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Negative regulation of NOTCH4 signaling |
| REAC:R-HSA-169911 | 2.65562462933e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Regulation of Apoptosis |
| REAC:R-HSA-8941858 | 2.65562462933e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Regulation of RUNX3 expression and activity |
| REAC:R-HSA-180585 | 2.65562462933e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Vif-mediated degradation of APOBEC3G |
| REAC:R-HSA-8854050 | 2.86807459968e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis |
| REAC:R-HSA-4641257 | 3.0930216271e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Degradation of AXIN |
| REAC:R-HSA-174113 | 3.0930216271e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | SCF-beta-TrCP mediated degradation of Emi1 |
| REAC:R-HSA-5362768 | 3.0930216271e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Hh mutants that don't undergo autocatalytic processing are degraded by ERAD |
| REAC:R-HSA-69541 | 3.58233854634e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Stabilization of p53 |
| REAC:R-HSA-4641258 | 3.58233854634e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Degradation of DVL |
| REAC:R-HSA-5387390 | 3.58233854634e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Hh mutants abrogate ligand secretion |
| REAC:R-HSA-351202 | 3.58233854634e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Metabolism of polyamines |
| REAC:R-HSA-187577 | 4.12752946315e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | SCF(Skp2)-mediated degradation of p27/p21 |
| REAC:R-HSA-68827 | 4.12752946315e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | CDT1 association with the CDC6:ORC:origin complex |
| REAC:R-HSA-5676590 | 4.12752946315e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | NIK-->noncanonical NF-kB signaling |
| REAC:R-HSA-5610780 | 4.12752946315e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Degradation of GLI1 by the proteasome |
| REAC:R-HSA-5610783 | 4.42235299624e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Degradation of GLI2 by the proteasome |
| REAC:R-HSA-5678895 | 4.42235299624e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Defective CFTR causes cystic fibrosis |
| REAC:R-HSA-5610785 | 4.42235299624e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | GLI3 is processed to GLI3R by the proteasome |
| REAC:R-HSA-5607761 | 4.42235299624e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Dectin-1 mediated noncanonical NF-kB signaling |
| REAC:R-HSA-174084 | 5.05908621651e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Autodegradation of Cdh1 by Cdh1:APC/C |
| REAC:R-HSA-5358346 | 5.05908621651e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Hedgehog ligand biogenesis |
| REAC:R-HSA-4608870 | 5.40207511254e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Asymmetric localization of PCP proteins |
| REAC:R-HSA-1234176 | 6.14006351589e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| REAC:R-HSA-69580 | 6.53619664595e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | p53-Dependent G1/S DNA damage checkpoint |
| REAC:R-HSA-69563 | 6.53619664595e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | p53-Dependent G1 DNA Damage Response |
| REAC:R-HSA-8939902 | 6.53619664595e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Regulation of RUNX2 expression and activity |
| REAC:R-HSA-1169091 | 6.53619664595e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Activation of NF-kappaB in B cells |
| REAC:R-HSA-174154 | 6.53619664595e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | APC/C:Cdc20 mediated degradation of Securin |
| REAC:R-HSA-5658442 | 6.95119325839e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Regulation of RAS by GAPs |
| REAC:R-HSA-8948751 | 7.38564283704e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Regulation of PTEN stability and activity |
| REAC:R-HSA-68867 | 7.38564283704e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Assembly of the pre-replicative complex |
| REAC:R-HSA-69615 | 7.38564283704e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | G1/S DNA Damage Checkpoints |
| REAC:R-HSA-69017 | 8.81174024321e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | CDK-mediated phosphorylation and removal of Cdc6 |
| REAC:R-HSA-68949 | 8.81174024321e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Orc1 removal from chromatin |
| REAC:R-HSA-174184 | 8.81174024321e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| REAC:R-HSA-174178 | 8.81174024321e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| REAC:R-HSA-179419 | 9.33007790458e-08 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| REAC:R-HSA-176409 | 1.04350063852e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-1234174 | 1.04350063852e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Cellular response to hypoxia |
| REAC:R-HSA-176814 | 1.10228940689e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| REAC:R-HSA-5619084 | 1.16352770727e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | ABC transporter disorders |
| REAC:R-HSA-2871837 | 1.16352770727e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | FCERI mediated NF-kB activation |
| REAC:R-HSA-8852276 | 1.16352770727e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-1168372 | 1.22728265013e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Downstream signaling events of B Cell Receptor (BCR) |
| REAC:R-HSA-9013694 | 1.36261543966e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Signaling by NOTCH4 |
| REAC:R-HSA-176408 | 1.36261543966e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Regulation of APC/C activators between G1/S and early anaphase |
| REAC:R-HSA-5632684 | 1.43433204175e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Hedgehog 'on' state |
| REAC:R-HSA-69202 | 1.58621935087e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-195253 | 1.58621935087e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Degradation of beta-catenin by the destruction complex |
| REAC:R-HSA-1236974 | 1.58621935087e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | ER-Phagosome pathway |
| REAC:R-HSA-450531 | 1.74986096744e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| REAC:R-HSA-69656 | 1.74986096744e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Cyclin A:Cdk2-associated events at S phase entry |
| REAC:R-HSA-453276 | 1.83627385472e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Regulation of mitotic cell cycle |
| REAC:R-HSA-5668541 | 1.83627385472e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | TNFR2 non-canonical NF-kB pathway |
| REAC:R-HSA-69002 | 1.83627385472e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | DNA Replication Pre-Initiation |
| REAC:R-HSA-174143 | 1.83627385472e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | APC/C-mediated degradation of cell cycle proteins |
| REAC:R-HSA-5687128 | 2.01866015002e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | MAPK6/MAPK4 signaling |
| REAC:R-HSA-69052 | 2.21430620378e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Switching of origins to a post-replicative state |
| REAC:R-HSA-202424 | 2.21430620378e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Downstream TCR signaling |
| REAC:R-HSA-4086400 | 2.42383958954e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | PCP/CE pathway |
| CORUM:191 | 2.4564793089e-07 | 0.75 | PSMB5 PSMB4 PSMB3 | 20S proteasome |
| REAC:R-HSA-5607764 | 2.53401411634e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-8878159 | 2.53401411634e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Transcriptional regulation by RUNX3 |
| REAC:R-HSA-1236975 | 2.76558694195e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Antigen processing-Cross presentation |
| CORUM:194 | 3.07044439662e-07 | 0.75 | PSMB5 PSMB4 PSMB3 | PA28gamma-20S proteasome |
| REAC:R-HSA-9020702 | 3.14225712992e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Interleukin-1 signaling |
| REAC:R-HSA-382556 | 3.41390578662e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | ABC-family proteins mediated transport |
| REAC:R-HSA-5689603 | 3.55615186106e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | UCH proteinases |
| REAC:R-HSA-983705 | 3.70279729863e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Signaling by the B Cell Receptor (BCR) |
| REAC:R-HSA-8878166 | 4.1700321538e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Transcriptional regulation by RUNX2 |
| REAC:R-HSA-202403 | 4.68014787616e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | TCR signaling |
| REAC:R-HSA-5610787 | 5.43141780353e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Hedgehog 'off' state |
| REAC:R-HSA-69239 | 6.95938708355e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Synthesis of DNA |
| REAC:R-HSA-2454202 | 7.44977867715e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-162909 | 7.96564050645e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Host Interactions of HIV factors |
| REAC:R-HSA-69306 | 9.07725736124e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | DNA Replication |
| REAC:R-HSA-8939236 | 9.07725736124e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
| REAC:R-HSA-446652 | 9.07725736124e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Interleukin-1 family signaling |
| REAC:R-HSA-5621481 | 9.07725736124e-07 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | C-type lectin receptors (CLRs) |
| REAC:R-HSA-69206 | 1.03013477297e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | G1/S Transition |
| CORUM:181 | 1.03886072065e-06 | 0.75 | PSMB5 PSMB4 PSMB3 | 26S proteasome |
| REAC:R-HSA-6807070 | 1.20008341302e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | PTEN Regulation |
| REAC:R-HSA-3858494 | 1.2736360305e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Beta-catenin independent WNT signaling |
| REAC:R-HSA-5358351 | 1.47230432248e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Signaling by Hedgehog |
| REAC:R-HSA-453279 | 1.69335486182e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Mitotic G1-G1/S phases |
| REAC:R-HSA-5619115 | 2.15285977026e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Disorders of transmembrane transporters |
| REAC:R-HSA-69242 | 2.3250149843e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | S Phase |
| REAC:R-HSA-69481 | 2.83465132028e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | G2/M Checkpoints |
| REAC:R-HSA-9010553 | 2.90378915736e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Regulation of expression of SLITs and ROBOs |
| REAC:R-HSA-109581 | 2.97418404602e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Apoptosis |
| REAC:R-HSA-5357801 | 3.19306292696e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Programmed Cell Death |
| REAC:R-HSA-2467813 | 4.10034927091e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Separation of Sister Chromatids |
| REAC:R-HSA-69275 | 4.77048083087e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | G2/M Transition |
| REAC:R-HSA-68882 | 4.87252320159e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 4.976193908e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-453274 | 4.976193908e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Mitotic G2-G2/M phases |
| REAC:R-HSA-5689880 | 4.976193908e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Ub-specific processing proteases |
| REAC:R-HSA-5673001 | 5.1884893429e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 5.74894108903e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9607240 | 7.27878120934e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | FLT3 Signaling |
| REAC:R-HSA-376176 | 7.56074356572e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Signaling by ROBO receptors |
| GO:0000502 | 7.71512067313e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | proteasome complex |
| GO:1905369 | 8.3202281769e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | endopeptidase complex |
| REAC:R-HSA-8878171 | 8.45593016469e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-157118 | 8.61252146403e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Signaling by NOTCH |
| REAC:R-HSA-8951664 | 8.93221849381e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Neddylation |
| REAC:R-HSA-201681 | 8.93221849381e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | TCF dependent signaling in response to WNT |
| GO:0006521 | 8.96024572897e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of cellular amino acid metabolic process |
| REAC:R-HSA-162906 | 9.09536403708e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | HIV Infection |
| REAC:R-HSA-1257604 | 9.42834939261e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | PIP3 activates AKT signaling |
| REAC:R-HSA-449836 | 9.77039511453e-06 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Other interleukin signaling |
| REAC:R-HSA-5683057 | 1.14261241307e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | MAPK family signaling cascades |
| GO:0033238 | 1.18961295599e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of cellular amine metabolic process |
| REAC:R-HSA-9006925 | 1.76692529985e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Intracellular signaling by second messengers |
| REAC:R-HSA-5688426 | 1.84941544435e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Deubiquitination |
| GO:1902036 | 1.98673792316e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of hematopoietic stem cell differentiation |
| GO:0002479 | 2.50979095633e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| REAC:R-HSA-69620 | 2.51048958535e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Cell Cycle Checkpoints |
| GO:1905368 | 2.65528608423e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | peptidase complex |
| REAC:R-HSA-983168 | 2.69103270077e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Antigen processing: Ubiquitination & Proteasome degradation |
| GO:0060218 | 2.80701671762e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | hematopoietic stem cell differentiation |
| GO:0042590 | 2.96515850453e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | antigen processing and presentation of exogenous peptide antigen via MHC class I |
| GO:0061418 | 2.96515850453e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| REAC:R-HSA-195721 | 3.42260325769e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Signaling by WNT |
| GO:1901532 | 3.47984386015e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of hematopoietic progenitor cell differentiation |
| GO:0031145 | 3.85835319231e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | anaphase-promoting complex-dependent catabolic process |
| GO:0010972 | 4.48297714516e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | negative regulation of G2/M transition of mitotic cell cycle |
| REAC:R-HSA-5663202 | 4.78748852749e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Diseases of signal transduction |
| GO:0031146 | 5.43019580356e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| REAC:R-HSA-71291 | 5.51007535999e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Metabolism of amino acids and derivatives |
| REAC:R-HSA-983169 | 5.51007535999e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Class I MHC mediated antigen processing & presentation |
| GO:0019774 | 5.99161085695e-05 | 0.75 | PSMB5 PSMB4 PSMB3 | proteasome core complex, beta-subunit complex |
| REAC:R-HSA-5663205 | 6.10347103542e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Infectious disease |
| GO:0060071 | 6.2335294411e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Wnt signaling pathway, planar cell polarity pathway |
| GO:0002474 | 6.52012849586e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | antigen processing and presentation of peptide antigen via MHC class I |
| GO:0090175 | 6.52012849586e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of establishment of planar polarity |
| GO:2000736 | 7.43942887385e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of stem cell differentiation |
| REAC:R-HSA-68886 | 7.5124113335e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | M Phase |
| GO:1902750 | 7.76643673643e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | negative regulation of cell cycle G2/M phase transition |
| GO:0070498 | 7.76643673643e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | interleukin-1-mediated signaling pathway |
| GO:0007164 | 8.10410789889e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | establishment of tissue polarity |
| GO:0001736 | 8.10410789889e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | establishment of planar polarity |
| GO:0002244 | 8.45267167948e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | hematopoietic progenitor cell differentiation |
| GO:0044106 | 8.81235983606e-05 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | cellular amine metabolic process |
| REAC:R-HSA-2262752 | 0.00010216546718 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Cellular responses to stress |
| GO:0038095 | 0.000103670767632 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Fc-epsilon receptor signaling pathway |
| GO:0002223 | 0.000103670767632 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | stimulatory C-type lectin receptor signaling pathway |
| GO:0002220 | 0.000107859485517 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | innate immune response activating cell surface receptor signaling pathway |
| GO:0009308 | 0.000116616394242 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | amine metabolic process |
| GO:0043618 | 0.000121189586173 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of transcription from RNA polymerase II promoter in response to stress |
| GO:0001738 | 0.000135718631087 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | morphogenesis of a polarized epithelium |
| GO:0043620 | 0.000146105138915 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of DNA-templated transcription in response to stress |
| GO:0090263 | 0.000174678196193 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | positive regulation of canonical Wnt signaling pathway |
| REAC:R-HSA-8953897 | 0.00021167720149 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Cellular responses to external stimuli |
| GO:1905330 | 0.000228860884329 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of morphogenesis of an epithelium |
| GO:0038061 | 0.000236426533398 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | NIK/NF-kappaB signaling |
| REAC:R-HSA-449147 | 0.000252642799005 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Signaling by Interleukins |
| REAC:R-HSA-422475 | 0.000258657869731 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Axon guidance |
| REAC:R-HSA-69278 | 0.000264779714116 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Cell Cycle, Mitotic |
| GO:0071347 | 0.000285834009959 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | cellular response to interleukin-1 |
| GO:0033209 | 0.000285834009959 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | tumor necrosis factor-mediated signaling pathway |
| GO:0035567 | 0.000285834009959 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | non-canonical Wnt signaling pathway |
| GO:0010565 | 0.00029476632277 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of cellular ketone metabolic process |
| GO:0071456 | 0.000342608092204 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | cellular response to hypoxia |
| GO:0036294 | 0.000373974563235 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | cellular response to decreased oxygen levels |
| GO:0030177 | 0.000384893528585 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | positive regulation of Wnt signaling pathway |
| GO:0090090 | 0.000396049862747 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | negative regulation of canonical Wnt signaling pathway |
| GO:0005839 | 0.000413778117181 | 0.75 | PSMB5 PSMB4 PSMB3 | proteasome core complex |
| GO:0070555 | 0.000419088323416 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | response to interleukin-1 |
| GO:2000027 | 0.000443117561019 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of animal organ morphogenesis |
| REAC:R-HSA-382551 | 0.000491356075286 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Transport of small molecules |
| GO:0071453 | 0.000521431948115 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | cellular response to oxygen levels |
| GO:0050852 | 0.000521431948115 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | T cell receptor signaling pathway |
| REAC:R-HSA-1640170 | 0.000545854331888 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Cell Cycle |
| GO:0010499 | 0.000558907067709 | 0.75 | PSMB5 PSMB4 PSMB3 | proteasomal ubiquitin-independent protein catabolic process |
| GO:0043488 | 0.000625429030777 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of mRNA stability |
| GO:0030178 | 0.000657808747052 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | negative regulation of Wnt signaling pathway |
| REAC:R-HSA-1280218 | 0.000660113802024 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Adaptive Immune System |
| GO:0038093 | 0.000674462133054 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Fc receptor signaling pathway |
| REAC:R-HSA-8953854 | 0.000676603019954 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Metabolism of RNA |
| GO:0002478 | 0.000691429733885 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | antigen processing and presentation of exogenous peptide antigen |
| GO:0043487 | 0.000691429733885 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of RNA stability |
| GO:0048863 | 0.000726323315176 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | stem cell differentiation |
| GO:0019884 | 0.000726323315176 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | antigen processing and presentation of exogenous antigen |
| REAC:R-HSA-1280215 | 0.000849103795306 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Cytokine Signaling in Immune system |
| GO:0048002 | 0.000879263724448 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | antigen processing and presentation of peptide antigen |
| GO:0010389 | 0.000942422491033 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of G2/M transition of mitotic cell cycle |
| GO:0042180 | 0.000942422491033 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | cellular ketone metabolic process |
| GO:0061013 | 0.000986378413477 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of mRNA catabolic process |
| GO:0071356 | 0.00103185430137 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | cellular response to tumor necrosis factor |
| GO:0050851 | 0.00117775012637 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | antigen receptor-mediated signaling pathway |
| GO:0001666 | 0.00120349329853 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | response to hypoxia |
| GO:0036293 | 0.0012832593435 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | response to decreased oxygen levels |
| GO:1902749 | 0.00133859616125 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of cell cycle G2/M phase transition |
| GO:0019882 | 0.0014249330287 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | antigen processing and presentation |
| GO:0034612 | 0.0014249330287 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | response to tumor necrosis factor |
| GO:1901991 | 0.00151538042626 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | negative regulation of mitotic cell cycle phase transition |
| GO:0070482 | 0.00164259339851 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | response to oxygen levels |
| GO:1901988 | 0.00195799214531 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | negative regulation of cell cycle phase transition |
| GO:0060828 | 0.00215171705405 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of canonical Wnt signaling pathway |
| REAC:R-HSA-168249 | 0.00243001134371 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Innate Immune System |
| GO:0000086 | 0.00249113752463 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | G2/M transition of mitotic cell cycle |
| REAC:R-HSA-1266738 | 0.00270117638515 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Developmental Biology |
| REAC:R-HSA-1643685 | 0.00304553054305 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Disease |
| GO:0002758 | 0.00340048705072 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | innate immune response-activating signal transduction |
| GO:0044839 | 0.00340048705072 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | cell cycle G2/M phase transition |
| GO:0016579 | 0.00357336290284 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | protein deubiquitination |
| GO:0060070 | 0.0038760338754 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | canonical Wnt signaling pathway |
| REAC:R-HSA-212436 | 0.00429443977897 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Generic Transcription Pathway |
| GO:0002218 | 0.00460927796737 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | activation of innate immune response |
| GO:0070646 | 0.00460927796737 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | protein modification by small protein removal |
| GO:0045930 | 0.00512711596139 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | negative regulation of mitotic cell cycle |
| GO:0000209 | 0.0053619122614 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | protein polyubiquitination |
| GO:0030111 | 0.00544194080262 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of Wnt signaling pathway |
| GO:0002009 | 0.00568740796512 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | morphogenesis of an epithelium |
| GO:0002429 | 0.00629241325149 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | immune response-activating cell surface receptor signaling pathway |
| REAC:R-HSA-73857 | 0.00664358115488 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | RNA Polymerase II Transcription |
| GO:0010948 | 0.00665909549353 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | negative regulation of cell cycle process |
| GO:1903311 | 0.00665909549353 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of mRNA metabolic process |
| GO:0006520 | 0.0074402986 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | cellular amino acid metabolic process |
| GO:1903706 | 0.00785572034373 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of hemopoiesis |
| GO:0045089 | 0.00785572034373 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | positive regulation of innate immune response |
| GO:0062012 | 0.00817852106979 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of small molecule metabolic process |
| GO:0002768 | 0.008399180142 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | immune response-regulating cell surface receptor signaling pathway |
| GO:0002833 | 0.00908800530817 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | positive regulation of response to biotic stimulus |
| REAC:R-HSA-597592 | 0.0094488419023 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Post-translational protein modification |
| REAC:R-HSA-74160 | 0.0102868657133 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Gene expression (Transcription) |
| GO:0043687 | 0.011836710023 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | post-translational protein modification |
| GO:0006402 | 0.0128783441389 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | mRNA catabolic process |
| GO:1901990 | 0.0146522218849 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of mitotic cell cycle phase transition |
| GO:0045088 | 0.0151662917405 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of innate immune response |
| GO:0048729 | 0.015340616933 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | tissue morphogenesis |
| GO:0031349 | 0.0158726177701 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | positive regulation of defense response |
| GO:0043161 | 0.0173589907761 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| GO:0016055 | 0.0175518684514 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Wnt signaling pathway |
| GO:0006401 | 0.0181401540934 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | RNA catabolic process |
| GO:0198738 | 0.0183394964461 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | cell-cell signaling by wnt |
| GO:1901987 | 0.0193609640933 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of cell cycle phase transition |
| GO:0002831 | 0.0226824675867 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | regulation of response to biotic stimulus |
| GO:1905114 | 0.0243708967076 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | cell surface receptor signaling pathway involved in cell-cell signaling |
| GO:0002757 | 0.0285830601899 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | immune response-activating signal transduction |
| GO:0010498 | 0.0294299148014 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | proteasomal protein catabolic process |
| GO:0043902 | 0.031479024466 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | positive regulation of multi-organism process |
| GO:0032103 | 0.0336333206188 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | positive regulation of response to external stimulus |
| GO:0002764 | 0.0352384618295 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | immune response-regulating signaling pathway |
| REAC:R-HSA-168256 | 0.0358063812597 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Immune System |
| REAC:R-HSA-392499 | 0.0403329683602 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Metabolism of proteins |
| GO:0034655 | 0.0445306239544 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | nucleobase-containing compound catabolic process |
| REAC:R-HSA-1430728 | 0.0467536218007 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | Metabolism |
| GO:0044772 | 0.0485535587519 | 1.0 | PSMB5 PSME2 PSMB4 PSMB3 | mitotic cell cycle phase transition |
| CORUM:30 | 0.0499140284799 | 0.25 | PSME2 | PA28 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PSMB4 | PSMB5 | 1.0 | 0.949 | hein_WMM bioplex (PSMB4) bioplex_WMM Guru boldt youn_WMM hein (PSMB4,PSMB5) Malo fraction boldt_WMM treiber_WMM |
| PSMB3 | PSMB4 | 1.0 | 0.949 | hein_WMM bioplex (PSMB3,PSMB4) bioplex_WMM boldt youn_WMM hein (PSMB4) boldt_WMM treiber_WMM |
| PSMB3 | PSMB5 | 0.995 | 0.923 | hein_WMM bioplex (PSMB3) bioplex_WMM boldt youn_WMM hein (PSMB5) boldt_WMM treiber_WMM |
| PSME2 | PSMB4 | 0.961 | 0.868 | hein_WMM bioplex (PSMB4) bioplex_WMM youn_WMM hein (PSMB4) treiber_WMM |
| PSMB3 | PSME2 | 0.807 | 0.767 | hein_WMM bioplex (PSMB3) bioplex_WMM treiber_WMM |
| PSME2 | PSMB5 | 0.774 | 0.752 | hein_WMM bioplex_WMM youn_WMM hein (PSMB5) treiber_WMM |
Images
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Complex HuMAP2_04270 has an average edge precision of 0.868 which is ranked 696 out of all 6965 complexes.
Related Complexes