hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04276
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | UniProt NCBI |
| AIP | AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (HBV X-associated protein 2) (XAP-2) (Immunophilin homolog ARA9) | UniProt NCBI |
| GSTT2B | Glutathione S-transferase theta-2B (EC 2.5.1.18) (GST class-theta-2) (Glutathione S-transferase theta-2) | UniProt NCBI |
| RRM2 | Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) | UniProt NCBI |
| NMD3 | 60S ribosomal export protein NMD3 (hNMD3) | UniProt NCBI |
| RAD23A | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00480 | 3.07711048716e-05 | 0.5 | RRM2B RRM2 GSTT2B | Glutathione metabolism |
| KEGG:00983 | 9.92621413242e-05 | 0.5 | RRM2B RRM2 GSTT2B | Drug metabolism - other enzymes |
| WP:WP4584 | 0.000585450803921 | 0.333333333333 | RRM2B RRM2 | Biomarkers for pyrimidine metabolism disorders |
| WP:WP4225 | 0.000758026533465 | 0.333333333333 | RRM2B RRM2 | Pyrimidine metabolism and related diseases |
| WP:WP404 | 0.000952765433858 | 0.333333333333 | RRM2B RRM2 | Nucleotide Metabolism |
| KEGG:00240 | 0.0076045655811 | 0.333333333333 | RRM2B RRM2 | Pyrimidine metabolism |
| REAC:R-HSA-499943 | 0.00774747127227 | 0.333333333333 | RRM2B RRM2 | Interconversion of nucleotide di- and triphosphates |
| KEGG:04115 | 0.0124835568261 | 0.333333333333 | RRM2B RRM2 | p53 signaling pathway |
| WP:WP4022 | 0.0169827894955 | 0.333333333333 | RRM2B RRM2 | Pyrimidine metabolism |
| GO:0004748 | 0.020283420769 | 0.333333333333 | RRM2B RRM2 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| GO:0016728 | 0.020283420769 | 0.333333333333 | RRM2B RRM2 | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor |
| GO:0061731 | 0.020283420769 | 0.333333333333 | RRM2B RRM2 | ribonucleoside-diphosphate reductase activity |
| KEGG:00230 | 0.0374860246019 | 0.333333333333 | RRM2B RRM2 | Purine metabolism |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RRM2B | RRM2 | 0.99 | 0.909 | bioplex (RRM2,RRM2B) bioplex_WMM |
| RRM2 | NMD3 | 0.051 | 0.3 | youn_WMM fraction |
| RRM2 | RAD23A | 0.042 | 0.269 | fraction |
| RRM2B | RAD23A | 0.034 | 0.261 | fraction |
| AIP | RAD23A | 0.027 | 0.228 | bioplex_WMM fraction |
| NMD3 | GSTT2B | 0.023 | 0.206 | bioplex (GSTT2B) bioplex_WMM |
| AIP | RRM2 | 0.007 | 0.002 | youn_WMM WMM_only |
| AIP | NMD3 | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_04276 has an average edge precision of 0.272 which is ranked 4992 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RRM2B | HuMAP2_01536 HuMAP2_02802 HuMAP2_03254 HuMAP2_04276 HuMAP2_04714 HuMAP2_05291 |
| AIP | HuMAP2_00023 HuMAP2_01261 HuMAP2_01965 HuMAP2_03836 HuMAP2_04276 |
| GSTT2B | HuMAP2_01791 HuMAP2_04276 HuMAP2_04461 HuMAP2_04901 |
| RRM2 | HuMAP2_01536 HuMAP2_04276 HuMAP2_04714 HuMAP2_05291 |
| NMD3 | HuMAP2_01536 HuMAP2_01791 HuMAP2_04276 HuMAP2_04461 |
| RAD23A | HuMAP2_01536 HuMAP2_04276 HuMAP2_05600 |