hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04278
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDH24 | Cadherin-24 | UniProt NCBI |
| CDH2 | Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) | UniProt NCBI |
| CTNNA3 | Catenin alpha-3 (Alpha T-catenin) (Cadherin-associated protein) | UniProt NCBI |
| CDH12 | Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2) | UniProt NCBI |
| CDH4 | Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-418990 | 6.40139272836e-09 | 0.8 | CDH24 CDH12 CDH2 CDH4 | Adherens junctions interactions |
| REAC:R-HSA-421270 | 4.94701294863e-08 | 0.8 | CDH24 CDH12 CDH2 CDH4 | Cell-cell junction organization |
| WP:WP4540 | 2.00221502161e-07 | 0.8 | CDH24 CDH12 CDH2 CDH4 | Pathways Regulating Hippo Signaling |
| GO:0005913 | 3.4002761148e-07 | 1.0 | CDH24 CDH4 CTNNA3 CDH2 CDH12 | cell-cell adherens junction |
| REAC:R-HSA-446728 | 3.53566687566e-07 | 0.8 | CDH24 CDH12 CDH2 CDH4 | Cell junction organization |
| WP:WP4541 | 3.81944119062e-07 | 0.8 | CDH24 CDH12 CDH2 CDH4 | Hippo-Merlin Signaling Dysregulation |
| GO:0016342 | 8.91404751529e-07 | 0.8 | CDH24 CDH12 CDH2 CDH4 | catenin complex |
| REAC:R-HSA-1500931 | 1.60607455481e-06 | 0.8 | CDH24 CDH12 CDH2 CDH4 | Cell-Cell communication |
| GO:0016339 | 4.983554895e-06 | 0.8 | CDH24 CDH12 CDH2 CDH4 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO:0044331 | 6.37612051417e-06 | 0.8 | CDH24 CDH12 CDH2 CDH4 | cell-cell adhesion mediated by cadherin |
| GO:0007156 | 4.8045251566e-05 | 0.8 | CDH24 CDH12 CDH2 CDH4 | homophilic cell adhesion via plasma membrane adhesion molecules |
| GO:0005911 | 9.79476249228e-05 | 1.0 | CDH24 CDH4 CTNNA3 CDH2 CDH12 | cell-cell junction |
| GO:0045296 | 0.0002150891697 | 1.0 | CDH24 CDH4 CTNNA3 CDH2 CDH12 | cadherin binding |
| GO:0007043 | 0.000324482580121 | 0.8 | CDH24 CDH12 CDH2 CDH4 | cell-cell junction assembly |
| GO:0034332 | 0.000650038064497 | 0.8 | CDH24 CDH12 CDH2 CDH4 | adherens junction organization |
| GO:0045216 | 0.000700189954213 | 0.8 | CDH24 CDH12 CDH2 CDH4 | cell-cell junction organization |
| GO:0050839 | 0.00112578910773 | 1.0 | CDH24 CDH4 CTNNA3 CDH2 CDH12 | cell adhesion molecule binding |
| GO:0019897 | 0.00113692677057 | 0.8 | CDH24 CDH12 CDH2 CDH4 | extrinsic component of plasma membrane |
| GO:0005912 | 0.00131665988921 | 1.0 | CDH24 CDH4 CTNNA3 CDH2 CDH12 | adherens junction |
| GO:0098742 | 0.00141941829177 | 0.8 | CDH24 CDH12 CDH2 CDH4 | cell-cell adhesion via plasma-membrane adhesion molecules |
| GO:0070161 | 0.00148408781077 | 1.0 | CDH24 CDH4 CTNNA3 CDH2 CDH12 | anchoring junction |
| GO:0098609 | 0.00211202416883 | 1.0 | CDH24 CDH4 CTNNA3 CDH2 CDH12 | cell-cell adhesion |
| REAC:R-HSA-525793 | 0.0040368179849 | 0.4 | CDH2 CDH4 | Myogenesis |
| GO:0034329 | 0.00583116822137 | 0.8 | CDH24 CDH12 CDH2 CDH4 | cell junction assembly |
| WP:WP2118 | 0.00776404906893 | 0.4 | CDH2 CTNNA3 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| GO:0030054 | 0.0102956342523 | 1.0 | CDH24 CDH4 CTNNA3 CDH2 CDH12 | cell junction |
| KEGG:05412 | 0.0108715181024 | 0.4 | CDH2 CTNNA3 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| GO:0034330 | 0.0112418496521 | 0.8 | CDH24 CDH12 CDH2 CDH4 | cell junction organization |
| GO:0019898 | 0.0116598248695 | 0.8 | CDH24 CDH12 CDH2 CDH4 | extrinsic component of membrane |
| KEGG:04514 | 0.0213955956609 | 0.4 | CDH2 CDH4 | Cell adhesion molecules (CAMs) |
| GO:0005509 | 0.0284335460005 | 0.8 | CDH24 CDH12 CDH2 CDH4 | calcium ion binding |
| GO:0007155 | 0.0338299131717 | 1.0 | CDH24 CDH4 CTNNA3 CDH2 CDH12 | cell adhesion |
| GO:0022610 | 0.0350140465906 | 1.0 | CDH24 CDH4 CTNNA3 CDH2 CDH12 | biological adhesion |
| CORUM:6269 | 0.0499494897235 | 0.2 | CDH2 | DLL1-CTNNB1-CDH2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CTNNA3 | CDH4 | 0.998 | 0.939 | bioplex (CTNNA3) bioplex_WMM |
| CTNNA3 | CDH12 | 0.722 | 0.732 | bioplex (CTNNA3) bioplex_WMM |
| CTNNA3 | CDH24 | 0.214 | 0.464 | bioplex (CTNNA3) bioplex_WMM |
| CTNNA3 | CDH2 | 0.083 | 0.349 | bioplex (CTNNA3) bioplex_WMM |
| CDH12 | CDH4 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| CDH4 | CDH24 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| CDH12 | CDH24 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| CDH2 | CDH24 | 0.008 | 0.022 | bioplex_WMM WMM_only |
| CDH4 | CDH2 | 0.007 | 0.016 | bioplex_WMM WMM_only |
| CDH12 | CDH2 | 0.007 | 0.016 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04278 has an average edge precision of 0.281 which is ranked 4860 out of all 6965 complexes.
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