hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04281
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSPA1B | Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) | UniProt NCBI |
| METTL21A | Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (HSPA lysine methyltransferase) (HSPA-KMT) (Hepatocellular carcinoma-associated antigen 557b) (Methyltransferase-like protein 21A) | UniProt NCBI |
| CLPB | Caseinolytic peptidase B protein homolog (EC 3.6.1.3) (Suppressor of potassium transport defect 3) | UniProt NCBI |
| PAG1 | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp) | UniProt NCBI |
| ICA1 | Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04213 | 0.00656425237639 | 0.4 | CLPB HSPA1B | Longevity regulating pathway - multiple species |
| MIRNA:hsa-miR-6831-3p | 0.0162837213155 | 0.4 | METTL21A PAG1 | hsa-miR-6831-3p |
| MIRNA:hsa-miR-4703-3p | 0.0282835942562 | 0.4 | CLPB PAG1 | hsa-miR-4703-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ICA1 | CLPB | 0.5 | 0.621 | bioplex (CLPB) bioplex_WMM |
| CLPB | PAG1 | 0.06 | 0.333 | bioplex (CLPB) bioplex_WMM |
| HSPA1B | CLPB | 0.05 | 0.297 | bioplex (CLPB) bioplex_WMM boldt |
| METTL21A | HSPA1B | 0.046 | 0.292 | bioplex (METTL21A) bioplex_WMM boldt |
| ICA1 | PAG1 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| HSPA1B | PAG1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04281 has an average edge precision of 0.258 which is ranked 5251 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HSPA1B | HuMAP2_00689 HuMAP2_01327 HuMAP2_01418 HuMAP2_04281 |
| METTL21A | HuMAP2_00689 HuMAP2_01418 HuMAP2_04281 HuMAP2_05624 |
| CLPB | HuMAP2_01046 HuMAP2_04281 HuMAP2_04564 HuMAP2_05256 HuMAP2_06873 |
| PAG1 | HuMAP2_04281 HuMAP2_05256 HuMAP2_06873 |
| ICA1 | HuMAP2_00559 HuMAP2_04281 HuMAP2_04564 HuMAP2_05256 HuMAP2_06534 HuMAP2_06873 |