hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04287
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDKN1A | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | UniProt NCBI |
| CCNE1 | G1/S-specific cyclin-E1 | UniProt NCBI |
| CDKN1C | Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2) | UniProt NCBI |
| CDK2 | Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase) | UniProt NCBI |
| CCNE2 | G1/S-specific cyclin-E2 | UniProt NCBI |
| RBL1 | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP179 | 8.09532151655e-12 | 1.0 | CCNE1 CDKN1C CDK2 CCNE2 RBL1 CDKN1A | Cell Cycle |
| KEGG:04110 | 1.11652254558e-11 | 1.0 | CCNE1 CDKN1C CDK2 CCNE2 RBL1 CDKN1A | Cell cycle |
| REAC:R-HSA-453279 | 1.36793220389e-10 | 1.0 | CCNE1 CDKN1C CDK2 CCNE2 RBL1 CDKN1A | Mitotic G1-G1/S phases |
| REAC:R-HSA-6791312 | 2.7527826922e-10 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | TP53 Regulates Transcription of Cell Cycle Genes |
| WP:WP45 | 2.84592842322e-10 | 0.833333333333 | CDK2 CCNE2 CDKN1A CDKN1C CCNE1 | G1 to S cell cycle control |
| REAC:R-HSA-6804116 | 1.19969130191e-09 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| WP:WP4658 | 2.3417535861e-09 | 0.833333333333 | CDK2 CCNE2 CDKN1A CDKN1C CCNE1 | Small cell lung cancer |
| REAC:R-HSA-1538133 | 2.10041615528e-08 | 0.666666666667 | CDK2 CCNE2 CCNE1 RBL1 | G0 and Early G1 |
| KEGG:04218 | 2.24952036407e-08 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | Cellular senescence |
| REAC:R-HSA-69200 | 2.3817666497e-08 | 0.5 | CCNE2 CCNE1 CDK2 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes |
| REAC:R-HSA-69206 | 4.58062236292e-08 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | G1/S Transition |
| KEGG:05203 | 8.35532103256e-08 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | Viral carcinogenesis |
| KEGG:04115 | 2.13897000955e-07 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | p53 signaling pathway |
| WP:WP707 | 2.30235692794e-07 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | DNA Damage Response |
| WP:WP1530 | 2.75328366404e-07 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | miRNA Regulation of DNA Damage Response |
| REAC:R-HSA-69278 | 2.75592746566e-07 | 1.0 | CCNE1 CDKN1C CDK2 CCNE2 RBL1 CDKN1A | Cell Cycle, Mitotic |
| WP:WP53 | 3.29800460256e-07 | 0.5 | CDK2 CCNE1 RBL1 | ID signaling pathway |
| REAC:R-HSA-187577 | 5.42829555401e-07 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | SCF(Skp2)-mediated degradation of p27/p21 |
| WP:WP2446 | 6.67174766457e-07 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Retinoblastoma Gene in Cancer |
| REAC:R-HSA-1640170 | 8.1733071499e-07 | 1.0 | CCNE1 CDKN1C CDK2 CCNE2 RBL1 CDKN1A | Cell Cycle |
| KEGG:05215 | 8.57786359503e-07 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Prostate cancer |
| REAC:R-HSA-69563 | 8.58955665617e-07 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | p53-Dependent G1 DNA Damage Response |
| REAC:R-HSA-69580 | 8.58955665617e-07 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | p53-Dependent G1/S DNA damage checkpoint |
| KEGG:05222 | 9.37805281521e-07 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Small cell lung cancer |
| REAC:R-HSA-69615 | 9.70376566633e-07 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | G1/S DNA Damage Checkpoints |
| KEGG:05165 | 1.06706538845e-06 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | Human papillomavirus infection |
| REAC:R-HSA-2559586 | 1.78817537458e-06 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | DNA Damage/Telomere Stress Induced Senescence |
| GO:0097134 | 1.81637152046e-06 | 0.5 | CCNE2 CCNE1 CDK2 | cyclin E1-CDK2 complex |
| REAC:R-HSA-69202 | 2.08093967041e-06 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-69656 | 2.29512356464e-06 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Cyclin A:Cdk2-associated events at S phase entry |
| KEGG:05226 | 3.91593140264e-06 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Gastric cancer |
| KEGG:04934 | 5.26734672914e-06 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Cushing syndrome |
| REAC:R-HSA-3700989 | 6.53130785078e-06 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | Transcriptional Regulation by TP53 |
| KEGG:05161 | 7.71045621645e-06 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Hepatitis B |
| CORUM:5560 | 8.39001385941e-06 | 0.333333333333 | CCNE1 CDK2 | CDK2-CCNE1 complex |
| WP:WP2516 | 1.36443750783e-05 | 0.5 | CDK2 CDKN1A CCNE1 | ATM Signaling Pathway |
| KEGG:05169 | 1.50261697698e-05 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Epstein-Barr virus infection |
| GO:0000307 | 1.90965027829e-05 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | cyclin-dependent protein kinase holoenzyme complex |
| KEGG:05166 | 2.01963878258e-05 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Human T-cell leukemia virus 1 infection |
| CORUM:1656 | 2.51655344529e-05 | 0.333333333333 | CCNE1 CDK2 | p27-cyclinE-CDK2 complex |
| CORUM:5159 | 2.51655344529e-05 | 0.333333333333 | CCNE1 RBL1 | E2F4-p107-cyclinE complex |
| REAC:R-HSA-69242 | 3.02487101892e-05 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | S Phase |
| CORUM:311 | 5.0322056017e-05 | 0.333333333333 | CDKN1A CDK2 | Cell cycle kinase complex CDK2 |
| REAC:R-HSA-2559583 | 5.92853293102e-05 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Cellular Senescence |
| REAC:R-HSA-69236 | 6.79649802247e-05 | 0.5 | CDKN1C CDKN1A RBL1 | G1 Phase |
| REAC:R-HSA-69231 | 6.79649802247e-05 | 0.5 | CDKN1C CDKN1A RBL1 | Cyclin D associated events in G1 |
| WP:WP4172 | 8.1191833253e-05 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | PI3K-Akt Signaling Pathway |
| KEGG:04151 | 0.00010854557604 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | PI3K-Akt signaling pathway |
| GO:0000082 | 0.000126408450622 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | G1/S transition of mitotic cell cycle |
| WP:WP2261 | 0.000131360147496 | 0.5 | CDK2 CDKN1A CCNE1 | Signaling Pathways in Glioblastoma |
| GO:0044843 | 0.000169291065803 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | cell cycle G1/S phase transition |
| REAC:R-HSA-8849470 | 0.000221597343492 | 0.333333333333 | CCNE1 CDK2 | PTK6 Regulates Cell Cycle |
| CORUM:3015 | 0.000234668084372 | 0.333333333333 | CCNE1 CDK2 | p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex |
| REAC:R-HSA-69620 | 0.000322105305692 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Cell Cycle Checkpoints |
| KEGG:04114 | 0.000328600438861 | 0.5 | CCNE2 CCNE1 CDK2 | Oocyte meiosis |
| REAC:R-HSA-69017 | 0.000336891436266 | 0.5 | CCNE2 CCNE1 CDK2 | CDK-mediated phosphorylation and removal of Cdc6 |
| GO:0000079 | 0.000352998651013 | 0.666666666667 | CCNE2 CDKN1A CDKN1C CCNE1 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO:1904029 | 0.000417891539136 | 0.666666666667 | CCNE2 CDKN1A CDKN1C CCNE1 | regulation of cyclin-dependent protein kinase activity |
| GO:1902554 | 0.000417891539136 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | serine/threonine protein kinase complex |
| WP:WP2877 | 0.000491125872978 | 0.5 | CDK2 CDKN1A CCNE1 | Vitamin D Receptor Pathway |
| MIRNA:hsa-miR-892b | 0.000503945500471 | 0.5 | CDK2 CCNE1 RBL1 | hsa-miR-892b |
| KEGG:05162 | 0.000563363106539 | 0.5 | CCNE2 CCNE1 CDK2 | Measles |
| WP:WP1545 | 0.000585450803921 | 0.333333333333 | CDKN1A CCNE1 | miRNAs involved in DNA damage response |
| KEGG:05200 | 0.000619708787865 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Pathways in cancer |
| REAC:R-HSA-69052 | 0.000667561375412 | 0.5 | CCNE2 CCNE1 CDK2 | Switching of origins to a post-replicative state |
| GO:1902911 | 0.00084563217517 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | protein kinase complex |
| KEGG:05206 | 0.00103954994556 | 0.5 | CCNE2 CDKN1A CCNE1 | MicroRNAs in cancer |
| REAC:R-HSA-2262752 | 0.00129372739211 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Cellular responses to stress |
| REAC:R-HSA-212436 | 0.00148146469319 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | Generic Transcription Pathway |
| GO:0000278 | 0.00149359264327 | 1.0 | CCNE1 CDKN1C CDK2 CCNE2 RBL1 CDKN1A | mitotic cell cycle |
| REAC:R-HSA-69239 | 0.00156211728615 | 0.5 | CCNE2 CCNE1 CDK2 | Synthesis of DNA |
| REAC:R-HSA-69306 | 0.00190266482243 | 0.5 | CCNE2 CCNE1 CDK2 | DNA Replication |
| GO:0051726 | 0.0023963010185 | 1.0 | CCNE1 CDKN1C CDK2 CCNE2 RBL1 CDKN1A | regulation of cell cycle |
| REAC:R-HSA-73857 | 0.00253857262834 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | RNA Polymerase II Transcription |
| REAC:R-HSA-8953897 | 0.00265671127538 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | Cellular responses to external stimuli |
| GO:2000045 | 0.0028699930952 | 0.666666666667 | CDK2 CDKN1A RBL1 CCNE1 | regulation of G1/S transition of mitotic cell cycle |
| HP:0006744 | 0.00337633448894 | 0.333333333333 | CDKN1C CDKN1A | Adrenocortical carcinoma |
| WP:WP2371 | 0.00349951078021 | 0.333333333333 | CCNE2 CCNE1 | Parkinsons Disease Pathway |
| WP:WP3941 | 0.00369881973951 | 0.333333333333 | CDKN1C CDKN1A | Oxidative Damage |
| GO:1902806 | 0.00410051335196 | 0.666666666667 | CDK2 CDKN1A RBL1 CCNE1 | regulation of cell cycle G1/S phase transition |
| REAC:R-HSA-74160 | 0.00435080618405 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | Gene expression (Transcription) |
| WP:WP2586 | 0.00477752328717 | 0.333333333333 | CDKN1A CDK2 | Aryl Hydrocarbon Receptor |
| GO:0019887 | 0.00491856836288 | 0.666666666667 | CCNE2 CDKN1A CDKN1C CCNE1 | protein kinase regulator activity |
| WP:WP1971 | 0.0050096749716 | 0.333333333333 | CDKN1A CDK2 | Integrated Cancer Pathway |
| WP:WP3611 | 0.00599288611144 | 0.333333333333 | CDKN1A CCNE1 | Photodynamic therapy-induced AP-1 survival signaling. |
| GO:0097135 | 0.00676235117068 | 0.333333333333 | CCNE2 CDK2 | cyclin E2-CDK2 complex |
| MIRNA:hsa-miR-524-5p | 0.00694853153834 | 0.5 | CCNE2 CCNE1 CDK2 | hsa-miR-524-5p |
| REAC:R-HSA-69205 | 0.00834193552282 | 0.333333333333 | CCNE1 RBL1 | G1/S-Specific Transcription |
| GO:0044772 | 0.00886141193647 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | mitotic cell cycle phase transition |
| GO:0019207 | 0.0089947338343 | 0.666666666667 | CCNE2 CDKN1A CDKN1C CCNE1 | kinase regulator activity |
| WP:WP2572 | 0.0107960863784 | 0.333333333333 | CDKN1C CDKN1A | Primary Focal Segmental Glomerulosclerosis FSGS |
| HP:0100641 | 0.0114630974264 | 0.333333333333 | CDKN1C CDKN1A | Neoplasm of the adrenal cortex |
| WP:WP2032 | 0.0114940114472 | 0.333333333333 | CCNE1 CDK2 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| GO:0044770 | 0.0121980983176 | 0.833333333333 | CDK2 CCNE2 CDKN1A RBL1 CCNE1 | cell cycle phase transition |
| GO:0016538 | 0.0140408309691 | 0.5 | CCNE2 CDKN1A CCNE1 | cyclin-dependent protein serine/threonine kinase regulator activity |
| GO:0007346 | 0.0142745150705 | 0.833333333333 | CDK2 CDKN1C CDKN1A RBL1 CCNE1 | regulation of mitotic cell cycle |
| REAC:R-HSA-390471 | 0.0154864524203 | 0.333333333333 | CCNE2 CCNE1 | Association of TriC/CCT with target proteins during biosynthesis |
| MIRNA:hsa-miR-646 | 0.0194935276219 | 0.5 | CCNE2 CCNE1 RBL1 | hsa-miR-646 |
| MIRNA:hsa-miR-144-5p | 0.0195096328216 | 0.333333333333 | CCNE2 CCNE1 | hsa-miR-144-5p |
| MIRNA:hsa-miR-503-5p | 0.0197515874976 | 0.5 | CCNE2 CDKN1A CCNE1 | hsa-miR-503-5p |
| WP:WP138 | 0.021066272601 | 0.333333333333 | CDKN1A CCNE1 | Androgen receptor signaling pathway |
| GO:0007049 | 0.0218766736595 | 1.0 | CCNE1 CDKN1C CDK2 CCNE2 RBL1 CDKN1A | cell cycle |
| REAC:R-HSA-9006927 | 0.0227674337622 | 0.333333333333 | CCNE1 CDK2 | Signaling by Non-Receptor Tyrosine Kinases |
| REAC:R-HSA-8848021 | 0.0227674337622 | 0.333333333333 | CCNE1 CDK2 | Signaling by PTK6 |
| GO:0043549 | 0.0251365491115 | 0.833333333333 | CCNE2 RBL1 CDKN1A CDKN1C CCNE1 | regulation of kinase activity |
| HP:0100631 | 0.030358517586 | 0.333333333333 | CDKN1C CDKN1A | Neoplasm of the adrenal gland |
| MIRNA:hsa-miR-6802-5p | 0.0322018359422 | 0.333333333333 | CDKN1A CDK2 | hsa-miR-6802-5p |
| WP:WP236 | 0.032861644993 | 0.333333333333 | CDKN1A RBL1 | Adipogenesis |
| WP:WP4284 | 0.0332875339197 | 0.166666666667 | CCNE2 | Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer |
| GO:0061695 | 0.0358414221529 | 0.666666666667 | CDK2 CCNE2 CDKN1A CCNE1 | transferase complex, transferring phosphorus-containing groups |
| KEGG:04068 | 0.039527830217 | 0.333333333333 | CDKN1A CDK2 | FoxO signaling pathway |
| WP:WP366 | 0.0416969783243 | 0.333333333333 | CDKN1A RBL1 | TGF-beta Signaling Pathway |
| CORUM:5556 | 0.0499726005494 | 0.166666666667 | CDK2 | CDK2-CCNA2 complex |
| CORUM:314 | 0.0499726005494 | 0.166666666667 | CDKN1A | PCNA-p21 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CCNE1 | CDK2 | 1.0 | 0.949 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2) |
| CDK2 | CDKN1C | 0.998 | 0.941 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2) |
| CDKN1A | CCNE2 | 0.996 | 0.927 | hein_WMM bioplex (CCNE2) bioplex_WMM hein (CDKN1A) |
| CDK2 | CCNE2 | 0.992 | 0.915 | hein_WMM bioplex (CCNE2,CDK2) bioplex_WMM hein (CDK2) |
| RBL1 | CDK2 | 0.988 | 0.902 | bioplex (CDK2) bioplex_WMM boldt boldt_WMM |
| CDK2 | CDKN1A | 0.971 | 0.882 | hein_WMM bioplex (CDK2) bioplex_WMM hein (CDK2,CDKN1A) |
| CDKN1A | CDKN1C | 0.029 | 0.233 | hein_WMM bioplex_WMM WMM_only |
| CCNE1 | CCNE2 | 0.017 | 0.173 | hein_WMM bioplex_WMM WMM_only |
| CCNE1 | CDKN1A | 0.012 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| CCNE1 | CDKN1C | 0.01 | 0.117 | hein_WMM bioplex_WMM WMM_only |
| CDKN1C | CCNE2 | 0.01 | 0.12 | hein_WMM bioplex_WMM WMM_only |
| RBL1 | CDKN1C | 0.008 | 0.089 | bioplex_WMM WMM_only |
| RBL1 | CDKN1A | 0.008 | 0.06 | bioplex_WMM WMM_only |
| RBL1 | CCNE2 | 0.008 | 0.031 | bioplex_WMM WMM_only |
| CCNE1 | RBL1 | 0.008 | 0.024 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04287 has an average edge precision of 0.434 which is ranked 2980 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDKN1A | HuMAP2_03511 HuMAP2_04287 HuMAP2_05212 HuMAP2_06056 |
| CCNE1 | HuMAP2_01003 HuMAP2_04287 HuMAP2_05212 HuMAP2_05263 HuMAP2_06689 |
| CDKN1C | HuMAP2_03511 HuMAP2_04287 HuMAP2_05212 HuMAP2_06056 |
| CDK2 | HuMAP2_01003 HuMAP2_04287 HuMAP2_05212 HuMAP2_05263 HuMAP2_06056 HuMAP2_06689 |
| CCNE2 | HuMAP2_04287 HuMAP2_05212 HuMAP2_05263 HuMAP2_06056 |
| RBL1 | HuMAP2_01003 HuMAP2_02530 HuMAP2_04287 HuMAP2_06056 |