hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04291
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLC52A2 | Solute carrier family 52, riboflavin transporter, member 2 (Porcine endogenous retrovirus A receptor 1) (PERV-A receptor 1) (Protein GPR172A) (Riboflavin transporter 3) (hRFT3) | UniProt NCBI |
| UPK1A | Uroplakin-1a (UP1a) (Tetraspanin-21) (Tspan-21) (Uroplakin Ia) (UPIa) (UPKa) | UniProt NCBI |
| SLC49A4 | Solute carrier family 49 member 4 (Disrupted in renal cancer protein 2) (Disrupted in renal carcinoma protein 2) | UniProt NCBI |
| TUSC3 | Tumor suppressor candidate 3 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3) (Oligosaccharyl transferase subunit TUSC3) (Magnesium uptake/transporter TUSC3) (Protein N33) | UniProt NCBI |
| TMEM222 | Transmembrane protein 222 | UniProt NCBI |
| SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) | UniProt NCBI |
| FZD8 | Frizzled-8 (Fz-8) (hFz8) | UniProt NCBI |
| FZD7 | Frizzled-7 (Fz-7) (hFz7) (FzE3) | UniProt NCBI |
| TMEM62 | Transmembrane protein 62 | UniProt NCBI |
| FZD3 | Frizzled-3 (Fz-3) (hFz3) | UniProt NCBI |
| FZD1 | Frizzled-1 (Fz-1) (hFz1) (FzE1) | UniProt NCBI |
| FZD2 | Frizzled-2 (Fz-2) (hFz2) (FzE2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4150 | 2.4023067628e-09 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Wnt Signaling in Kidney Disease |
| GO:0042813 | 1.29432526962e-08 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Wnt-activated receptor activity |
| KEGG:05217 | 2.2083686193e-08 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Basal cell carcinoma |
| WP:WP4239 | 2.94904294413e-08 | 0.5 | FZD3 FZD7 FZD8 FZD2 TUSC3 FZD1 | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP3680 | 5.99960701052e-08 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| GO:0017147 | 1.69720350747e-07 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Wnt-protein binding |
| WP:WP4336 | 1.79138482452e-07 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| REAC:R-HSA-373080 | 1.98334995958e-07 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Class B/2 (Secretin family receptors) |
| REAC:R-HSA-4608870 | 2.15348212986e-07 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Asymmetric localization of PCP proteins |
| KEGG:04916 | 2.36877388225e-07 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Melanogenesis |
| WP:WP4258 | 3.12430807798e-07 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| WP:WP399 | 5.42785862832e-07 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Wnt Signaling Pathway and Pluripotency |
| WP:WP3931 | 5.71742849926e-07 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | ESC Pluripotency Pathways |
| WP:WP428 | 8.9184868246e-07 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Wnt Signaling |
| KEGG:04550 | 1.21668875017e-06 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Signaling pathways regulating pluripotency of stem cells |
| REAC:R-HSA-4086400 | 1.40919393063e-06 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | PCP/CE pathway |
| KEGG:05224 | 1.60738633055e-06 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Breast cancer |
| KEGG:05226 | 1.67051294958e-06 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Gastric cancer |
| KEGG:04934 | 2.4170254098e-06 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Cushing syndrome |
| KEGG:04390 | 2.50425028132e-06 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Hippo signaling pathway |
| KEGG:04150 | 2.68620916236e-06 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | mTOR signaling pathway |
| KEGG:04310 | 2.97871288784e-06 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Wnt signaling pathway |
| WP:WP4262 | 3.3308349758e-06 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Breast cancer pathway |
| KEGG:05225 | 4.41210500439e-06 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Hepatocellular carcinoma |
| KEGG:05205 | 1.01803719549e-05 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Proteoglycans in cancer |
| REAC:R-HSA-3858494 | 1.11167184332e-05 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Beta-catenin independent WNT signaling |
| WP:WP3664 | 1.8170226447e-05 | 0.25 | FZD1 FZD8 FZD7 | Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds |
| GO:0030165 | 1.82712286534e-05 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | PDZ domain binding |
| REAC:R-HSA-500792 | 9.15965354976e-05 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | GPCR ligand binding |
| KEGG:05165 | 0.00012465329725 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Human papillomavirus infection |
| REAC:R-HSA-195721 | 0.000641824306861 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Signaling by WNT |
| KEGG:05200 | 0.000871579882912 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Pathways in cancer |
| GO:0035567 | 0.00183756424453 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | non-canonical Wnt signaling pathway |
| REAC:R-HSA-372790 | 0.0138578897419 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | Signaling by GPCR |
| GO:0060071 | 0.0297342072081 | 0.333333333333 | FZD2 FZD1 FZD7 FZD3 | Wnt signaling pathway, planar cell polarity pathway |
| GO:0090175 | 0.0310878855559 | 0.333333333333 | FZD2 FZD1 FZD7 FZD3 | regulation of establishment of planar polarity |
| GO:0007164 | 0.0385570273988 | 0.333333333333 | FZD2 FZD1 FZD7 FZD3 | establishment of tissue polarity |
| GO:0001736 | 0.0385570273988 | 0.333333333333 | FZD2 FZD1 FZD7 FZD3 | establishment of planar polarity |
| GO:0060070 | 0.0460490785935 | 0.416666666667 | FZD3 FZD2 FZD1 FZD8 FZD7 | canonical Wnt signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UPK1A | FZD1 | 0.088 | 0.354 | bioplex (UPK1A) bioplex_WMM |
| SLC6A9 | UPK1A | 0.075 | 0.356 | bioplex (UPK1A) bioplex_WMM |
| UPK1A | FZD3 | 0.038 | 0.262 | bioplex (UPK1A) bioplex_WMM |
| UPK1A | TMEM62 | 0.03 | 0.235 | bioplex (UPK1A) bioplex_WMM |
| UPK1A | FZD2 | 0.029 | 0.23 | bioplex (UPK1A) bioplex_WMM |
| UPK1A | SLC49A4 | 0.027 | 0.23 | bioplex (UPK1A) bioplex_WMM |
| UPK1A | FZD7 | 0.024 | 0.216 | bioplex (UPK1A) bioplex_WMM |
| UPK1A | FZD8 | 0.024 | 0.214 | bioplex (UPK1A) bioplex_WMM |
| UPK1A | TMEM222 | 0.021 | 0.194 | bioplex (UPK1A) bioplex_WMM |
| UPK1A | SLC52A2 | 0.021 | 0.189 | bioplex (UPK1A) bioplex_WMM |
| UPK1A | TUSC3 | 0.02 | 0.186 | bioplex (UPK1A) bioplex_WMM |
| FZD7 | FZD2 | 0.011 | 0.142 | bioplex_WMM WMM_only |
| SLC49A4 | FZD7 | 0.009 | 0.114 | bioplex_WMM WMM_only |
| FZD3 | FZD2 | 0.009 | 0.106 | bioplex_WMM WMM_only |
| SLC6A9 | FZD1 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SLC6A9 | SLC49A4 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| FZD1 | SLC49A4 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| FZD1 | SLC52A2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SLC6A9 | SLC52A2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SLC6A9 | TMEM62 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| FZD1 | TMEM62 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| FZD1 | FZD8 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| SLC6A9 | FZD8 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| SLC49A4 | TMEM62 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| SLC52A2 | TMEM62 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| SLC52A2 | SLC49A4 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| FZD1 | TMEM222 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| SLC6A9 | TMEM222 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| SLC49A4 | FZD2 | 0.008 | 0.079 | bioplex_WMM WMM_only |
| FZD7 | FZD3 | 0.008 | 0.076 | bioplex_WMM WMM_only |
| FZD8 | TMEM62 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SLC52A2 | FZD8 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SLC49A4 | FZD8 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SLC6A9 | FZD7 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| FZD1 | FZD7 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SLC49A4 | TMEM222 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| TMEM62 | TMEM222 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SLC52A2 | TMEM222 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| FZD1 | FZD3 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SLC6A9 | FZD3 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| TUSC3 | FZD3 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SLC52A2 | FZD7 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| FZD8 | TMEM222 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| FZD7 | TMEM62 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| FZD1 | TUSC3 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| SLC6A9 | TUSC3 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| SLC52A2 | FZD3 | 0.008 | 0.026 | bioplex_WMM WMM_only |
| TMEM62 | FZD3 | 0.008 | 0.026 | bioplex_WMM WMM_only |
| SLC49A4 | FZD3 | 0.008 | 0.026 | bioplex_WMM WMM_only |
| FZD8 | FZD7 | 0.008 | 0.025 | bioplex_WMM WMM_only |
| FZD7 | TMEM222 | 0.008 | 0.011 | bioplex_WMM WMM_only |
| FZD8 | FZD3 | 0.008 | 0.011 | bioplex_WMM WMM_only |
| TUSC3 | SLC49A4 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| TUSC3 | TMEM62 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| TUSC3 | SLC52A2 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| SLC6A9 | FZD2 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| FZD1 | FZD2 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| FZD3 | TMEM222 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| TUSC3 | FZD8 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| TUSC3 | TMEM222 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| SLC52A2 | FZD2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| TMEM62 | FZD2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| TUSC3 | FZD7 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| FZD8 | FZD2 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| TUSC3 | FZD2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| TMEM222 | FZD2 | 0.007 | 0.001 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04291 has an average edge precision of 0.083 which is ranked 6961 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SLC52A2 | HuMAP2_02002 HuMAP2_04291 |
| UPK1A | HuMAP2_00973 HuMAP2_04291 |
| SLC49A4 | HuMAP2_04031 HuMAP2_04291 |
| TUSC3 | HuMAP2_01427 HuMAP2_04291 HuMAP2_06869 |
| TMEM222 | HuMAP2_04291 |
| SLC6A9 | HuMAP2_00973 HuMAP2_04291 |
| FZD8 | HuMAP2_04291 |
| FZD7 | HuMAP2_04291 |
| TMEM62 | HuMAP2_04291 |
| FZD3 | HuMAP2_04291 |
| FZD1 | HuMAP2_00973 HuMAP2_04291 |
| FZD2 | HuMAP2_04291 |