hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04294
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RNF7 | RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) | UniProt NCBI |
| ELOC | Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1) | UniProt NCBI |
| ELOB | Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2) | UniProt NCBI |
| ASB9 | Ankyrin repeat and SOCS box protein 9 (ASB-9) | UniProt NCBI |
| NUP37 | Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:211 | 5.40532307664e-09 | 0.6 | ELOC RNF7 ELOB | Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:6268 | 5.40532307664e-09 | 0.6 | ELOC ASB9 ELOB | Cullin-RING E3 ubiquitin ligase complex |
| CORUM:210 | 1.35119464053e-08 | 0.6 | ELOC RNF7 ELOB | Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:207 | 1.35119464053e-08 | 0.6 | ELOC RNF7 ELOB | Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:209 | 1.35119464053e-08 | 0.6 | ELOC RNF7 ELOB | Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:208 | 1.35119464053e-08 | 0.6 | ELOC RNF7 ELOB | Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7) |
| CORUM:7576 | 2.0123342217e-05 | 0.4 | ELOC ELOB | VHL-ElonginB-ElonginC complex |
| CORUM:6738 | 2.0123342217e-05 | 0.4 | ELOC ELOB | PRAME-ElonginBC ubiquitin ligase |
| CORUM:5270 | 2.0123342217e-05 | 0.4 | ELOC ELOB | VHL-TCEB1-TCEB2 complex |
| REAC:R-HSA-8951664 | 3.55482668831e-05 | 0.8 | ELOC RNF7 ELOB ASB9 | Neddylation |
| CORUM:5267 | 4.0241279111e-05 | 0.4 | ELOC ELOB | VHL-VDU1-TCEB1-TCEB2 complex |
| CORUM:622 | 4.0241279111e-05 | 0.4 | ELOC ELOB | Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2) |
| CORUM:6485 | 4.0241279111e-05 | 0.4 | ELOC ELOB | HIF1alpha-VHL-ElonginB-ElonginC complex |
| CORUM:214 | 6.7059790554e-05 | 0.4 | ELOC ELOB | Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1) |
| CORUM:205 | 6.7059790554e-05 | 0.4 | ELOC ELOB | Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) |
| WP:WP3300 | 9.3428788144e-05 | 0.4 | ELOC ELOB | Dual hijack model of Vif in HIV infection |
| REAC:R-HSA-983168 | 0.000106689631566 | 0.8 | ELOC RNF7 ELOB ASB9 | Antigen processing: Ubiquitination & Proteasome degradation |
| CORUM:7556 | 0.000140787732431 | 0.4 | ELOC ELOB | PRAME complex |
| REAC:R-HSA-983169 | 0.000217774869126 | 0.8 | ELOC RNF7 ELOB ASB9 | Class I MHC mediated antigen processing & presentation |
| KEGG:04120 | 0.000305495250573 | 0.6 | ELOC RNF7 ELOB | Ubiquitin mediated proteolysis |
| REAC:R-HSA-597592 | 0.000641406598892 | 1.0 | ELOC NUP37 RNF7 ELOB ASB9 | Post-translational protein modification |
| REAC:R-HSA-162909 | 0.000793200049211 | 0.6 | NUP37 ELOB ELOC | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 0.00102865345201 | 0.6 | NUP37 ELOB ELOC | Late Phase of HIV Life Cycle |
| KEGG:05170 | 0.00109699385517 | 0.6 | ELOC RNF7 ELOB | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-162587 | 0.00136170542712 | 0.6 | NUP37 ELOB ELOC | HIV Life Cycle |
| WP:WP4241 | 0.00144719807027 | 0.4 | ELOC ELOB | Type 2 papillary renal cell carcinoma |
| REAC:R-HSA-1280218 | 0.00256626643698 | 0.8 | ELOC RNF7 ELOB ASB9 | Adaptive Immune System |
| REAC:R-HSA-168256 | 0.00339317023665 | 1.0 | ELOC NUP37 RNF7 ELOB ASB9 | Immune System |
| REAC:R-HSA-392499 | 0.0039377533293 | 1.0 | ELOC NUP37 RNF7 ELOB ASB9 | Metabolism of proteins |
| REAC:R-HSA-162906 | 0.00484900153486 | 0.6 | NUP37 ELOB ELOC | HIV Infection |
| REAC:R-HSA-167238 | 0.00666792835349 | 0.4 | ELOC ELOB | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-167243 | 0.00666792835349 | 0.4 | ELOC ELOB | Tat-mediated HIV elongation arrest and recovery |
| GO:0032446 | 0.00732992354676 | 1.0 | ELOC NUP37 RNF7 ELOB ASB9 | protein modification by small protein conjugation |
| REAC:R-HSA-167290 | 0.0075397219523 | 0.4 | ELOC ELOB | Pausing and recovery of HIV elongation |
| REAC:R-HSA-167287 | 0.0075397219523 | 0.4 | ELOC ELOB | HIV elongation arrest and recovery |
| KEGG:05211 | 0.00831682765542 | 0.4 | ELOC ELOB | Renal cell carcinoma |
| REAC:R-HSA-167246 | 0.0126969553517 | 0.4 | ELOC ELOB | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167200 | 0.0126969553517 | 0.4 | ELOC ELOB | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167169 | 0.0126969553517 | 0.4 | ELOC ELOB | HIV Transcription Elongation |
| GO:0070449 | 0.0135228859698 | 0.4 | ELOC ELOB | elongin complex |
| REAC:R-HSA-167152 | 0.0138877528683 | 0.4 | ELOC ELOB | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-180585 | 0.0184727645209 | 0.4 | ELOC ELOB | Vif-mediated degradation of APOBEC3G |
| REAC:R-HSA-5663205 | 0.0198891654246 | 0.6 | NUP37 ELOB ELOC | Infectious disease |
| KEGG:04066 | 0.020974746694 | 0.4 | ELOC ELOB | HIF-1 signaling pathway |
| REAC:R-HSA-75955 | 0.0229182830201 | 0.4 | ELOC ELOB | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 0.0229182830201 | 0.4 | ELOC ELOB | Formation of RNA Pol II elongation complex |
| GO:0070647 | 0.023802724014 | 1.0 | ELOC NUP37 RNF7 ELOB ASB9 | protein modification by small protein conjugation or removal |
| REAC:R-HSA-6796648 | 0.0253191001807 | 0.4 | ELOC ELOB | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-1234176 | 0.0278384291304 | 0.4 | ELOC ELOB | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| REAC:R-HSA-2262752 | 0.0291077226575 | 0.6 | NUP37 ELOB ELOC | Cellular responses to stress |
| REAC:R-HSA-167172 | 0.0332320424718 | 0.4 | ELOC ELOB | Transcription of the HIV genome |
| REAC:R-HSA-1234174 | 0.0361060371214 | 0.4 | ELOC ELOB | Cellular response to hypoxia |
| REAC:R-HSA-674695 | 0.0443461879505 | 0.4 | ELOC ELOB | RNA Polymerase II Pre-transcription Events |
| CORUM:0000000 | 0.0474603483533 | 1.0 | ELOC NUP37 RNF7 ELOB ASB9 | CORUM root |
| REAC:R-HSA-8953897 | 0.0498194225693 | 0.6 | NUP37 ELOB ELOC | Cellular responses to external stimuli |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ELOC | ELOB | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (ELOC) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| ELOC | ASB9 | 0.57 | 0.656 | bioplex (ASB9) bioplex_WMM |
| ELOB | ASB9 | 0.049 | 0.294 | bioplex (ASB9) bioplex_WMM |
| NUP37 | ELOB | 0.037 | 0.265 | fraction |
| ASB9 | RNF7 | 0.033 | 0.253 | bioplex (ASB9) bioplex_WMM |
| NUP37 | ELOC | 0.03 | 0.235 | fraction |
| ELOC | RNF7 | 0.009 | 0.105 | bioplex_WMM WMM_only |
| ELOB | RNF7 | 0.009 | 0.106 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04294 has an average edge precision of 0.358 which is ranked 3795 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RNF7 | HuMAP2_03005 HuMAP2_04294 |
| ELOC | HuMAP2_00596 HuMAP2_04294 HuMAP2_05478 HuMAP2_05583 HuMAP2_05603 |
| ELOB | HuMAP2_00596 HuMAP2_04294 HuMAP2_05583 |
| ASB9 | HuMAP2_01001 HuMAP2_01415 HuMAP2_04294 HuMAP2_05583 HuMAP2_05603 |
| NUP37 | HuMAP2_00541 HuMAP2_03792 HuMAP2_04294 HuMAP2_05315 |