hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04304

Confidence: Medium

Genename	Protein Name	Links
DDR1	Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)	UniProt NCBI
TNFRSF10B	Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)	UniProt NCBI
IL37	Interleukin-37 (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1) (Interleukin-23) (IL-37)	UniProt NCBI
FAS	Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)	UniProt NCBI
TNFRSF10A	Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)	UniProt NCBI
FADD	FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) (Protein FADD)	UniProt NCBI
RNF149	E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149)	UniProt NCBI
LSS	Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC)	UniProt NCBI
CASP8	Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]	UniProt NCBI
FAM118B	Protein FAM118B	UniProt NCBI
UGCG	Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5218900	2.08872026269e-12	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	CASP8 activity is inhibited
REAC:R-HSA-3371378	2.08872026269e-12	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Regulation by c-FLIP
REAC:R-HSA-69416	2.08872026269e-12	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Dimerization of procaspase-8
REAC:R-HSA-140534	2.1306133965e-11	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Caspase activation via Death Receptors in the presence of ligand
REAC:R-HSA-5675482	7.22388695951e-11	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Regulation of necroptotic cell death
REAC:R-HSA-5218859	1.4160411413e-10	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Regulated Necrosis
REAC:R-HSA-5213460	1.4160411413e-10	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	RIPK1-mediated regulated necrosis
REAC:R-HSA-5357769	4.34639672163e-10	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Caspase activation via extrinsic apoptotic signalling pathway
REAC:R-HSA-75158	1.23443389486e-09	0.363636363636	TNFRSF10A CASP8 TNFRSF10B FADD	TRAIL signaling
CORUM:5473	2.02774899104e-08	0.272727272727	FAS CASP8 FADD	DISC complex (FAS, FADD, CASP8)
CORUM:5800	2.02774899104e-08	0.272727272727	FAS CASP8 FADD	DISC complex (FAS, FADD, CASP8)
CORUM:5860	2.02774899104e-08	0.272727272727	FAS CASP8 FADD	DISC complex (FAS, FADD, CASP8)
CORUM:5799	8.10772781726e-08	0.272727272727	FAS CASP8 FADD	DISC complex (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced
CORUM:5859	8.10772781726e-08	0.272727272727	FAS CASP8 FADD	FAS-FADD-CASP8-CASP10 complex
WP:WP1772	1.2790391807e-07	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Apoptosis Modulation and Signaling
GO:1902042	3.69093585197e-07	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0036462	5.62690127955e-07	0.363636363636	TNFRSF10A CASP8 TNFRSF10B FADD	TRAIL-activated apoptotic signaling pathway
REAC:R-HSA-75157	6.56710154024e-07	0.272727272727	FAS CASP8 FADD	FasL/ CD95L signaling
KEGG:04210	7.67982906387e-07	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Apoptosis
GO:0071260	1.41200114943e-06	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	cellular response to mechanical stimulus
KEGG:05164	1.79579098611e-06	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Influenza A
KEGG:04217	2.05288974958e-06	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Necroptosis
GO:1902041	2.15428850668e-06	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	regulation of extrinsic apoptotic signaling pathway via death domain receptors
REAC:R-HSA-73887	3.89204764887e-06	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Death Receptor Signalling
KEGG:05130	4.39997795969e-06	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Pathogenic Escherichia coli infection
REAC:R-HSA-6803211	7.86465652313e-06	0.272727272727	TNFRSF10A FAS TNFRSF10B	TP53 Regulates Transcription of Death Receptors and Ligands
WP:WP254	1.15529575866e-05	0.363636363636	FAS CASP8 TNFRSF10B FADD	Apoptosis
GO:0008625	1.55721148271e-05	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	extrinsic apoptotic signaling pathway via death domain receptors
WP:WP384	1.64466893663e-05	0.272727272727	FAS CASP8 FADD	Apoptosis Modulation by HSP70
REAC:R-HSA-109581	1.69980916811e-05	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Apoptosis
REAC:R-HSA-5357801	1.85619694491e-05	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	Programmed Cell Death
WP:WP2507	1.95225710949e-05	0.272727272727	FAS CASP8 FADD	Nanomaterial induced apoptosis
GO:2001237	3.06364005417e-05	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	negative regulation of extrinsic apoptotic signaling pathway
CORUM:5808	3.35524866385e-05	0.181818181818	CASP8 FADD	DISC complex (CD95, FADD, CASP8)
GO:0006919	3.8624638418e-05	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0009612	4.48152268518e-05	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	response to mechanical stimulus
KEGG:04061	9.51164370968e-05	0.272727272727	TNFRSF10A TNFRSF10B IL37	Viral protein interaction with cytokine and cytokine receptor
CORUM:6414	0.000100616904936	0.181818181818	CASP8 FADD	RIPK1-FADD-caspase-8 complex
CORUM:5991	0.000100616904936	0.181818181818	CASP8 FADD	LRRK2-FADD-CASP8 complex
CORUM:5798	0.000100616904936	0.181818181818	CASP8 FADD	Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced
CORUM:5861	0.000100616904936	0.181818181818	FADD FAS	FAS-FADD-CASP10 complex
GO:0031265	0.000149729915117	0.272727272727	FAS CASP8 FADD	CD95 death-inducing signaling complex
GO:2001236	0.000170982774628	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	regulation of extrinsic apoptotic signaling pathway
KEGG:04060	0.000179804175248	0.363636363636	IL37 TNFRSF10A FAS TNFRSF10B	Cytokine-cytokine receptor interaction
CORUM:2054	0.000201152732593	0.181818181818	CASP8 FADD	CASP8-FADD-MALT1-BCL10 complex
WP:WP314	0.000229153578705	0.272727272727	FAS CASP8 FADD	Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
GO:0043280	0.000249098765969	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001056	0.000512260820572	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	positive regulation of cysteine-type endopeptidase activity
KEGG:04115	0.000548796755159	0.272727272727	CASP8 TNFRSF10B FAS	p53 signaling pathway
REAC:R-HSA-5633008	0.000639737329157	0.272727272727	TNFRSF10A FAS TNFRSF10B	TP53 Regulates Transcription of Cell Death Genes
KEGG:01524	0.000783042970688	0.272727272727	FAS CASP8 FADD	Platinum drug resistance
GO:0031264	0.000837474301274	0.272727272727	FAS CASP8 FADD	death-inducing signaling complex
WP:WP707	0.0009466381717	0.272727272727	CASP8 TNFRSF10B FAS	DNA Damage Response
GO:0010950	0.000999055446036	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	positive regulation of endopeptidase activity
WP:WP1530	0.00108039353038	0.272727272727	CASP8 TNFRSF10B FAS	miRNA Regulation of DNA Damage Response
GO:0097191	0.00125591579253	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	extrinsic apoptotic signaling pathway
GO:0010952	0.0013034109101	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	positive regulation of peptidase activity
KEGG:05142	0.00143149873601	0.272727272727	FAS CASP8 FADD	Chagas disease (American trypanosomiasis)
WP:WP2059	0.00161504274681	0.272727272727	FAS CASP8 FADD	Alzheimers Disease
REAC:R-HSA-9013957	0.0016286415525	0.181818181818	CASP8 FADD	TLR3-mediated TICAM1-dependent programmed cell death
GO:2001234	0.00167740124483	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	negative regulation of apoptotic signaling pathway
KEGG:04668	0.00168937321993	0.272727272727	FAS CASP8 FADD	TNF signaling pathway
GO:0043281	0.00199332799458	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	regulation of cysteine-type endopeptidase activity involved in apoptotic process
KEGG:04650	0.00203701253642	0.272727272727	TNFRSF10A FAS TNFRSF10B	Natural killer cell mediated cytotoxicity
WP:WP2513	0.00220555818369	0.181818181818	CASP8 FADD	Nanoparticle triggered regulated necrosis
REAC:R-HSA-2562578	0.00303768164914	0.181818181818	CASP8 FADD	TRIF-mediated programmed cell death
GO:2000116	0.00376217656039	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	regulation of cysteine-type endopeptidase activity
KEGG:05162	0.00438181803449	0.272727272727	FAS CASP8 FADD	Measles
GO:0071496	0.00502342936257	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	cellular response to external stimulus
KEGG:05160	0.00524617280467	0.272727272727	FAS CASP8 FADD	Hepatitis C
REAC:R-HSA-933543	0.00714871709538	0.181818181818	CASP8 FADD	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
REAC:R-HSA-5357786	0.00714871709538	0.181818181818	CASP8 FADD	TNFR1-induced proapoptotic signaling
KEGG:05010	0.00758155968524	0.272727272727	FAS CASP8 FADD	Alzheimer disease
WP:WP3982	0.00768840827082	0.181818181818	CASP8 TNFRSF10B	miRNA regulation of p53 pathway in prostate cancer
KEGG:05161	0.00772806811947	0.272727272727	FAS CASP8 FADD	Hepatitis B
GO:0104004	0.00876378958937	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	cellular response to environmental stimulus
GO:0071214	0.00876378958937	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	cellular response to abiotic stimulus
KEGG:05167	0.00929576135653	0.272727272727	FAS CASP8 FADD	Kaposi sarcoma-associated herpesvirus infection
WP:WP4666	0.00952860285802	0.272727272727	FAS CASP8 FADD	Hepatitis B infection
KEGG:04215	0.00960804604595	0.181818181818	CASP8 FADD	Apoptosis - multiple species
KEGG:05169	0.0126126378001	0.272727272727	FAS CASP8 FADD	Epstein-Barr virus infection
KEGG:05170	0.0161352260373	0.272727272727	FAS CASP8 FADD	Human immunodeficiency virus 1 infection
KEGG:05163	0.0168593245035	0.272727272727	FAS CASP8 FADD	Human cytomegalovirus infection
GO:0052548	0.0222444031943	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	regulation of endopeptidase activity
GO:0045569	0.0247952876258	0.181818181818	TNFRSF10B TNFRSF10A	TRAIL binding
WP:WP2036	0.0257732296968	0.181818181818	CASP8 FADD	TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
GO:2001233	0.0266990304777	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	regulation of apoptotic signaling pathway
GO:0052547	0.0324491134709	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	regulation of peptidase activity
GO:0045862	0.0337086388398	0.454545454545	FAS TNFRSF10A CASP8 TNFRSF10B FADD	positive regulation of proteolysis
KEGG:04622	0.043922391756	0.181818181818	CASP8 FADD	RIG-I-like receptor signaling pathway
WP:WP3865	0.0470179536881	0.181818181818	CASP8 FADD	Novel intracellular components of RIG-I-like receptor (RLR) pathway
GO:0070266	0.0485987949639	0.272727272727	FAS CASP8 FADD	necroptotic process
CORUM:6158	0.0499697183507	0.0909090909091	TNFRSF10B	TRIAL-DR5 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
FADD	IL37	0.528	0.633	bioplex (FADD) bioplex_WMM
CASP8	TNFRSF10B	0.268	0.482	bioplex (TNFRSF10B) bioplex_WMM
FADD	TNFRSF10B	0.244	0.468	bioplex (TNFRSF10B) bioplex_WMM
CASP8	TNFRSF10A	0.126	0.4	bioplex (TNFRSF10A) bioplex_WMM
FAS	FADD	0.075	0.357	bioplex (FAS) bioplex_WMM
FAS	FAM118B	0.07	0.348	bioplex (FAM118B,FAS) bioplex_WMM
UGCG	TNFRSF10B	0.059	0.328	bioplex (TNFRSF10B) bioplex_WMM
FADD	TNFRSF10A	0.053	0.298	bioplex (TNFRSF10A) bioplex_WMM
FAS	CASP8	0.052	0.301	bioplex (FAS) bioplex_WMM
RNF149	TNFRSF10B	0.035	0.26	bioplex (TNFRSF10B) bioplex_WMM
DDR1	TNFRSF10B	0.035	0.266	bioplex (TNFRSF10B) bioplex_WMM
LSS	TNFRSF10A	0.026	0.216	bioplex (TNFRSF10A) bioplex_WMM
TNFRSF10B	TNFRSF10A	0.019	0.186	bioplex (TNFRSF10A) bioplex_WMM
UGCG	TNFRSF10A	0.016	0.165	bioplex (TNFRSF10A) bioplex_WMM
CASP8	FADD	0.013	0.15	bioplex_WMM WMM_only
RNF149	UGCG	0.012	0.149	bioplex_WMM WMM_only
DDR1	FADD	0.009	0.091	bioplex_WMM WMM_only
DDR1	CASP8	0.009	0.091	bioplex_WMM WMM_only
FADD	UGCG	0.008	0.088	bioplex_WMM WMM_only
CASP8	UGCG	0.008	0.088	bioplex_WMM WMM_only
DDR1	UGCG	0.008	0.081	bioplex_WMM WMM_only
RNF149	DDR1	0.008	0.032	bioplex_WMM WMM_only
LSS	CASP8	0.007	0.005	bioplex_WMM WMM_only
LSS	FADD	0.007	0.005	bioplex_WMM WMM_only
RNF149	FADD	0.007	0.007	bioplex_WMM WMM_only
RNF149	CASP8	0.007	0.007	bioplex_WMM WMM_only
FADD	FAM118B	0.007	0.008	bioplex_WMM WMM_only
CASP8	FAM118B	0.007	0.008	bioplex_WMM WMM_only
RNF149	TNFRSF10A	0.007	0.009	bioplex (TNFRSF10A) bioplex_WMM
LSS	UGCG	0.007	0.004	bioplex_WMM WMM_only
LSS	TNFRSF10B	0.007	0.002	bioplex_WMM WMM_only
RNF149	LSS	0.007	0.005	bioplex_WMM WMM_only
FAS	UGCG	0.006	0.003	bioplex_WMM WMM_only
FAS	RNF149	0.006	0.004	bioplex_WMM WMM_only

Images

Click to enlarge

Complex HuMAP2_04304 has an average edge precision of 0.163 which is ranked 6594 out of all 6965 complexes.

Related Complexes

Genename	Complexes
DDR1	HuMAP2_00418 HuMAP2_02134 HuMAP2_04304 HuMAP2_06332
TNFRSF10B	HuMAP2_00418 HuMAP2_02013 HuMAP2_02134 HuMAP2_04236 HuMAP2_04304 HuMAP2_05774 HuMAP2_06332
IL37	HuMAP2_00418 HuMAP2_02134 HuMAP2_04304 HuMAP2_05457 HuMAP2_05774
FAS	HuMAP2_00418 HuMAP2_02013 HuMAP2_02134 HuMAP2_04236 HuMAP2_04304 HuMAP2_05774
TNFRSF10A	HuMAP2_00418 HuMAP2_02013 HuMAP2_02134 HuMAP2_04236 HuMAP2_04304 HuMAP2_05774
FADD	HuMAP2_00418 HuMAP2_02013 HuMAP2_02134 HuMAP2_04236 HuMAP2_04304 HuMAP2_05457 HuMAP2_05774
RNF149	HuMAP2_00418 HuMAP2_02134 HuMAP2_04304 HuMAP2_06332
LSS	HuMAP2_00418 HuMAP2_01884 HuMAP2_02134 HuMAP2_04304 HuMAP2_05833
CASP8	HuMAP2_00418 HuMAP2_02013 HuMAP2_02134 HuMAP2_04236 HuMAP2_04304 HuMAP2_05774 HuMAP2_06332
FAM118B	HuMAP2_00418 HuMAP2_02013 HuMAP2_04298 HuMAP2_04304
UGCG	HuMAP2_00418 HuMAP2_01958 HuMAP2_02134 HuMAP2_04236 HuMAP2_04304 HuMAP2_06332

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_04304